| HMRbase accession number | 11511 |
| Swiss-prot Accession number | Q9EPI6 (Sequence in FASTA format) |
| Description | Nasal embryonic luteinizing hormone-releasing hormone factor (Nasalembryonic LHRH factor) (Juxtasynaptic attractor of caldendrin ondendritic boutons protein) (Jacob protein). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; peripheral membrane protein (By similarity). Note=Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium (By similarity) |
| Developmental Stage | N/A |
| Similarity | N/A |
| Tissue Specificity | Expressed in the brain. Highly expressed in the sensory and motor cortex, hippocampus, thalamus and amygdala. In the olfactory bulb expressed in the granular cell layer, mitral cell layer and the glomerular layer. In the hippocampus highly expressed in the regions associated with neuronal cell types as CA1, CA2, CA3 and granule cells of the dentate gyrus |
| Post translational modification | N/A |
| Function | Influences outgrowth of olfactory axons and migration of LHRH neurons |
| Protein Length | 532 Amino acids |
| Molecular weight | 60282 |
| References | 1 Hoffmann B., Seidenbecher C.I., Kreutz M.R.; "Characterization of the novel brain-specific protein Jacob."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
2 Dieterich D.C., Landwehr M., Hoffmann B., Seidenbecher C.I.,Kreutz M., Richter K., Smalla K.H., Dresbach T., Zuschratter W.,Boeckers T.M., Gundelfinger E.D., Kreutz M.R.; "Cloning and functional characterization of jacob: - Juxtasynapticattractor of caldendrin on dendritic boutons."; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
3 PubMed abstract 15489334
4 PubMed abstract 15018815
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| Domain Name | N/A |
| Hormone Name | Nasal embryonic luteinizing hormone-releasing hormone factor |
| Mature Hormone Sequence | MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHEGSPEMQPAPHNKRRLSLVSNGRYEGSISDEAVSGKTATEGPQPRVYTISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAKLVPGPSPRAFGLEQPPLPEASGRHKKLERMYSVDGVSDDVPIRTWFPKENPFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEATACDTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL |
| Position of mature hormone in Pre-Hormone protein | 532 Residues from position (1-532) |
| Receptor | P30969
Detail in HMRbase
|
| Gene ID | 117536 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors