A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21019 |
| Swiss-prot Accession number | P30969 (Sequence in FASTA format) |
| Description | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 327 Amino acids |
| Molecular weight | 37748 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1338727 2 Kakar S.S., Grantham K., Musgrove L.C., Devor D.C., Sellers J.C.,Neill J.D.; Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 7916600 4 PubMed abstract 1339279 5 PubMed abstract 8185587 6 PubMed abstract 7764374 7 Reinhart J., Xiao S., Arora K.K., Catt K.J.; Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P07490 Detail in HMRbase Q9EPI6 Detail in HMRbase |
| Gene ID | 81668 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |