A Database of Epigenetic Modifiers
Protein: TET1 |
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# | Cell Line/Tumor sample | Tissue of Origin | cDNA change | Protein change | Source | FATHMM Prediction | PolyPhen2 Prediction |
---|---|---|---|---|---|---|---|
1 | 22RV1 | PROSTATE | c.1768C>T | p.R590* | CCLE | NP | NP |
2 | BL41 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.5509G>T | p.A1837S | CCLE | PASSENGER/OTHER | Benign |
3 | CAKI1 | KIDNEY | c.4467_4467delA | p.L1489fs | CCLE | NP | NP |
4 | CL34 | LARGE INTESTINE | c.4780C>T | p.P1594S | CCLE | PASSENGER/OTHER | Benign |
5 | CMLT1 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.6127C>T | p.R2043C | CCLE | PASSENGER/OTHER | Probably Damaging |
6 | COLO818 | SKIN | c.4055C>G | p.T1352S | CCLE | PASSENGER/OTHER | Benign |
7 | CW2 | LARGE INTESTINE | c.242G>A | p.R81H | CCLE | PASSENGER/OTHER | Probably Damaging |
8 | DMS53 | LUNG | c.1774_1775GG>TT | p.G592L | CCLE | PASSENGER/OTHER | Probably Damaging |
9 | DMS53 | LUNG | c.4775G>T | p.R1592I | CCLE | PASSENGER/OTHER | Possibly Damaging |
10 | EFO27 | OVARY | c.986T>G | p.F329C | CCLE | PASSENGER/OTHER | Possibly Damaging |
11 | EN | ENDOMETRIUM | c.344T>C | p.L115P | CCLE | PASSENGER/OTHER | Probably Damaging |
12 | EN | ENDOMETRIUM | c.66_67insA | p.K22fs | CCLE | NP | NP |
13 | GCT | SOFT TISSUE | c.3386C>T | p.S1129L | CCLE | PASSENGER/OTHER | Benign |
14 | GP2D | LARGE INTESTINE | c.986T>C | p.F329S | CCLE | PASSENGER/OTHER | Benign |
15 | GSS | STOMACH | c.4182T>A | p.N1394K | CCLE | PASSENGER/OTHER | Benign |
16 | HCC1143 | BREAST | c.2617G>A | p.V873I | CCLE | PASSENGER/OTHER | Possibly Damaging |
17 | HCT15 | LARGE INTESTINE | c.1336C>T | p.P446S | CCLE | PASSENGER/OTHER | Benign |
18 | HCT15 | LARGE INTESTINE | c.242G>A | p.R81H | CCLE | PASSENGER/OTHER | Probably Damaging |
19 | HCT15 | LARGE INTESTINE | c.530A>C | p.N177T | CCLE | PASSENGER/OTHER | Benign |
20 | HEC108 | ENDOMETRIUM | c.1348C>G | p.P450A | CCLE | PASSENGER/OTHER | Probably Damaging |
21 | HEC108 | ENDOMETRIUM | c.3646T>G | p.S1216A | CCLE | PASSENGER/OTHER | Benign |
22 | HEC108 | ENDOMETRIUM | c.5376C>A | p.N1792K | CCLE | PASSENGER/OTHER | Benign |
23 | HEC1A | ENDOMETRIUM | c.1525C>T | p.P509S | CCLE | PASSENGER/OTHER | Probably Damaging |
24 | HEC1B | ENDOMETRIUM | c.1525C>T | p.P509S | CCLE | PASSENGER/OTHER | Probably Damaging |
25 | HEC251 | ENDOMETRIUM | c.4181A>C | p.N1394T | CCLE | PASSENGER/OTHER | Benign |
26 | HEC251 | ENDOMETRIUM | c.4206C>A | p.F1402L | CCLE | PASSENGER/OTHER | Benign |
27 | HEC251 | ENDOMETRIUM | c.4235C>T | p.S1412F | CCLE | PASSENGER/OTHER | Probably Damaging |
28 | HEC251 | ENDOMETRIUM | c.4864C>T | p.R1622* | CCLE | NP | NP |
29 | HRT18 | LARGE INTESTINE | c.1336C>T | p.P446S | CCLE | PASSENGER/OTHER | Benign |
30 | HRT18 | LARGE INTESTINE | c.242G>A | p.R81H | CCLE | PASSENGER/OTHER | Probably Damaging |
31 | HRT18 | LARGE INTESTINE | c.4318C>A | p.L1440I | CCLE | PASSENGER/OTHER | Probably Damaging |
32 | HRT18 | LARGE INTESTINE | c.530A>C | p.N177T | CCLE | PASSENGER/OTHER | Benign |
33 | HT115 | LARGE INTESTINE | c.1516A>C | p.S506R | CCLE | PASSENGER/OTHER | Benign |
34 | HT115 | LARGE INTESTINE | c.2003A>C | p.K668T | CCLE | PASSENGER/OTHER | Benign |
35 | HT115 | LARGE INTESTINE | c.3429G>T | p.K1143N | CCLE | PASSENGER/OTHER | Probably Damaging |
36 | HT55 | LARGE INTESTINE | c.558A>T | p.Q186H | CCLE | PASSENGER/OTHER | Probably Damaging |
37 | JHUEM7 | ENDOMETRIUM | c.4206C>A | p.F1402L | CCLE | PASSENGER/OTHER | Benign |
38 | KG1 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.1534A>G | p.T512A | CCLE | PASSENGER/OTHER | Benign |
39 | KNS62 | LUNG | c.3214C>T | p.Q1072* | CCLE | NP | NP |
40 | KYM1 | SOFT TISSUE | c.879A>T | p.E293D | CCLE | PASSENGER/OTHER | Benign |
41 | L428 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.3596G>A | p.G1199E | CCLE | PASSENGER/OTHER | Probably Damaging |
42 | LC1SQSF | LUNG | c.1153C>T | p.H385Y | CCLE | PASSENGER/OTHER | Benign |
43 | LOVO | LARGE INTESTINE | c.2765G>T | p.R922I | CCLE | PASSENGER/OTHER | Benign |
44 | LS411N | LARGE INTESTINE | c.4340C>T | p.A1447V | CCLE | PASSENGER/OTHER | Probably Damaging |
45 | MDAMB453 | BREAST | c.5794G>A | p.E1932K | CCLE | PASSENGER/OTHER | Probably Damaging |
46 | MDAMB453 | BREAST | c.5950G>A | p.E1984K | CCLE | PASSENGER/OTHER | Benign |
47 | MDAPCA2B | PROSTATE | c.1334C>G | p.A445G | CCLE | PASSENGER/OTHER | Benign |
48 | MEWO | SKIN | c.1510C>T | p.H504Y | CCLE | PASSENGER/OTHER | Possibly Damaging |
49 | MEWO | SKIN | c.2870C>T | p.P957L | CCLE | PASSENGER/OTHER | Benign |
50 | MHHCALL2 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.986T>G | p.F329C | CCLE | PASSENGER/OTHER | Possibly Damaging |
51 | NCIH1184 | LUNG | c.4411T>A | p.Y1471N | CCLE | PASSENGER/OTHER | Probably Damaging |
52 | NCIH1623 | LUNG | c.1792C>A | p.Q598K | CCLE | PASSENGER/OTHER | Probably Damaging |
53 | NCIH1781 | LUNG | c.6223A>T | p.N2075Y | CCLE | PASSENGER/OTHER | Possibly Damaging |
54 | NCIH1838 | LUNG | c.49G>A | p.D17N | CCLE | PASSENGER/OTHER | Benign |
55 | NCIH2110 | LUNG | c.4736G>A | p.C1579Y | CCLE | PASSENGER/OTHER | Possibly Damaging |
56 | NCIH2342 | LUNG | c.5348G>A | p.R1783Q | CCLE | PASSENGER/OTHER | Probably Damaging |
57 | NCIH510 | LUNG | c.5300C>T | p.A1767V | CCLE | PASSENGER/OTHER | Benign |
58 | OC316 | OVARY | c.4914G>T | p.Q1638H | CCLE | PASSENGER/OTHER | Probably Damaging |
59 | OCIAML3 | HAEMATOPOIETIC AND LYMPHOID TISSUE | c.2482C>T | p.P828S | CCLE | PASSENGER/OTHER | Possibly Damaging |
60 | RERFGC1B | STOMACH | c.793A>G | p.N265D | CCLE | PASSENGER/OTHER | Possibly Damaging |
61 | RKO | LARGE INTESTINE | c.4826_4826delA | p.E1609fs | CCLE | NP | NP |
62 | SKMEL2 | SKIN | c.4412A>G | p.Y1471C | CCLE | PASSENGER/OTHER | Probably Damaging |
63 | SKUT1 | SOFT TISSUE | c.58_58delA | p.K20fs | CCLE | NP | NP |
64 | SNU1040 | LARGE INTESTINE | c.3692A>G | p.Q1231R | CCLE | PASSENGER/OTHER | Benign |
65 | SNU1040 | LARGE INTESTINE | c.5614T>G | p.F1872V | CCLE | PASSENGER/OTHER | Benign |
66 | SNU175 | LARGE INTESTINE | c.5222G>A | p.R1741H | CCLE | PASSENGER/OTHER | Possibly Damaging |
67 | SNU46 | UPPER AERODIGESTIVE TRACT | c.32G>C | p.R11T | CCLE | PASSENGER/OTHER | Benign |
68 | SNU475 | LIVER | c.1981A>C | p.N661H | CCLE | PASSENGER/OTHER | Benign |
