The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_619	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_620	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_621	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	52% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_622	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_623	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_624	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_625	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_626	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_627	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_628	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	38% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_629	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_630	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_631	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_632	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_633	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	30% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_634	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_635	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_636	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	58% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_637	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_638	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_639	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_640	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	107% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_641	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_642	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_643	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	61% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_644	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_645	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	93% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_646	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	87% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_647	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	58% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_648	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	59% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_649	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	111% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_650	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	102% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_651	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_652	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	75% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_653	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_654	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	106% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_655	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	95% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_656	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	89% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_657	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	39% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_658	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_659	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_660	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	96% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_661	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_662	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_663	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_664	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_665	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	94% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_666	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_667	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	91% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_668	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_669	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_670	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	78% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_671	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_672	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	20% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_673	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	12% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_674	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_675	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_676	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	17% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_677	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_678	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_679	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to mock-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_680	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_681	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_682	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_683	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_684	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_685	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_686	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_687	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_688	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	30% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_689	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_690	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	126% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_691	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_692	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	72% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_693	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	61% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_694	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_695	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_696	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_697	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	99% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_698	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_699	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	108% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_700	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_701	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_702	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	85% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_703	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_704	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_705	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_706	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_707	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_708	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	19% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_709	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft female CD1 nude mice subcutaneously injected with 3.0E+6 A375 cells	1.0E+6 pfu/ml	NA	%volume change is 400 as compared to control 700 after 40 days	Intratumoral	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 3	NA	NA	27384486
OV_710	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 2 Gy for 3 cycles	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft female CD1 nude mice subcutaneously injected with 3.0E+6 A375 cells	1.0E+6 pfu/ml	NA	%volume change is 100 as compared to control 700 after 40 days	Intratumoral	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 3	NA	NA	27384486
OV_711	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	77% survived till 30 days (Reduction in tumor volume to 0.15 cubic centimeter compared to control 0.9 cubic centimeter after 15 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_712	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	80% survived till 40 days (Reduction in tumor volume to 0.3 cubic centimeter compared to control 1.0 cubic centimeter after 20 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241
OV_713	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells (vaccinated with cell-based Reovirus vaccine 8–12 weeks prior to day 0)	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	100% survived till 150 days (Reduction in tumor volume to 0.0 cubic centimeter compared to control 1.4 cubic centimeter after 16 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_714	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells (vaccinated with cell-based Reovirus vaccine 8–12 weeks prior to day 0)	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	100% survived till 200 days (Reduction in tumor volume to 0.0 cubic centimeter compared to control 1.3 cubic centimeter after 11 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241
OV_715	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells (prior single dose of cell-based reovirus vaccine for the treatment of established tumours)	2.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	77% survived till 44 days (Reduction in tumor volume to 0.1 cubic centimeter compared to control 1.2 cubic centimeter after 16 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_716	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells (prior single dose of cell-based reovirus vaccine for the treatment of established tumours)	3.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	60% survived till 52 days (Reduction in tumor volume to 0.14 cubic centimeter compared to control 21 cubic centimeter after 15 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241
OV_1121	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	ATCC	Cervical cancer cell line	HeLaS3	1.0E+5 cells per well	NA	Fluoroscent mesure at 450nm	0.01MOI	50% cell viablity	No	No	NA	No response		Apoptosis induction in cancer cell lines	NA	NA	15958641
OV_1122	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	ATCC	Cervical cancer cell line	HeLaS3	1.0E+5 cells per well	NA	Fluoroscent mesure at 450nm	0.1MOI	30% cell viability	No	No	NA	No response		Apoptosis induction in cancer cell lines	NA	NA	15958641