Reference: Chaudhary et., al., (2016) A Web Server and Mobile App for Computing Hemolytic Potency of Peptides. Sci Rep. 2016.
Quantitative Matrices of Hemolytic Peptides
Select the Quantitative Matrix to be displayed
Mono HemoPI-1 Di HemoPI-1 Mono HemoPI-2 Di HemoPI-2 Prop HemoPI-1 Prop HemoPI-2
QM represents the positional propensity of each residue/dipeptide at a particular position. QMs have been generated for HemoPI-1 and HemoPI-2 datasets; where propensity at each position for every residue is obtained by substracting the positional propensity of negative dataset from that of positive dataset in both ( HemoPI-1 & HemoPI-2 ) the datasets.
        
Color Notation for PM Score
< -16  
-16 to -14  
-14 to -12  
-12 to -10  
-10 to -8  
-8 to -6  
-6 to -4  
-4 to -2  
-2 to 0  
2 to 0  
4 to 2  
6 to 4  
8 to 6  
10 to 8  
12 to 10  
14 to 12  
16 to 14  
> 16  
Single residue-based QM for HemoPI-1 dataset. For each position, frequency of each amino acid is calculated for both positive and negative dataset and final propensity value in each cell represents the substraction of frequency of a particular residue in negative dataset from that of positive dataset. eg. First cell having value -3.26 represents that Alanine at 1st position is more preferred in negative dataset of HemoPI-1 dataset. In contrast, F and G are preferred in positive dataset at 1st position.
Res 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
A -3.26 -5.43 -4.35 -2.35 -3.44 -4.53 -4.35 -2.72 3.80 10.51 -4.53 -0.54 3.08 5.44 1.63 -2.53 1.81 -0.54 -1.09 1.08 1.26 0.00 -0.18 -0.73 -0.72 0.54 -1.08 2.17 1.09 0.91
C 3.08 2.36 -0.54 4.17 2.90 2.90 0.00 2.72 2.54 2.53 5.61 -0.18 2.90 1.45 3.45 0.54 2.35 2.35 3.99 1.64 2.36 0.18 1.64 3.63 0.36 1.09 1.45 0.55 0.54 0.00
D -5.62 -5.26 -5.26 -3.98 -2.54 -5.80 -6.70 -2.17 -7.61 -3.45 -5.98 -4.35 -4.53 -3.81 -4.89 -0.18 -2.18 -2.54 0.36 -2.90 -2.90 -2.36 -1.09 -1.82 -0.55 0.18 0.73 -0.36 0.55 -0.18
E -5.98 -5.07 -3.26 -7.25 -6.16 -4.16 -5.44 -5.44 -3.63 -6.53 -5.80 -5.07 -7.79 -6.16 -5.44 -3.44 -4.53 -2.90 -2.90 -3.99 -3.26 -2.72 -2.90 -0.18 -0.73 -1.09 -1.09 -1.27 0.18 -0.18
F 12.32 5.98 1.09 0.55 8.88 6.52 0.18 2.36 3.26 -1.08 -2.72 1.81 1.45 -0.37 3.26 0.00 4.52 0.00 -0.18 -0.36 -1.27 -0.37 -0.19 -1.27 -0.37 -0.54 -0.18 -0.72 0.00 -0.36
G 14.13 -1.09 9.06 -0.90 -2.36 -1.81 -2.36 4.52 -2.90 -0.73 -1.09 -3.63 3.63 -1.27 0.00 0.36 0.00 0.55 -1.81 0.91 -1.26 1.09 0.90 -1.27 0.37 -1.81 0.91 1.09 -0.91 -0.18
