Reference: Chaudhary et., al., (2016) A Web Server and Mobile App for Computing Hemolytic Potency of Peptides. Sci Rep. 2016.

Updated version HemoPI2 is available

Quantitative Matrices of Hemolytic Peptides
Select the Quantitative Matrix to be displayed
Mono HemoPI-1 Di HemoPI-1 Mono HemoPI-2 Di HemoPI-2 Prop HemoPI-1 Prop HemoPI-2
QM represents the positional propensity of each residue/dipeptide at a particular position. QMs have been generated for HemoPI-1 and HemoPI-2 datasets; where propensity at each position for every residue is obtained by substracting the positional propensity of negative dataset from that of positive dataset in both ( HemoPI-1 & HemoPI-2 ) the datasets.
        
Color Notation for PM Score
< -16  
-16 to -14  
-14 to -12  
-12 to -10  
-10 to -8  
-8 to -6  
-6 to -4  
-4 to -2  
-2 to 0  
2 to 0  
4 to 2  
6 to 4  
8 to 6  
10 to 8  
12 to 10  
14 to 12  
16 to 14  
> 16  
Single residue-based QM for HemoPI-1 dataset. For each position, frequency of each amino acid is calculated for both positive and negative dataset and final propensity value in each cell represents the substraction of frequency of a particular residue in negative dataset from that of positive dataset. eg. First cell having value -3.26 represents that Alanine at 1st position is more preferred in negative dataset of HemoPI-1 dataset. In contrast, F and G are preferred in positive dataset at 1st position.
Res 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
A -3.26 -5.43 -4.35 -2.35 -3.44 -4.53 -4.35 -2.72 3.80 10.51 -4.53 -0.54 3.08 5.44 1.63 -2.53 1.81 -0.54 -1.09 1.08 1.26 0.00 -0.18 -0.73 -0.72 0.54 -1.08 2.17 1.09 0.91
C 3.08 2.36 -0.54 4.17 2.90 2.90 0.00 2.72 2.54 2.53 5.61 -0.18 2.90 1.45 3.45 0.54 2.35 2.35 3.99 1.64 2.36 0.18 1.64 3.63 0.36 1.09 1.45 0.55 0.54 0.00
D -5.62 -5.26 -5.26 -3.98 -2.54 -5.80 -6.70 -2.17 -7.61 -3.45 -5.98 -4.35 -4.53 -3.81 -4.89 -0.18 -2.18 -2.54 0.36 -2.90 -2.90 -2.36 -1.09 -1.82 -0.55 0.18 0.73 -0.36 0.55 -0.18
E -5.98 -5.07 -3.26 -7.25 -6.16 -4.16 -5.44 -5.44 -3.63 -6.53 -5.80 -5.07 -7.79 -6.16 -5.44 -3.44 -4.53 -2.90 -2.90 -3.99 -3.26 -2.72 -2.90 -0.18 -0.73 -1.09 -1.09 -1.27 0.18 -0.18
F 12.32 5.98 1.09 0.55 8.88 6.52 0.18 2.36 3.26 -1.08 -2.72 1.81 1.45 -0.37 3.26 0.00 4.52 0.00 -0.18 -0.36 -1.27 -0.37 -0.19 -1.27 -0.37 -0.54 -0.18 -0.72 0.00 -0.36
G 14.13 -1.09 9.06 -0.90 -2.36 -1.81 -2.36 4.52 -2.90 -0.73 -1.09 -3.63 3.63 -1.27 0.00 0.36 0.00 0.55 -1.81 0.91 -1.26 1.09 0.90 -1.27 0.37 -1.81 0.91 1.09 -0.91 -0.18
