Browse result page of ImmunoSPdb

The total number entries retrieved from this search are 67
IDNameSequenceLengthChiralityN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicNatureSourceTargetMechanism of ActionIn vivo/ In vitroCell LineIC-50In vivo ModelAssay TypeLethal DoseCombination TherapyPubmed IDYear of Publication
1302Copolymer 1-related heteropolymerAYKAEAAAAAAAAAA15LNoneNoneNoneLinearSyntheticNA (Random copolymer)T-cellsInhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ)In vivoNANABALB/c mice, Lewis ratsSkin Grafts Transplantation, Thyroid graft TransplantationNACopolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymerUS 20060276390 A12006
1303Copolymer 1-related heteropolymerAKYAEAAAAAAAAAA15LNoneNoneNoneLinearSyntheticNA (Random copolymer)T-cellsInhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ)In vivoNANABALB/c mice, Lewis ratsSkin Grafts Transplantation, Thyroid graft TransplantationNACopolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymerUS 20060276390 A12006
1464SEQ ID4QKRAAYDQYGHAAFE15LNoneNoneNoneLinearSyntheticdnaJP1NAinducing T-cell responseIn vitroPeripheral blood lymphocytesNANoneNANANAUS 6946132 B22005
1465SEQ ID5DERAAYDQYGHAAFE15LNoneNoneNoneLinearSyntheticdnaJNAinducing T-cell responseIn vitroPeripheral blood lymphocytesNANoneNANANAUS 6946132 B22005
1466SEQ ID6VLTDSQKRAAYDQYG15LNoneNoneNoneLinearSyntheticdnaJP2NAinducing T-cell responseIn vitroPeripheral blood lymphocytesNANoneNANANAUS 6946132 B22005
1467SEQ ID7QKRAAVDTYCRHNYG15LNoneNoneNoneLinearProtein Derivedhuman S1 HLA peptideNAinducing T-cell responseIn vitroPeripheral blood lymphocytesNANoneNANANAUS 6946132 B22005
1521RTL401GGGGSLVPRGSGGGG15LNoneNoneNoneLinearProtein DerivedI-As/proteolipid proteinT-cellscytokine switch in targeted T cells to produce anti-inflammatory cytokines,reduction of infiltrating mononuclear cells into CNSIn vivoNANASJL miceImmunoblotting, Cytokine determination by cytometric bead array, ELISANAautoimmune encepha- lomyelitis 161481602005
1524119RVAALEEANTELEVKI15LNoneNoneNoneLinearProtein Derivedkeratin 17Psoriatic T-cells and keratinocyteInhibition of T-cell proliferation , secretion of interferon gamma and interleukin 2 and up-regulation of interleukins 4 and 10In vitroNANANACytokine secretion assay, T-cell proliferation assayNANA167134532006
1525355LENRYCVQASQIQGLI15LNoneNoneNoneLinearProtein Derivedkeratin 18Psoriatic T-cells and keratinocyteInhibition of T-cell proliferation , secretion of interferon gamma and interleukin 2 and up-regulation of interleukins 4 and 11In vitroNANANACytokine secretion assay, T-cell proliferation assayNANA167134532006
1536MSP1 peptideISVLKSRLLKRKKYI15LNoneNoneNoneLinearProtein Derivedmerozoite surface protein 1 (MSP1)IL-10Not AvailableBothCTLL-2 cells, B5 CD4 T cell hybridomaNABALB/c miceNANANA230068472012
1539HSP60 peptideCAELKKQSKPVT12LNoneNoneNoneLinearProtein DerivedHeat shock protein 60 (HSP60)IL-10, TGF-βInduced T-cell proliferation and expansion of regulatory T cellsBothSplenocytes, Dendritic CellsNAC57BL6/JCytometric bead assayNANA234003022013
1540Peptide ACTLDLNTPVDKTSN14LNoneNoneNoneLinearProtein DerivedComplement receptor 5aTNF-αSlightly stimulates T cellsBothSplenocytes, Dendritic CellsNAC57BL6/JCytometric bead assayNANA234003022013
1542Cry j 1 peptide (61-75)GATRDRPLWIIFSGN15LNoneNoneNoneLinearProtein DerivedCry j 1 proteinIL-10Production of CD4+CD25+ Treg cellsIn vitroHeparinized venous bloodNANACFSE-based proliferation assay, ELISPOT assayNANA215972992011
1551altered peptide ligand (APL),HSLGKQLGHPDKF13LNoneNoneNoneLinearSyntheticSubsitution of trytophan to glutamine in myelin proteolipid proteinCross reacts with native peptideInduces T- cells that produces Th2 (IL-4 and IL-10) and Th0 (IFN-γ and IL-10)BothT cell linesNAFemale (4 to 6week-old) SJL miceIn vitro cytokine assaysNANA75841311995
1552P1182-1194WEGVGVVPDVAVP13LNoneNoneNoneLinearProtein Derivedinterphotoreceptor retinoid-binding protein (IRBP)-derived peptideNAInduces T cells production with IL-4 and IL-10BothPeptide specific T cell linesNABALB/c nude miceLymphocyte proliferation assayNANA96034631998
1553262LysVIVKLIPSTSSAV13LNoneNoneNoneLinearSyntheticAnalog of Peptide p259-271 of the human acetylcholine receptor a-subunitNAInhibited complete secretion of IL-2 and IL-4 and inhibit effeicintly IL-10 and TNF-αBothT cell lineNAFemale mice of the inbred strain BALBrcCytokine detectionNANA96270001998
1554262SerVIVSLIPSTSSAV13LNoneNoneNoneLinearSyntheticAnalog of Peptide p259-271 of the human acetylcholine receptor a-subunitNAInhibited complete secretion of IL-2 and IL-4 and inhibit effeicintly IL-10 and TNF-αBothT cell lineNAFemale mice of the inbred strain BALBrcCytokine detectionNANA96270001998