| Primary information |
|---|
| OV_ID | OV_2895 |
| Virus Name | Vaccinia virus |
| Strain | vvDD |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Deletion of TK gene and vaccinia growth factor |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Laboratory grown own culture |
| Origin of cell line | Neuroblastoma cell line |
| Cell line | BT16GFPFluc |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | CD-1 mice xenograft for cell line (1 × 10ⵠ)
|
| In-vivo virus concentration | 5 × 10ⷠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Significant reduction in tumor volume |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 23816608 |