1302 | Copolymer 1-related heteropolymer | AYKAEAAAAAAAAAA | 15 | L | None | None | None | Linear | Synthetic | NA (Random copolymer) | T-cells | Inhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ) | In vivo | NA | NA | BALB/c mice, Lewis rats | Skin Grafts Transplantation, Thyroid graft Transplantation | NA | Copolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymer | US 20060276390 A1 | 2006 |
1303 | Copolymer 1-related heteropolymer | AKYAEAAAAAAAAAA | 15 | L | None | None | None | Linear | Synthetic | NA (Random copolymer) | T-cells | Inhibits T cell proliferation in response to graft cells, preventing the secretion of cytokines like interleukin 2 (IL-2) and interferon γ (IFN-γ) | In vivo | NA | NA | BALB/c mice, Lewis rats | Skin Grafts Transplantation, Thyroid graft Transplantation | NA | Copolymer 1-related heteropolymers in combination with other immunosuppressive drugs induce a synergistic effect, This is used as copolymer or related hateropolymer | US 20060276390 A1 | 2006 |
1464 | SEQ ID4 | QKRAAYDQYGHAAFE | 15 | L | None | None | None | Linear | Synthetic | dnaJP1 | NA | inducing T-cell response | In vitro | Peripheral blood lymphocytes | NA | None | NA | NA | NA | US 6946132 B2 | 2005 |
1465 | SEQ ID5 | DERAAYDQYGHAAFE | 15 | L | None | None | None | Linear | Synthetic | dnaJ | NA | inducing T-cell response | In vitro | Peripheral blood lymphocytes | NA | None | NA | NA | NA | US 6946132 B2 | 2005 |
1466 | SEQ ID6 | VLTDSQKRAAYDQYG | 15 | L | None | None | None | Linear | Synthetic | dnaJP2 | NA | inducing T-cell response | In vitro | Peripheral blood lymphocytes | NA | None | NA | NA | NA | US 6946132 B2 | 2005 |
1467 | SEQ ID7 | QKRAAVDTYCRHNYG | 15 | L | None | None | None | Linear | Protein Derived | human S1 HLA peptide | NA | inducing T-cell response | In vitro | Peripheral blood lymphocytes | NA | None | NA | NA | NA | US 6946132 B2 | 2005 |
1521 | RTL401 | GGGGSLVPRGSGGGG | 15 | L | None | None | None | Linear | Protein Derived | I-As/proteolipid protein | T-cells | cytokine switch in targeted T cells to produce anti-inflammatory cytokines,reduction of infiltrating mononuclear cells into CNS | In vivo | NA | NA | SJL mice | Immunoblotting, Cytokine determination by cytometric bead array, ELISA | NA | autoimmune encepha- lomyelitis | 16148160 | 2005 |
1524 | 119R | VAALEEANTELEVKI | 15 | L | None | None | None | Linear | Protein Derived | keratin 17 | Psoriatic T-cells and keratinocyte | Inhibition of T-cell proliferation , secretion of interferon gamma and interleukin 2 and up-regulation of interleukins 4 and 10 | In vitro | NA | NA | NA | Cytokine secretion assay, T-cell proliferation assay | NA | NA | 16713453 | 2006 |
1525 | 355L | ENRYCVQASQIQGLI | 15 | L | None | None | None | Linear | Protein Derived | keratin 18 | Psoriatic T-cells and keratinocyte | Inhibition of T-cell proliferation , secretion of interferon gamma and interleukin 2 and up-regulation of interleukins 4 and 11 | In vitro | NA | NA | NA | Cytokine secretion assay, T-cell proliferation assay | NA | NA | 16713453 | 2006 |
1536 | MSP1 peptide | ISVLKSRLLKRKKYI | 15 | L | None | None | None | Linear | Protein Derived | merozoite surface protein 1 (MSP1) | IL-10 | Not Available | Both | CTLL-2 cells, B5 CD4 T cell hybridoma | NA | BALB/c mice | NA | NA | NA | 23006847 | 2012 |
1539 | HSP60 peptide | CAELKKQSKPVT | 12 | L | None | None | None | Linear | Protein Derived | Heat shock protein 60 (HSP60) | IL-10, TGF-β | Induced T-cell proliferation and expansion of regulatory T cells | Both | Splenocytes, Dendritic Cells | NA | C57BL6/J | Cytometric bead assay | NA | NA | 23400302 | 2013 |
1540 | Peptide A | CTLDLNTPVDKTSN | 14 | L | None | None | None | Linear | Protein Derived | Complement receptor 5a | TNF-α | Slightly stimulates T cells | Both | Splenocytes, Dendritic Cells | NA | C57BL6/J | Cytometric bead assay | NA | NA | 23400302 | 2013 |
1542 | Cry j 1 peptide (61-75) | GATRDRPLWIIFSGN | 15 | L | None | None | None | Linear | Protein Derived | Cry j 1 protein | IL-10 | Production of CD4+CD25+ Treg cells | In vitro | Heparinized venous blood | NA | NA | CFSE-based proliferation assay, ELISPOT assay | NA | NA | 21597299 | 2011 |
1551 | altered peptide ligand (APL), | HSLGKQLGHPDKF | 13 | L | None | None | None | Linear | Synthetic | Subsitution of trytophan to glutamine in myelin proteolipid protein | Cross reacts with native peptide | Induces T- cells that produces Th2 (IL-4 and IL-10) and Th0 (IFN-γ and IL-10) | Both | T cell lines | NA | Female (4 to 6week-old) SJL mice | In vitro cytokine assays | NA | NA | 7584131 | 1995 |
1552 | P1182-1194 | WEGVGVVPDVAVP | 13 | L | None | None | None | Linear | Protein Derived | interphotoreceptor retinoid-binding protein (IRBP)-derived peptide | NA | Induces T cells production with IL-4 and IL-10 | Both | Peptide specific T cell lines | NA | BALB/c nude mice | Lymphocyte proliferation assay | NA | NA | 9603463 | 1998 |
1553 | 262Lys | VIVKLIPSTSSAV | 13 | L | None | None | None | Linear | Synthetic | Analog of Peptide p259-271 of the human acetylcholine receptor a-subunit | NA | Inhibited complete secretion of IL-2 and IL-4 and inhibit effeicintly IL-10 and TNF-α | Both | T cell line | NA | Female mice of the inbred strain BALBrc | Cytokine detection | NA | NA | 9627000 | 1998 |
1554 | 262Ser | VIVSLIPSTSSAV | 13 | L | None | None | None | Linear | Synthetic | Analog of Peptide p259-271 of the human acetylcholine receptor a-subunit | NA | Inhibited complete secretion of IL-2 and IL-4 and inhibit effeicintly IL-10 and TNF-α | Both | T cell line | NA | Female mice of the inbred strain BALBrc | Cytokine detection | NA | NA | 9627000 | 1998 |