| HMRbase accession number | 21200 |
| Swiss-prot Accession number | Q9TU69 (Sequence in FASTA format) |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Cell membrane; single-pass type I membrane protein (By similarity). Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Tissue Specificity | Expressed in normal and tumorous mammary tissues, being localized in epithelial and myoepithelial/spindle cell components and in the activated fibroblasts of desmoplastic tumor stroma. Isoform 1, isoform 2 and isoform 3 are found in both normal and tumorous mammary tissues, isoform 1 being the predomiant isoform. Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in the CMT-U335 cell line. |
| Post translational modification | On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling (By similarity). |
| Protein Length | 638 Amino acids |
| Molecular weight | 71041 |
| Domain Name | N/A |
| References | 1 PubMed abstract 10579357
2 PubMed abstract 8894053
|
| Hormone | P33711 Detail in HMRbase
|
| Gene ID | 403721 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors