A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20980 |
| Swiss-prot Accession number | P10912 (Sequence in FASTA format) |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; single-pass type I membrane protein. GHBP: Secreted protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity). Isoform 2 remains fixed to the cell membrane and is not internalized. The proteolytic processed protein, GHBP, is secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Tissue Specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. In the placenta, isoform 1 predominantly expressed in chorion and decidua, isoform 4 highly expressed in villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. |
| Post translational modification | The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity). On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
| Protein Length | 638 Amino acids |
| Molecular weight | 71500 |
| Domain Name | N/A |
| References | 1 PubMed abstract 2825030 2 PubMed abstract 2813379 3 PubMed abstract 1569971 4 PubMed abstract 8855247 5 PubMed abstract 9360546 6 PubMed abstract 9058373 7 Orlovsky I.V., Borovikova I.E., Rubtsov P.M.; "Comparing of nucleotide sequences of alternatively spliced region ofmammalian growth hormone receptor genes."; Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 8360189 9 PubMed abstract 10764769 10 PubMed abstract 2406245 11 PubMed abstract 11785980 12 PubMed abstract 2779634 13 PubMed abstract 8421103 14 PubMed abstract 8504296 15 PubMed abstract 8137822 16 PubMed abstract 7565946 17 PubMed abstract 9024232 18 PubMed abstract 9814495 19 PubMed abstract 9851797 20 PubMed abstract 10391209 21 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 22 PubMed abstract 10870033 23 PubMed abstract 14678285 24 PubMed abstract 1549776 25 PubMed abstract 8943276 |
| Hormone | P01241 Detail in HMRbase |
| Gene ID | 2690 |
| PDB ID | 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR |
| Drugpedia | wiki |
| Comments |