Detailed description page of Selected OV_ID


OV_5889 details
Primary information
OV_IDOV_5889
Virus Name Respiratory synctial virus
StrainMutant
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice xenograft for PC-3 (3 ×10⁶), below ear
In-vivo virus concentration1 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultTumor volume reduced to 200mm after 38 days compared to control 1200mm
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMIDUS9241998