Reference: Chaudhary et., al., (2016) A Web Server and Mobile App for Computing Hemolytic Potency of Peptides. Sci Rep. 2016.
Quantitative Matrices of Hemolytic Peptides
Select the Quantitative Matrix to be displayed
Mono HemoPI-1 Di HemoPI-1 Mono HemoPI-2 Di HemoPI-2 Prop HemoPI-1 Prop HemoPI-2
QM represents the positional propensity of each residue/dipeptide at a particular position. QMs have been generated for HemoPI-1 and HemoPI-2 datasets; where propensity at each position for every residue is obtained by substracting the positional propensity of negative dataset from that of positive dataset in both ( HemoPI-1 & HemoPI-2 ) the datasets.
        
Color Notation for PM Score
< -16  
-16 to -14  
-14 to -12  
-12 to -10  
-10 to -8  
-8 to -6  
-6 to -4  
-4 to -2  
-2 to 0  
2 to 0  
4 to 2  
6 to 4  
8 to 6  
10 to 8  
12 to 10  
14 to 12  
16 to 14  
> 16  
Property-based QM for HemoPI-1 dataset. For each position frequency of residues falling into a particular category of physicochemical property (11 categories in total) is calculated for both positive and negative dataset and final propensity value represents the substraction of frequency of a residues in a particular class in negative dataset from that of positive dataset.eg. aliphatic and hydrophobic residues are preferred in positive datastes at most of the positions.
Pos Aliphatic charged Positive Negative Aromatic Hydrophobic Neutral Polar Tiny Small Large
1 1.60 -8.36 -4.65 -3.72 5.20 7.18 0.93 -8.11 -0.64 -2.99 3.64
2 13.31 -9.64 -6.47 -3.18 -0.19 14.05 -6.63 -7.42 -6.64 7.07 -0.42
3 1.57 -14.40 -16.43 2.04 4.95 8.07 7.05 -14.90 2.98 -1.74 -1.03
4 -4.67 -3.02 -3.40 0.38 0.92 1.53 1.38 -2.70 7.39 -5.75 -1.43
5 10.94 -7.03 -7.22 0.19 -3.79 9.86 -1.46 -7.52 6.03 3.70 -8.86
6 6.65 -12.12 -11.62 -0.50 2.56 13.89 -0.58 -12.18 5.78 -3.64 -1.02
7 2.59 -8.08 -5.39 -2.70 1.44 6.12 2.83 -6.93 3.68 -0.62 -1.04
8 4.29 -1.97 -2.60 0.63 0.75 5.23 1.13 -3.26 2.05 2.24 -1.19
9 10.94 -0.95 2.40 -3.36 5.58 17.26 -8.37 -2.54 -9.78 13.27 2.85
10 5.21 -5.40 -4.33 -1.07 -1.30 8.14 5.08 -5.37 5.90 4.17 -2.21
11 5.97 2.50 5.05 -2.55 2.02 9.75 -1.03 2.42 -0.99 10.23 1.90
12 12.61 -1.24 -2.19 0.95 0.01 12.07 1.18 -4.26 1.09 10.18 -2.28
13 18.55 -10.40 -9.90 -0.51 -3.51 19.42 3.59 -11.99 6.84 12.83 -8.65
14 4.94 -3.28 -2.34 -0.94 -0.95 5.01 5.41 -5.08 5.44 1.09 -1.19
15 -0.63 -1.13 0.42 -1.55 -4.40 2.15 3.14 3.25 10.39 -1.10 -0.75
16 9.33 1.50 0.79 0.71 0.79 9.03 1.49 -1.54 3.45 7.56 -2.03
17 10.09 -5.62 -4.44 -1.19 5.78 16.59 -3.77 -6.74 -1.98 3.99 4.05
18 -2.45 4.02 5.39 -1.37 2.74 0.25 3.67 3.62 2.87 0.08 4.59
19 0.83 3.35 1.64 1.71 0.27 1.99 -3.23 3.90 0.43 -0.12 2.34
20 6.23 0.54 0.65 -0.11 -0.75 6.90 -3.01 2.57 -0.36 8.22 -1.39
21 3.27 -0.07 -0.41 0.32 -0.45 3.54 3.85 0.50 4.90 3.88 -0.89
22 2.13 6.99 7.57 -0.58 -2.27 0.37 -1.12 6.34 -0.68 7.92 -1.65
23 3.14 3.47 3.58 -0.11 -1.11 4.64 -4.68 4.63 -1.47 4.94 1.10
24 2.52 1.04 1.83 -0.80 -2.52 4.01 -0.46 0.72 4.92 1.07 -1.72
25 -1.42 1.26 1.47 -0.21 2.44 -2.20 4.92 1.58 0.97 0.85 2.47
26 -2.61 2.49 2.91 -0.43 -0.25 -3.76 4.44 4.26 3.84 -0.53 1.64
27 0.47 0.27 -0.86 1.12 -1.47 -0.99 -2.53 5.13 -1.26 4.41 -1.54
28 0.77 -1.54 -1.07 -0.47 0.19 -0.34 3.54 -0.70 3.43 -0.44 -0.49
29 1.22 -1.18 -1.29 0.11 -0.04 0.60 1.90 -2.22 0.92 -0.28 -0.36
30 -0.86 0.08 0.55 -0.47 -0.07 -2.40 1.25 0.52 -2.72 2.38 -0.29