Detailed description page of Selected OV_ID


OV_711 details
Primary information
OV_IDOV_711
Virus Name Reovirus
StrainRT3D (Reolysin)
Virus typeRNA
Virus familyReoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC57Bl/6j mice subcutaneously injected with 5 × 10⁵ B16F10 cells
In-vivo virus concentration1 × 10⁷ PFU to 1 × 10⁹ PFU for three weeks
In-vivo toxicityNA
In-vivo result77% survived till 30 days (Reduction in tumor volume to 0.15 cubic centimeter compared to control 0.9 cubic centimeter after 15 days)
Mode of deliveryintravenously
Pathway inductionNA
Immunogenic effectUp-regulation of IL-12, IL-5, IL-10, TNF-alpha
Clinical trialNA
PMID27412241