A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21210 |
| Swiss-prot Accession number | P10275 (Sequence in FASTA format) |
| Description | RecName: Androgen receptor;Alternative Name: Dihydrotestosterone receptor;Alternative Name: Nuclear receptor subfamily 3 group C member 4; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Sumoylated on Lys-386 (major) and Lys-520. Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-534 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. |
| Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3. |
| Protein Length | 919 Amino acids |
| Molecular weight | 98989 |
| Domain Name | Androgen_recep Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3216866 2 PubMed abstract 2594783 3 PubMed abstract 2342476 4 PubMed abstract 3174628 5 PubMed abstract 2911578 6 PubMed abstract 2293020 7 PubMed abstract 15489334 8 PubMed abstract 2917688 9 PubMed abstract 3353726 10 PubMed abstract 3377788 11 PubMed abstract 2546571 12 PubMed abstract 3353727 13 PubMed abstract 1775137 14 PubMed abstract 1561105 15 PubMed abstract 9096391 16 PubMed abstract 10332029 17 PubMed abstract 10075738 18 PubMed abstract 10383460 19 PubMed abstract 10400640 20 PubMed abstract 10625666 21 PubMed abstract 10930412 22 PubMed abstract 11121022 23 PubMed abstract 12361945 24 PubMed abstract 12415108 25 PubMed abstract 14609956 26 PubMed abstract 14664718 27 PubMed abstract 12612053 28 PubMed abstract 16027218 29 PubMed abstract 16051670 30 PubMed abstract 17045208 31 PubMed abstract 17550981 32 PubMed abstract 10840043 33 PubMed abstract 11906285 34 PubMed abstract 15525515 35 PubMed abstract 15563469 36 PubMed abstract 16129672 37 PubMed abstract 16641486 38 PubMed abstract 18007036 39 PubMed abstract 17311914 40 PubMed abstract 17591767 41 PubMed abstract 17711855 42 PubMed abstract 17911242 43 PubMed abstract 1458719 44 PubMed abstract 8339746 45 PubMed abstract 8240973 46 PubMed abstract 7937057 47 PubMed abstract 7626493 48 PubMed abstract 9016528 49 PubMed abstract 2260966 50 PubMed abstract 2082179 51 PubMed abstract 1856263 52 PubMed abstract 1999491 53 PubMed abstract 2010552 54 PubMed abstract 2062380 55 PubMed abstract 1609793 56 PubMed abstract 1424203 57 PubMed abstract 1426313 58 PubMed abstract 1487249 59 PubMed abstract 1307250 60 PubMed abstract 1569163 61 PubMed abstract 1464650 62 PubMed abstract 1430233 63 PubMed abstract 1562539 64 PubMed abstract 1316540 65 PubMed abstract 1480178 66 PubMed abstract 1303262 67 PubMed abstract 1631125 68 PubMed abstract 8213813 69 PubMed abstract 8224266 70 PubMed abstract 8103398 71 PubMed abstract 8281139 72 PubMed abstract 8281140 73 PubMed abstract 8325932 74 PubMed abstract 8325950 75 PubMed abstract 8097257 76 PubMed abstract 8096390 77 PubMed abstract 8274409 78 PubMed abstract 8446106 79 PubMed abstract 8413310 80 PubMed abstract 8145761 81 PubMed abstract 7511268 82 PubMed abstract 8292051 83 PubMed abstract 8187068 84 PubMed abstract 7910529 85 PubMed abstract 7909256 86 PubMed abstract 8205256 87 PubMed abstract 8033918 88 PubMed abstract 8162033 89 PubMed abstract 7981687 90 PubMed abstract 7981689 91 PubMed abstract 8126121 92 PubMed abstract 7962294 93 PubMed abstract 8040309 94 PubMed abstract 7929841 95 PubMed abstract 7993455 96 PubMed abstract 7970939 97 PubMed abstract 8830623 98 PubMed abstract 7712463 99 PubMed abstract 7641413 100 PubMed abstract 7671849 101 PubMed abstract 7633398 102 PubMed abstract 7537149 103 PubMed abstract 7581399 104 PubMed abstract 7591265 105 PubMed abstract 7673412 106 PubMed abstract 8530589 107 PubMed abstract 7649358 108 PubMed abstract 7723794 109 PubMed abstract 8723113 110 PubMed abstract 9816170 111 PubMed abstract 9039340 112 PubMed abstract 9001799 113 PubMed abstract 8824883 114 PubMed abstract 8550758 115 PubMed abstract 8626869 116 PubMed abstract 8768864 117 PubMed abstract 8823308 118 PubMed abstract 8918984 119 PubMed abstract 8683794 120 PubMed abstract 8647313 121 PubMed abstract 8809734 122 PubMed abstract 8628719 123 PubMed abstract 8827083 124 PubMed abstract 9106550 125 PubMed abstract 9000575 126 PubMed abstract 9196614 127 PubMed abstract 9160185 128 PubMed abstract 9007482 129 PubMed abstract 8990010 130 PubMed abstract 9438000 131 PubMed abstract 9184448 132 PubMed abstract 9255042 133 PubMed abstract 9329414 134 PubMed abstract 9252933 135 PubMed abstract 9328206 136 PubMed abstract 9302173 137 PubMed abstract 9544375 138 PubMed abstract 9698822 139 PubMed abstract 9788719 140 PubMed abstract 9610419 141 PubMed abstract 9856504 142 PubMed abstract 9554754 143 PubMed abstract 9554755 144 PubMed abstract 9543136 145 PubMed abstract 9768671 146 PubMed abstract 9851768 147 PubMed abstract 9627582 148 PubMed abstract 9607727 149 PubMed abstract 10470409 150 PubMed abstract 10363963 151 PubMed abstract 10502786 152 PubMed abstract 10571951 153 PubMed abstract 10221692 154 PubMed abstract 10404311 155 PubMed abstract 10022458 156 PubMed abstract 10629558 157 PubMed abstract 10569618 158 PubMed abstract 10543676 159 PubMed abstract 10221770 160 PubMed abstract 10598582 161 PubMed abstract 10590024 162 PubMed abstract 10458483 163 PubMed abstract 10092153 164 PubMed abstract 10706109 165 PubMed abstract 10690872 166 PubMed abstract 11587068 167 PubMed abstract 11231320 168 PubMed abstract 11744994 169 PubMed abstract 15902657 170 PubMed abstract 16595706 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 367 |
| PDB ID | 1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2Z4J 3B5R 3B65 3B66 3B67 3B68 |
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