IonNTxPred

IonNTxPred – Rapid Screening is a fast, rule-based module designed for instant identification of ion-channel modulators using cysteine composition (AAC_C).

Instead of deep learning, this module applies experimentally corrected probabilities derived from large datasets (Table-4) to estimate the likelihood that a peptide acts as:

🧩 Na⁺ channel modulator
🧩 K⁺ channel modulator
🧩 Ca²⁺ channel modulator
🧩 Other ion-channel modulator

🧬 How it works:

The percentage of cysteine (AAC_C) is calculated for each peptide
AAC_C> is mapped to statistically corrected probabilities
Both Modulator and Non-Modulator probabilities are reported

Rapid Screening Probabilities Based on Cystine Composition

Corrected probabilities (%) for identifying ion channel–modulating peptides using cystine (AAC_C) content.

Composition of Cystine (%)	Na⁺ Channel		K⁺ Channel		Ca²⁺ Channel		Other Channels
Composition of Cystine (%)	Modulator (%)	Non-Modulator (%)	Modulator (%)	Non-Modulator (%)	Modulator (%)	Non-Modulator (%)	Modulator (%)	Non-Modulator (%)
1	5.8	94.2	3.7	96.3	7.8	92.2	4.0	96.0
2	2.2	97.8	0.0	100.0	2.6	97.4	1.9	98.1
3	0.0	100.0	0.0	100.0	3.6	96.4	2.7	97.3
4	1.8	98.2	24.1	75.9	31.9	68.1	4.4	95.6
5	11.1	88.9	12.8	87.2	9.8	90.2	19.2	80.8
6	37.5	62.5	38.4	61.6	40.3	59.7	41.7	58.3
7	44.2	55.8	64.6	35.4	69.2	30.8	72.2	27.8
8	70.3	29.7	74.5	25.5	68.3	31.7	70.9	29.1
9	77.5	22.5	82.1	17.9	84.6	15.4	75.5	24.5
10	89.8	10.2	83.8	16.2	78.0	22.0	82.8	17.2
11	88.1	11.9	82.2	17.8	85.5	14.5	88.9	11.1
12	88.8	11.2	88.9	11.1	84.8	15.2	91.6	8.4
13	96.4	3.6	92.5	7.5	91.0	9.0	94.8	5.2
14	85.8	14.2	90.3	9.7	86.1	13.9	94.1	5.9
15	93.7	6.3	95.3	4.7	91.8	8.2	93.7	6.3
16	91.3	8.7	96.2	3.8	95.7	4.3	93.4	6.6
17	95.1	4.9	97.9	2.1	98.3	1.7	85.9	14.1
18 or Greater	95.8	4.1	95.9	4.0	96.0	3.9	94.8	5.1

⚡ No model loading, no threshold tuning — results are generated instantly.

📘 Recommended for:

Large-scale screening
Pre-filtering before ML-based prediction
Quick biological interpretation

IonNTxPred - A webserver to predict ion channel impairing proteins

⚡ Rapid Screening of Ion Channel-Impairing Proteins

Rapid Screening Probabilities Based on Cystine Composition