| Primary information |
|---|
| OV_ID | OV_5890 |
| Virus Name | Respiratory synctial virus |
| Strain | Mutant |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Athymic nude mice xenograft for PC-3 (3 ×10â¶), dorsal flank |
| In-vivo virus concentration | 1 ×10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume reduced to 300mm after 35 days compared to control 900mm |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis as measured by TUNEL assay |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US9241998 |