69 | SNU81 | LARGE INTESTINE | c.5132A>G | p.Y1711C | CCLE | PASSENGER/OTHER | Probably Damaging |
70 | SNU81 | LARGE INTESTINE | c.6386C>T | p.A2129V | CCLE | PASSENGER/OTHER | Probably Damaging |
71 | SNU81 | LARGE INTESTINE | c.973T>C | p.S325P | CCLE | PASSENGER/OTHER | Probably Damaging |
72 | SNU886 | LIVER | c.1348C>G | p.P450A | CCLE | PASSENGER/OTHER | Probably Damaging |
73 | SW480 | LARGE INTESTINE | c.719C>A | p.P240Q | CCLE | PASSENGER/OTHER | Benign |
74 | SW48 | LARGE INTESTINE | c.3319C>T | p.L1107F | CCLE | PASSENGER/OTHER | Probably Damaging |
75 | TUHR10TKB | KIDNEY | c.6382G>A | p.V2128I | CCLE | PASSENGER/OTHER | Probably Damaging |
76 | 104104 | BREAST | c.3927T>A | p.C1309* | COSMIC | NP | NP |
77 | 111995 | PROSTATE | c.985T>G | p.F329V | COSMIC | PASSENGER/OTHER | Benign |
78 | 112295 | LUNG | c.5656G>C | p.G1886R | COSMIC | PASSENGER/OTHER | Possibly Damaging |
79 | 266 | UPPER AERODIGESTIVE TRACT | c.919C>A | p.P307T | COSMIC | PASSENGER/OTHER | Possibly Damaging |
80 | 94699 | LUNG | c.5143G>A | p.D1715N | COSMIC | PASSENGER/OTHER | Benign |
81 | HN_62506 | UPPER AERODIGESTIVE TRACT | c.5347C>A | p.R1783R | COSMIC | NP | NP |
82 | HN_62686 | UPPER AERODIGESTIVE TRACT | c.5537C>T | p.P1846L | COSMIC | PASSENGER/OTHER | Possibly Damaging |
83 | TCGA-13-0804-01 | OVARY | c.3769G>T | p.V1257F | COSMIC | PASSENGER/OTHER | Benign |
84 | TCGA-13-0884-01 | OVARY | c.3621T>G | p.P1207P | COSMIC | NP | NP |
85 | TCGA-13-0899-01 | OVARY | c.6067G>A | p.A2023T | COSMIC | PASSENGER/OTHER | Probably Damaging |
86 | TCGA-24-0966-01 | OVARY | c.5118T>A | p.H1706Q | COSMIC | PASSENGER/OTHER | Probably Damaging |
87 | TCGA-24-1545-01 | OVARY | c.4513C>T | p.R1505C | COSMIC | PASSENGER/OTHER | Probably Damaging |
88 | TCGA-AA-3864-01 | LARGE INTESTINE | c.4325C>T | p.A1442V | COSMIC | PASSENGER/OTHER | Probably Damaging |
89 | TCGA-AA-A00J-01 | LARGE INTESTINE | c.5650C>T | p.P1884S | COSMIC | PASSENGER/OTHER | Benign |
90 | TCGA-AA-A00L-01 | LARGE INTESTINE | c.3518G>A | p.R1173Q | COSMIC | PASSENGER/OTHER | Benign |
91 | TCGA-AA-A01Q-01 | LARGE INTESTINE | c.4580T>C | p.L1527P | COSMIC | PASSENGER/OTHER | Benign |
92 | TCGA-AA-A022-01 | LARGE INTESTINE | c.2276G>A | p.G759D | COSMIC | PASSENGER/OTHER | Probably Damaging |
93 | TCGA-AG-A002-01 | LARGE INTESTINE | c.1288C>A | p.P430T | COSMIC | PASSENGER/OTHER | Benign |
94 | TCGA-AG-A002-01 | LARGE INTESTINE | c.4235C>A | p.S1412Y | COSMIC | PASSENGER/OTHER | Probably Damaging |
95 | TCGA-AG-A00C-01 | LARGE INTESTINE | c.4693G>T | p.G1565* | COSMIC | NP | NP |
96 | TCGA-AG-A020-01 | LARGE INTESTINE | c.2052A>C | p.K684N | COSMIC | PASSENGER/OTHER | Benign |
Modelled Structure | Structures available in PDB |
Structure is not available in PDB |
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S. No. | Position | Amino acid | Type |
Proteomics DB | COSMIC | Gene Atlas | STRING | PIR |
TET1 | TET1 | TET1 | ENSP00000362748 | Q8NFU7 |
QuickGO | HGNC | Ensembl Genome Browser | TreeFam | UniProt |
Q8NFU7 | TET1 | ENSP00000362748 | TET1 | Q8NFU7 |
Expression Atlas | Protein Atlas | OMIM | IntAct | PharmGKB |
TET1 | ENSP00000362748 | 607790 | Q8NFU7 | PA162405605 |