H -1.81 -1.09 -0.72 0.18 -1.27 -3.44 -1.63 -2.18 -1.81 -0.91 0.90 1.45 -0.18 -0.91 0.54 0.36 1.08 1.45 -1.09 0.55 -0.18 -1.45 0.18 -0.54 0.73 -0.55 -0.18 0.00 -0.36 0.00
I 2.17 0.72 -5.25 -1.26 1.81 6.70 -1.99 1.81 0.73 0.55 1.82 1.63 -0.18 -2.72 -0.54 0.18 -0.18 -2.35 0.36 1.99 0.73 -1.08 -2.00 0.36 -0.18 -2.17 -0.55 -0.18 2.17 0.00
K 13.77 1.09 9.42 16.84 11.60 3.44 23.37 15.58 8.33 5.25 19.39 10.87 1.81 7.24 13.95 8.70 1.27 8.52 7.61 3.08 1.45 7.43 4.35 2.72 2.00 1.63 -0.72 0.36 0.36 1.27
L -0.91 25.55 7.97 2.17 10.87 17.21 2.53 1.27 12.14 -0.18 5.26 5.43 14.13 9.61 1.45 4.16 5.43 1.45 -0.36 3.80 2.35 -1.08 0.54 -2.17 2.53 0.36 -1.45 0.72 0.00 0.00
M -1.63 -1.27 0.00 -0.90 -1.99 -0.54 -1.63 -2.18 -1.09 -1.99 -1.09 -1.09 -1.81 -1.81 -1.63 -1.09 -1.63 -1.45 0.18 -0.55 1.26 -0.73 0.18 -0.36 0.18 -0.54 0.00 -0.36 0.00 -0.18
N -3.99 0.19 -3.99 -2.89 -3.62 -3.99 -3.08 -1.82 -1.45 -3.63 -1.81 0.18 -3.44 -2.36 1.45 -0.36 -0.55 -0.91 -2.18 0.91 -0.54 -0.36 0.91 -1.45 -1.82 0.00 4.17 -0.54 0.55 0.18
P -3.80 -3.26 7.06 -4.34 -1.99 -3.44 -0.37 -3.99 1.09 -0.55 -1.27 -3.62 -3.26 0.37 -4.71 -3.62 -1.81 -1.45 -1.27 -2.36 -0.72 -0.55 -0.72 1.27 -1.09 -0.54 -0.36 -0.54 0.37 2.54
Q -2.90 -4.17 -3.99 -4.89 -3.45 -2.72 -5.43 -4.17 -2.00 -3.81 -3.99 -3.08 -2.90 -2.35 -1.45 -2.89 -1.27 -1.81 -1.63 0.00 -1.09 -0.54 0.00 0.36 -0.18 0.36 -0.73 0.54 -0.54 -1.09
R -0.90 -1.27 -2.36 2.90 0.00 -0.37 5.98 -2.54 -0.90 0.36 3.08 0.18 1.08 0.54 -0.36 -2.90 -0.73 1.99 -1.09 -1.27 -1.63 0.55 -0.18 0.54 1.45 0.91 -0.55 0.54 -1.09 -0.36
S -2.18 -7.24 -2.72 7.24 -6.88 -3.08 -1.27 -3.62 -5.62 1.09 0.91 -0.37 -1.09 -2.72 0.00 -1.45 -1.45 3.62 0.18 0.36 1.63 0.00 0.55 1.27 0.36 1.63 -0.36 0.18 0.00 0.37
T -4.34 -7.07 -3.63 -5.07 2.36 -4.17 -3.62 2.35 -4.17 -1.63 -3.08 -2.17 -0.37 -3.26 0.37 1.82 -1.63 -0.91 1.81 0.72 2.17 0.36 -1.82 0.72 -1.09 0.73 0.55 -0.18 -0.19 0.36
V -5.43 -3.81 -7.07 -3.62 -3.26 -0.55 -2.72 -1.45 -1.63 3.62 -5.80 1.99 3.08 3.80 -1.81 3.63 0.91 -3.45 -1.81 0.90 0.90 2.54 0.91 0.18 0.18 -0.18 -1.09 0.36 0.91 0.55
W 0.37 13.59 8.88 5.25 0.00 5.07 5.97 5.25 4.35 3.08 3.08 1.09 -0.18 1.27 0.55 0.37 -0.18 1.63 1.63 0.55 0.18 -0.18 0.55 -0.36 -0.36 0.00 -0.54 -0.36 0.00 0.00
Y -3.08 -3.44 -0.37 -1.81 -1.27 -2.90 3.08 -2.72 -2.53 -2.35 -2.89 -1.09 -2.36 -1.81 -1.27 -1.63 -0.37 -1.27 -0.91 -1.09 -1.45 -1.09 -0.37 0.73 2.18 0.00 0.00 0.55 0.00 0.18