Detailed description page of Selected OV_ID


OV_710 details
Primary information
OV_IDOV_710
Virus Name Reovirus
StrainRT3D (Reolysin)
Virus typeRNA
Virus familyReoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with radiation, 2 Gy for 3 cycles
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismXenograft female CD1 nude mice subcutaneously injected with 3 × 10⁶ A375 cells
In-vivo virus concentration1 × 10⁶ pfu/ml
In-vivo toxicityNA
In-vivo result%volume change is 100 as compared to control 700 after 40 days
Mode of deliveryIntratumoral
Pathway inductionDown-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 3
Immunogenic effectNA
Clinical trialNA
PMID27384486