A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11440 |
| Swiss-prot Accession number | P33711 (Sequence in FASTA format) |
| Description | Somatotropin precursor (Growth hormone). |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the somatotropin/prolactin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues |
| Protein Length | 216 Amino acids |
| Molecular weight | 24468 |
| References | 1 PubMed abstract 8206387 2 van Leeuwen I.S., Teske E., van Garderen E., Rutteman G.R., Mol J.A.; "Extrapituitary growth hormone expression in the dog is initiated atthe normal pituitary transcription start site in the mammary gland andat multiple upstream sites in lymphoid cells."; Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 10411306 |
| Domain Name | Hormone_1 |
| Hormone Name | Somatotropin |
| Mature Hormone Sequence | FPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF |
| Position of mature hormone in Pre-Hormone protein | 190 Residues from position (27-216) |
| Receptor | Q9TU69
Detail in HMRbase |
| Gene ID | 403795 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |