dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 24T SKIN c.247C>T p.Q83* COSMIC NP NP 2 266 UPPER AERODIGESTIVE TRACT c.827C>T p.T276M COSMIC PASSENGER/OTHER Benign 3 LAU165 SKIN c.284C>T p.P95L COSMIC PASSENGER/OTHER Probably Damaging 4 MZ7-mel SKIN c.324C>T p.V108V COSMIC NP NP 5 OV207 OVARY c.4C>T p.R2* COSMIC NP NP 6 PA195 PANCREAS c.714G>C p.E238D COSMIC PASSENGER/OTHER Possibly Damaging 7 PD3856a BREAST c.787C>G p.Q263E COSMIC PASSENGER/OTHER Benign 8 TCGA-13-2061-01 OVARY c.766C>G p.P256A COSMIC PASSENGER/OTHER Probably Damaging 9 TCGA-21-1076-01 LUNG c.405C>T p.V135V COSMIC NP NP 10 TCGA-AA-3672-01 LARGE INTESTINE c.576T>C p.P192P COSMIC NP NP 11 TCGA-AA-3715-01 LARGE INTESTINE c.358G>A p.A120T COSMIC PASSENGER/OTHER Probably Damaging 12 TCGA-AD-6895-01 LARGE INTESTINE c.657C>T p.H219H COSMIC NP NP 13 TCGA-AD-6964-01 LARGE INTESTINE c.440G>A p.R147H COSMIC PASSENGER/OTHER Benign 14 TCGA-AG-3892-01 LARGE INTESTINE c.131G>A p.R44Q COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-AP-A059-01 ENDOMETRIUM c.356G>A p.R119H COSMIC PASSENGER/OTHER Possibly Damaging 16 TCGA-AP-A0LM-01 ENDOMETRIUM c.881G>A p.G294E COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AR-A1AH-01 BREAST c.618G>C p.R206R COSMIC NP NP 18 TCGA-AX-A0J0-01 ENDOMETRIUM c.504T>C p.S168S COSMIC NP NP 19 TCGA-B5-A0JY-01 ENDOMETRIUM c.130C>T p.R44* COSMIC NP NP 20 TCGA-BK-A0C9-01 ENDOMETRIUM c.249G>T p.Q83H COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-BS-A0UF-01 ENDOMETRIUM c.716T>G p.L239R COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-D1-A103-01 ENDOMETRIUM c.851G>T p.R284I COSMIC PASSENGER/OTHER Benign 23 TCGA-G2-A2EO-01 URINARY TRACT c.420G>A p.Q140Q COSMIC NP NP 24 YULAN SKIN c.460C>T p.L154F COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SIRT5 SIRT5 SIRT5 ENSP00000352830 Q9NXA8 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NXA8 SIRT5 ENSP00000352830 SIRT5 Q9NXA8 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SIRT5 ENSP00000352830 604483 Q9NXA8 PA37938
