A database of hormones and their receptors
Receptor

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HMRbase accession number21160
Swiss-prot Accession numberQ8WXD0 (Sequence in FASTA format)
DescriptionRelaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (G-protein coupledreceptor affecting testicular descent) (G-protein coupled receptor106).
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationCell membrane; Multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats.
Tissue SpecificityExpressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.
Post translational modificationN/A
Function Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
Protein Length754 Amino acids
Molecular weight86453
Domain NameLRR_1  Ldl_recept_a  7tm_1  
References1  PubMed abstract 11809971
2  PubMed abstract 12217959
HormoneP04090   Detail in HMRbase   
P04808   Detail in HMRbase   
Q8WXF3   Detail in HMRbase   
Gene ID122042      
PDB IDN/A
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