| Primary information |
|---|
| OV_ID | OV_5677 |
| Virus Name | Herpes simplex virus |
| Strain | HSV-R8306 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Deletion mutant for Gamma 34.5 gene and addition of IL-4 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C57BL/6 mice xenograft for GL-261 (1.0 ×10âµ) |
| In-vivo virus concentration | 1 ×10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Increase in survival of mice up to 28 day |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US7744899 |