Detailed description page of Selected OV_ID


OV_5545 details
Primary information
OV_IDOV_5545
Virus Name Herpes simplex virus
StrainMutant
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutatnt in TK gene and UL 24 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman malignant cell line
Cell lineU87
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFisher male mice xenograft subrenal for U86 (3 ×10⁶)
In-vivo virus concentration5 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultTumor size was significantly smaller in treated mice compared to control
Mode of deliveryIntravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMIDUS6770274