dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: UTY |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 8012774 PANCREAS c.1777delC p.H593fs*111 COSMIC NP NP 2 BN44T LIVER c.430C>A p.H144N COSMIC PASSENGER/OTHER Benign 3 CLL168 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1264C>T p.P422S COSMIC PASSENGER/OTHER Possibly Damaging 4 HCC73T LIVER c.395G>T p.G132V COSMIC PASSENGER/OTHER Probably Damaging 5 ICGC_0036 PANCREAS c.1777delC p.H593fs*111 COSMIC NP NP 6 LC_S15 LUNG c.2252A>T p.H751L COSMIC CANCER Probably Damaging 7 LUAD-CHTN-MAD06-00668 LUNG c.129G>A p.R43R COSMIC NP NP 8 S00947 LUNG c.3430C>G p.L1144V COSMIC PASSENGER/OTHER Possibly Damaging 9 S01563 LUNG c.1979G>T p.G660V COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-05-4403-01 LUNG c.1403G>C p.R468P COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-21-1081-01 LUNG c.3846G>T p.E1282D COSMIC PASSENGER/OTHER Probably Damaging 12 TCGA-46-6025-01 LUNG c.1911T>C p.N637N COSMIC NP NP 13 TCGA-49-4486-01 LUNG c.3751C>T p.Q1251* COSMIC NP NP 14 TCGA-AA-3510-01 LARGE INTESTINE c.1169G>T p.R390I COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-AD-6964-01 LARGE INTESTINE c.3909A>T p.V1303V COSMIC NP NP 16 TCGA-B2-5633-01 KIDNEY c.3170C>A p.A1057E COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-CA-6717-01 LARGE INTESTINE c.3955T>G p.F1319V COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-DK-A1AA-01 URINARY TRACT c.124G>T p.E42* COSMIC NP NP 19 TCGA-GV-A3QH-01 URINARY TRACT c.1719G>A p.L573L COSMIC NP NP 20 TCGA-GV-A3QH-01 URINARY TRACT c.2793C>G p.F931L COSMIC PASSENGER/OTHER Probably Damaging 21 YUPAT SKIN c.3272C>T p.P1091L COSMIC PASSENGER/OTHER Possibly Damaging 22 pfg016T STOMACH c.3786A>G p.K1262K COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB002066 Pfam-B_2066 1 49 4.4e-33 PF00515 TPR_1 127 160 0.00051 PF13181 TPR_8 204 230 0.1 PF13431 TPR_17 270 300 7.1e-05 PF13414 TPR_11 315 375 1.4e-06 PB000604 Pfam-B_604 580 717 2.6e-40 PB002513 Pfam-B_2513 663 804 8e-10 PB000972 Pfam-B_972 718 1056 1.3e-192 PF02373 JmjC 1080 1188 1.1e-33 2. Superfamily Domains:Domain ID Start Site End Site E-value 0047105 904 992 3.57e-44 0051253 145 330 1.90e-23 0049644 314 375 2.47e-08 0046495 72 158 4.93e-06 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Homologus sequences are not present!! -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR UTY UTY UTY ENSP00000330446 O14607 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O14607 UTY ENSP00000330446 UTY O14607 Expression Atlas Protein Atlas OMIM IntAct PharmGKB UTY ENSP00000330446 400009 O14607 PA37263
