Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_2878Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineHOSConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result5% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2879Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-5Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result78% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2880Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-5Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2881Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-5Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2882Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-5Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2883Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-32Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2884Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-32Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result42% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2885Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-32Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result38% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2886Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineIMR-32Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2887Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSK-N-ASConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2888Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSK-N-ASConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2889Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSK-N-ASConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2890Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSK-N-ASConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2891Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSKNBE2Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2892Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSKNBE2Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2893Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSKNBE2Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result38% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2894Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineSKNBE2Concentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2895Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell lineCell lineBT16GFPFlucConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismCD-1 mice xenograft for cell line (1.0E+5) In-vivo virus concentration5.0E+7 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volumeMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2896Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineNeuroblastoma cell line SKNASmCherryFlucCell lineSK-N-ASmCherryFlucConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismCB17 SCID mice xenograft for cell line (5.0E+6)In-vivo virus concentration5.0E+7 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volumeMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_3045Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3046Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3047Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3048Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3049Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3050Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3051Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3052Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3053Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3054Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3055Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3056Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3057Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3058Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3059Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3060Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3061Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3062Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3063Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result80% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3064Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3065Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3066Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3067Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3068Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3069Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3070Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3071Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3072Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3073Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result5% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3074Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3075Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3076Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3077Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3078Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3079Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3080Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3081Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3082Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3083Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result5% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3084Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3085Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3086Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman glioblastoma cell lineCell lineU-87 MGConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result5% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3087Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3088Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3089Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3090Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result45% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3091Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3092Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3093Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result85% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3094Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result45% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3095Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman eosophageal cancer cell lineCell lineOE19Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result5% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3096Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3097Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result2% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3098Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3099Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3100Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result2% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3101Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3102Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3103Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3104Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3105Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 500mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3106Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineLoVoConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to 500mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3107Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman colon cancer cell lineCell lineOE19Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 1000 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3108Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineECACCOrigin of cell lineHuman colon cancer cell lineCell lineOE19Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to 250 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3109Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 100 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3110Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bladder cancer cell lineCell lineSW780Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 100 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3111Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 1500 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3112Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHepG2Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 1000 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3113Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 3500 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3114Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman stomach cancer cell lineCell lineHs746TConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 1000 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3115Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 100 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3116Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineCantren Antoine- lacassagne, FranceOrigin of cell lineHuman head and neck squamous cell carcinoma cell lineCell lineCAL33Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 100 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3117Virus nameVaccinia virusVirus strainVaccinia virus deltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 500 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3118Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneNoVirus in combination with drug/radiationVirus strain in combination with 5-FC (200mg/kg)Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colon cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBD62 mice xenograft for Lovo cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreases to below 100 mm after 50 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3189Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration0.0001 MOIIn-vitro result75% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3190Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration0.001 MOIIn-vitro result50% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3191Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration0.01 MOIIn-vitro result45% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3192Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration0.1 MOIIn-vitro result45% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3193Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration1 MOIIn-vitro result40% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3194Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman edwig sarcoma cell lineCell lineRD-ESConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration10 MOIIn-vitro result45% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891
IDOV_3219Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman bone osteosarcoma cell lineCell line143-BConcentration of cell line90% confluenceIn-vitro toxicityNAAssayCrystal violet staining and absorbance at 595 nmIn-vitro virus concentration0.0001 MOIIn-vitro result75% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectGenration of memory immune response by incresing production of cytokinesClinical trialNAPMID28568891