Detailed description page of Selected OV_ID


OV_3116 details
Primary information
OV_IDOV_3116
Virus Name Vaccinia virus
StrainDeltaJ2R-I4L/FCU1 VACV (TG6002)
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDeletion of J2R and I4L gene and insertion of gene FCU1
Virus aloneNo
Virus in combination iwth drug/radiationVirus strain in combination with 5-FC (200mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineCantren Antoine- lacassagne, France
Origin of cell lineHuman head and neck squamous cell carcinoma cell line
Cell lineCAL33
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBD62 mice xenograft for Lovo cell line
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultTumor volume decreases to below 100 mm after 50 days
Mode of deliveryIntravenous
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID31011628