| Primary information |
|---|
| OV_ID | OV_3115 |
| Virus Name | Vaccinia virus |
| Strain | DeltaJ2R/FCU1 VACV |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Deletion of J2R gene and insertion of gene FCU1 |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus strain in combination with 5-FC (200mg/kg) |
| Immune gene induction in virus genome | No |
| Source of cell line | Cantren Antoine- lacassagne, France |
| Origin of cell line | Human head and neck squamous cell carcinoma cell line |
| Cell line | CAL33 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BD62 mice xenograft for Lovo cell line |
| In-vivo virus concentration | 1 × 10ⷠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume decreases to below 100 mm after 50 days |
| Mode of delivery | Intravenous |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 31011628 |