A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20993 |
| Swiss-prot Accession number | P21463 (Sequence in FASTA format) |
| Description | Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 8 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). |
| Protein Length | 764 Amino acids |
| Molecular weight | 86475 |
| Domain Name | 7tm_1 LRR_1 |
| References | 1 PubMed abstract 1696008 2 PubMed abstract 1332945 |
| Hormone | P04652 Detail in HMRbase Q925Q4 Detail in HMRbase |
| Gene ID | 25360 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |