A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10338 |
| Swiss-prot Accession number | Q8WXF3 (Sequence in FASTA format) |
| Description | Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). |
| Protein Length | 142 Amino acids |
| Molecular weight | 15451 |
| References | 1 Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 12686464 3 PubMed abstract 12975309 4 PubMed abstract 12506116 5 PubMed abstract 14522968 6 PubMed abstract 14522967 |
| Domain Name | N/A |
| Hormone Name | Relaxin-3 B chain |
| Mature Hormone Sequence | RAAPYGVRLCGREFIRAVIFTCGGSRW |
| Position of mature hormone in Pre-Hormone protein | 27 Residues from position (26-52) |
| Receptor | Q9NSD7 Detail in HMRbase Q8TDU9 Detail in HMRbase Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
| Gene ID | 117579 |
| PDB ID | 2FHW |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10339 |
| Swiss-prot Accession number | Q8WXF3 (Sequence in FASTA format) |
| Description | Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). |
| Protein Length | 142 Amino acids |
| Molecular weight | 15451 |
| References | 1 Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 12686464 3 PubMed abstract 12975309 4 PubMed abstract 12506116 5 PubMed abstract 14522968 6 PubMed abstract 14522967 |
| Domain Name | N/A |
| Hormone Name | Relaxin-3 A chain |
| Mature Hormone Sequence | DVLAGLSSSCCKWGCSKSEISSLC |
| Position of mature hormone in Pre-Hormone protein | 24 Residues from position (119-142) |
| Receptor | Q9NSD7 Detail in HMRbase Q8TDU9 Detail in HMRbase Q9HBX9 Detail in HMRbase Q8WXD0 Detail in HMRbase |
| Gene ID | 117579 |
| PDB ID | 2FHW |
| Drugpedia | wiki |
| Comments |