H -1.81 -1.09 -0.72 0.18 -1.27 -3.44 -1.63 -2.18 -1.81 -0.91 0.90 1.45 -0.18 -0.91 0.54 0.36 1.08 1.45 -1.09 0.55 -0.18 -1.45 0.18 -0.54 0.73 -0.55 -0.18 0.00 -0.36 0.00
I 2.17 0.72 -5.25 -1.26 1.81 6.70 -1.99 1.81 0.73 0.55 1.82 1.63 -0.18 -2.72 -0.54 0.18 -0.18 -2.35 0.36 1.99 0.73 -1.08 -2.00 0.36 -0.18 -2.17 -0.55 -0.18 2.17 0.00
K 13.77 1.09 9.42 16.84 11.60 3.44 23.37 15.58 8.33 5.25 19.39 10.87 1.81 7.24 13.95 8.70 1.27 8.52 7.61 3.08 1.45 7.43 4.35 2.72 2.00 1.63 -0.72 0.36 0.36 1.27
L -0.91 25.55 7.97 2.17 10.87 17.21 2.53 1.27 12.14 -0.18 5.26 5.43 14.13 9.61 1.45 4.16 5.43 1.45 -0.36 3.80 2.35 -1.08 0.54 -2.17 2.53 0.36 -1.45 0.72 0.00 0.00
M -1.63 -1.27 0.00 -0.90 -1.99 -0.54 -1.63 -2.18 -1.09 -1.99 -1.09 -1.09 -1.81 -1.81 -1.63 -1.09 -1.63 -1.45 0.18 -0.55 1.26 -0.73 0.18 -0.36 0.18 -0.54 0.00 -0.36 0.00 -0.18
N -3.99 0.19 -3.99 -2.89 -3.62 -3.99 -3.08 -1.82 -1.45 -3.63 -1.81 0.18 -3.44 -2.36 1.45 -0.36 -0.55 -0.91 -2.18 0.91 -0.54 -0.36 0.91 -1.45 -1.82 0.00 4.17 -0.54 0.55 0.18
P -3.80 -3.26 7.06 -4.34 -1.99 -3.44 -0.37 -3.99 1.09 -0.55 -1.27 -3.62 -3.26 0.37 -4.71 -3.62 -1.81 -1.45 -1.27 -2.36 -0.72 -0.55 -0.72 1.27 -1.09 -0.54 -0.36 -0.54 0.37 2.54
Q -2.90 -4.17 -3.99 -4.89 -3.45 -2.72 -5.43 -4.17 -2.00 -3.81 -3.99 -3.08 -2.90 -2.35 -1.45 -2.89 -1.27 -1.81 -1.63 0.00 -1.09 -0.54 0.00 0.36 -0.18 0.36 -0.73 0.54 -0.54 -1.09
R -0.90 -1.27 -2.36 2.90 0.00 -0.37 5.98 -2.54 -0.90 0.36 3.08 0.18 1.08 0.54 -0.36 -2.90 -0.73 1.99 -1.09 -1.27 -1.63 0.55 -0.18 0.54 1.45 0.91 -0.55 0.54 -1.09 -0.36
S -2.18 -7.24 -2.72 7.24 -6.88 -3.08 -1.27 -3.62 -5.62 1.09 0.91 -0.37 -1.09 -2.72 0.00 -1.45 -1.45 3.62 0.18 0.36 1.63 0.00 0.55 1.27 0.36 1.63 -0.36 0.18 0.00 0.37
T -4.34 -7.07 -3.63 -5.07 2.36 -4.17 -3.62 2.35 -4.17 -1.63 -3.08 -2.17 -0.37 -3.26 0.37 1.82 -1.63 -0.91 1.81 0.72 2.17 0.36 -1.82 0.72 -1.09 0.73 0.55 -0.18 -0.19 0.36
V -5.43 -3.81 -7.07 -3.62 -3.26 -0.55 -2.72 -1.45 -1.63 3.62 -5.80 1.99 3.08 3.80 -1.81 3.63 0.91 -3.45 -1.81 0.90 0.90 2.54 0.91 0.18 0.18 -0.18 -1.09 0.36 0.91 0.55
W 0.37 13.59 8.88 5.25 0.00 5.07 5.97 5.25 4.35 3.08 3.08 1.09 -0.18 1.27 0.55 0.37 -0.18 1.63 1.63 0.55 0.18 -0.18 0.55 -0.36 -0.36 0.00 -0.54 -0.36 0.00 0.00
Y -3.08 -3.44 -0.37 -1.81 -1.27 -2.90 3.08 -2.72 -2.53 -2.35 -2.89 -1.09 -2.36 -1.81 -1.27 -1.63 -0.37 -1.27 -0.91 -1.09 -1.45 -1.09 -0.37 0.73 2.18 0.00 0.00 0.55 0.00 0.18