| Primary information |
|---|
| ID | 1551 |
| Peptide Name | altered peptide ligand (APL), |
| Sequence | HSLGKQLGHPDKF |
| Length | 13 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Synthetic |
| Source of Origin | Subsitution of trytophan to glutamine in myelin proteolipid protein |
| Target | Cross reacts with native peptide |
| Mechanism of Action | Induces T- cells that produces Th2 (IL-4 and IL-10) and Th0 (IFN-γ and IL-10) |
| In vitro/In vivo | Both |
| Cell Line | T cell lines |
| Inhibition Concentartion | NA |
| In vivo Model | Female (4 to 6week-old) SJL mice |
| Assay | In vitro cytokine assays |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 7584131 |
| Year of Publication | 1995 |
| 3-D Structure |  View in Jmol or Download Structure |
