A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11319 |
| Swiss-prot Accession number | P01241 (Sequence in FASTA format) |
| Description | Somatotropin precursor (Growth hormone) (GH) (GH-N) (Pituitary growthhormone) (Growth hormone 1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the somatotropin/prolactin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues |
| Protein Length | 217 Amino acids |
| Molecular weight | 24847 |
| References | 1 PubMed abstract 386281 2 PubMed abstract 377496 3 PubMed abstract 6269091 4 PubMed abstract 7169009 5 PubMed abstract 2744760 6 Gu J., Huang Q.-H., Li N., Xu S.-H., Han Z.-G., Fu G., Chen Z.; "A novel gene expressed in human pituitary."; Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 10931946 8 PubMed abstract 15489334 9 PubMed abstract 3912261 10 PubMed abstract 5810834 11 PubMed abstract 5144027 12 PubMed abstract 4675454 13 PubMed abstract 5279046 14 PubMed abstract 5279528 15 Niall H.D.; "The chemistry of the human lactogenic hormones."; (In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin,pp.13-20, Alpha Omega Alpha Press, Cardiff (1972). 16 PubMed abstract 7462247 17 PubMed abstract 7356479 18 PubMed abstract 7028740 19 PubMed abstract 14997482 20 PubMed abstract 10393484 21 PubMed abstract 16807684 22 PubMed abstract 3447173 23 PubMed abstract 1549776 24 PubMed abstract 7984244 25 Chantalat L., Chirgadze N.Y., Jones N., Korber F., Navaza J.,Pavlovsk A.G., Wlodawer A.; "The crystal-structure of wild-type growth-hormone at 2.5-Aresolution."; Protein Pept. Lett. 2:333-340(1995). 26 PubMed abstract 8943276 27 PubMed abstract 8552145 28 Takahashi Y., Kaji H., Okimura Y., Goji K., Abe H., Chihara K.; N. Engl. J. Med. 334:1207-1207(1996). 29 PubMed abstract 9276733 30 PubMed abstract 10391209 31 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 32 PubMed abstract 11502836 33 PubMed abstract 12655557 |
| Domain Name | Hormone_1 |
| Hormone Name | Growth hormone (Somatotropin) (GH) |
| Mature Hormone Sequence | FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
| Position of mature hormone in Pre-Hormone protein | 191 Residues from position (27-217) |
| Receptor | P10912
Detail in HMRbase |
| Gene ID | 2688 |
| PDB ID | 1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR |
| Drugpedia | wiki |
| Comments |