Detailed description page of Selected OV_ID


OV_5677 details
Primary information
OV_IDOV_5677
Virus Name Herpes simplex virus
StrainHSV-R8306
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for Gamma 34.5 gene and addition of IL-4 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC57BL/6 mice xenograft for GL-261 (1.0 ×10⁵)
In-vivo virus concentration1 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultIncrease in survival of mice up to 28 day
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMIDUS7744899