Browse By Model Organism Result Page of OvirusTdb
The total number of records retrieved from this search are 61. Click on ID to see further detail.
IDOV_5785 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration1.0E+7 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 176.9 mm compared to control 278.1 after 53 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5786 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration1.0E+7 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 598.8mm compared to control 755 after 63 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5787 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration1.0E+7 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 668.4 mm compared to control 1169.9 after 69 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5788 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration1.0E+7 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 896.6 mm compared to control 2512.7 after 77 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5789 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 298.8 after 41 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5790 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 1448.3 after 55 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5791 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 2512.4 after 64 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5792 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 34.07 after 71 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5793 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 415.1 after 41 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5794 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 1403.1 after 55 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5795 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 1163.7 after 64 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5796 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 993 after 71 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5797 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 757.5 after 79 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5798 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 667 after 87 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5799 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 547 after 93 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5800 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 549 after 99 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5801 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 511 after 106 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5802 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 465.3 after 113 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5803 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration2.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes 441.3 after 119 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5804 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 268.4 after 55 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5805 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 623.7 after 62 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5806 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 1232.5 after 70 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5807 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 1277.05 after 75 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5808 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 1189.55 mm after 81 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5809 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 744.4mm after 89 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5810 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 402.1 after 55 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5811 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 1128.15 after 62 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5812 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 1485.05 after 70 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5813 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume becomes to 1599.35 after 75 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5814 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 1411.4mm after 81 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5815 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 1040mm after 89 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5816 | Virus nameVaccinia virus | Virus strainGLV-1h68 | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively | Virus aloneNo | Virus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6) | In-vivo virus concentration5.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 906.75 mm after 96 days | Mode of deliveryIntravenously | Pathway inducedInduction of apoptosis | Immunogenic effectNA | Clinical trialNA | PMIDUS8052968 |
IDOV_5856 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for HT1080 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 11 mouse out of 12 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5857 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for PA-1 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 9 mouse out of 9 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5858 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for KB (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 7 mouse out of 12 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5859 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for SKMEL5 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 5 mouse out of 8 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5860 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 1 mouse out of 8 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5861 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for U87MG (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor in 1 mouse out of 9 | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5862 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration1.5E+9 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 2 out of 8 (tumor dimension 8 - 9.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5863 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration9.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 7 out of 8 (tumor dimension 8 - 9.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5864 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 3 out of 8 (tumor dimension 8 - 9.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5865 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 3 out of 3 (tumor dimension 10 - 11 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5866 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 3 out of 3 (tumor dimension 10 - 11 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5867 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in 3 out of 3 (tumor dimension 10 - 11 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5868 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration1.5E+9 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 2 out of total 6 (tumor volume <300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5869 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration9.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 3 out of total 4 (tumor volume <300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5870 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 2 out of total 6 (tumor volume <300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5871 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration1.5E+9 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 3 out of total 5 (tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5872 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration9.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 7 out of total 7 (tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5873 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+10 pfu | In-vivo toxicityNA | In-vivo resultComplete regression in tumor volume in 4 out of total 5 (tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5874 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration1.5E+9 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor 7 out of 7 (tumor dimension 10 - 11.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5875 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor 6 out of 7 (tumor dimension 10 - 11.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5876 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+7 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor 5 out of 7 (tumor dimension 10 - 11.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5877 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+6 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor 5 out of 7 (tumor dimension 10 - 11.5 mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5878 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration1.5E+9 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor volume 7 out of 7 (Tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5879 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+8 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor volume 6 out of 7 (Tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5880 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+7 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor volume 4 out of 6 (Tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5881 | Virus nameNewcastle disease virus | Virus strainNDV-PPMK107 | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeYes | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for A375 (10 million) | In-vivo virus concentration3.0E+6 pfu | In-vivo toxicityNA | In-vivo resultComplete reduction in tumor volume 4 out of 6 (Tumor volume >300mm) | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8105578 |
IDOV_5882 | Virus nameHerpes simplex virus | Virus strainMutant | Virus genome typeDNA | Virus familyHerpesviridae | Virus genome modificationDeletion mutant for Gamma 34.5 gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeVirus expressing vasculostatin peptide | Source of cell lineATCC | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic mice xenograft for U87DeltaEGFR | In-vivo virus concentration1.0E+5 pfu | In-vivo toxicityNA | In-vivo resultSurvival time increased | Mode of deliveryIntratumoral | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMIDUS8450106 |
IDOV_5889 | Virus nameRespiratory synctial virus | Virus strainMutant | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic nude mice xenograft for PC-3 (3.0E+6), below ear | In-vivo virus concentration1.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 200mm after 38 days compared to control 1200mm | Mode of deliveryIntratumoral | Pathway inducedInduction of apoptosis as measured by TUNEL assay | Immunogenic effectNA | Clinical trialNA | PMIDUS9241998 |
IDOV_5890 | Virus nameRespiratory synctial virus | Virus strainMutant | Virus genome typeRNA | Virus familyParamyxoviridae | Virus genome modificationNone | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismAthymic nude mice xenograft for PC-3 (3.0E+6), below ear | In-vivo virus concentration1.0E+6 pfu | In-vivo toxicityNA | In-vivo resultTumor volume reduced to 300mm after 35 days compared to control 900mm | Mode of deliveryIntratumoral | Pathway inducedInduction of apoptosis as measured by TUNEL assay | Immunogenic effectNA | Clinical trialNA | PMIDUS9241998 |