dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587220 LARGE INTESTINE c.45G>T p.W15C COSMIC PASSENGER/OTHER Possibly Damaging 2 587376 LARGE INTESTINE c.1154A>C p.D385A COSMIC PASSENGER/OTHER Benign 3 ESO-717 OESOPHAGUS c.540delT p.F180fs*93 COSMIC NP NP 4 J82 URINARY TRACT c.1179G>A p.K393K COSMIC NP NP 5 LUAD-NYU847 LUNG c.978T>G p.P326P COSMIC NP NP 6 LUAD-S01302 LUNG c.659G>T p.G220V COSMIC PASSENGER/OTHER Probably Damaging 7 LUAD-VUMN6 LUNG c.1080G>T p.V360V COSMIC NP NP 8 MEL-Ma-Mel-54a SKIN c.636_637insT p.L213fs*6 COSMIC NP NP 9 NB-0192 AUTONOMIC GANGLIA c.793G>T p.G265W COSMIC PASSENGER/OTHER Probably Damaging 10 S00936 LUNG c.399G>T p.R133R COSMIC NP NP 11 TCGA-21-1081-01 LUNG c.649C>A p.H217N COSMIC PASSENGER/OTHER Possibly Damaging 12 TCGA-23-1029-01 OVARY c.1168G>A p.E390K COSMIC PASSENGER/OTHER Possibly Damaging 13 TCGA-36-2534-01 OVARY c.120T>A p.L40L COSMIC NP NP 14 TCGA-49-4501-01 LUNG c.862A>G p.K288E COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-66-2795-01 LUNG c.1167G>T p.R389R COSMIC NP NP 16 TCGA-AD-6889-01 LARGE INTESTINE c.455G>A p.S152N COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AF-6136-01 LARGE INTESTINE c.436delG p.A146fs*127 COSMIC NP NP 18 TCGA-AP-A051-01 ENDOMETRIUM c.1034G>A p.R345Q COSMIC PASSENGER/OTHER Possibly Damaging 19 TCGA-AP-A051-01 ENDOMETRIUM c.996G>T p.E332D COSMIC PASSENGER/OTHER Benign 20 TCGA-AP-A0LM-01 ENDOMETRIUM c.856G>A p.V286I COSMIC PASSENGER/OTHER Benign 21 TCGA-AP-A0LV-01 ENDOMETRIUM c.561C>A p.H187Q COSMIC PASSENGER/OTHER Benign 22 TCGA-B5-A11E-01 ENDOMETRIUM c.366G>T p.K122N COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-CM-4743-01 LARGE INTESTINE c.872T>G p.I291S COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-CM-4746-01 LARGE INTESTINE c.1107C>T p.G369G COSMIC NP NP 25 TCGA-D5-6928-01 LARGE INTESTINE c.322G>A p.A108T COSMIC PASSENGER/OTHER Benign 26 TCGA-DM-A1D4-01 LARGE INTESTINE c.1178A>G p.K393R COSMIC PASSENGER/OTHER Possibly Damaging 27 TCGA-EW-A1IZ-01 BREAST c.490C>A p.L164M COSMIC PASSENGER/OTHER Probably Damaging 28 YULAPE SKIN c.292G>A p.G98R COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SIRT3 SIRT3 SIRT3 ENSP00000372191 Q9NTG7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NTG7 SIRT3 ENSP00000372191 SIRT3 Q9NTG7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SIRT3 ENSP00000372191 604481 Q9NTG7 PA37936
