A database of hormones and their receptors |
|
|
|
|
|
|
HMRbase accession number | 21160 |
Swiss-prot Accession number | Q8WXD0 (Sequence in FASTA format) |
Description | Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (G-protein coupledreceptor affecting testicular descent) (G-protein coupled receptor106). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cell membrane; Multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. |
Post translational modification | N/A |
Function | Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). |
Protein Length | 754 Amino acids |
Molecular weight | 86453 |
Domain Name | LRR_1 Ldl_recept_a 7tm_1 |
References | 1 PubMed abstract 11809971 2 PubMed abstract 12217959 |
Hormone | P04090 Detail in HMRbase P04808 Detail in HMRbase Q8WXF3 Detail in HMRbase |
Gene ID | 122042 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |