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HMRbase accession number | 11579 |
Swiss-prot Accession number | P08424 (Sequence in FASTA format) |
Description | Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor |
Source organism | Rattus norvegicus (Rat) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
Subcellular location | Secreted (By similarity). Membrane (By similarity). Note=Associated to membranes via binding to ATP6AP2 (By similarity) |
Developmental Stage | N/A |
Similarity | Belongs to the peptidase A1 family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
Protein Length | 402 Amino acids |
Molecular weight | 44276 |
References | 1 PubMed abstract 3287330 2 PubMed abstract 3039496 3 PubMed abstract 3047403 4 PubMed abstract 8490598 5 PubMed abstract 15489334 |
Domain Name | A1_Propeptide Asp |
Hormone Name | Renin |
Mature Hormone Sequence | |
Position of mature hormone in Pre-Hormone protein | |
Receptor | Q6AXS4 Detail in HMRbase |
Gene ID | 24715 |
PDB ID | N/A |
Drugpedia | wiki |
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