dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETDB2 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 Br27P CENTRAL NERVOUS SYSTEM c.956C>T p.P319L COSMIC PASSENGER/OTHER Possibly Damaging 2 HN_62921 UPPER AERODIGESTIVE TRACT c.414G>A p.S138S COSMIC NP NP 3 K48 KIDNEY c.365T>A p.L122H COSMIC PASSENGER/OTHER Possibly Damaging 4 KM12 LARGE INTESTINE c.1621A>G p.S541G COSMIC PASSENGER/OTHER Probably Damaging 5 LC_S18 LUNG c.182delT p.I61fs*8 COSMIC NP NP 6 LUAD-NYU330 LUNG c.1636G>A p.D546N COSMIC PASSENGER/OTHER Benign 7 LUAD-S00488 LUNG c.557C>T p.A186V COSMIC PASSENGER/OTHER Probably Damaging 8 PACA2440 PANCREAS c.1930G>A p.G644R COSMIC PASSENGER/OTHER Probably Damaging 9 RK126_C01 LIVER c.99G>C p.Q33H COSMIC PASSENGER/OTHER Benign 10 RK209_C01 LIVER c.1397A>G p.N466S COSMIC PASSENGER/OTHER Benign 11 SA054 BREAST c.994_995delAA p.R333fs*11 COSMIC NP NP 12 TCGA-05-4405-01 LUNG c.222A>C p.K74N COSMIC PASSENGER/OTHER Benign 13 TCGA-23-1026-01 OVARY c.1172C>A p.T391K COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-50-6593-01 LUNG c.268G>C p.E90Q COSMIC PASSENGER/OTHER Possibly Damaging 15 TCGA-55-7281-01 LUNG c.28A>G p.T10A COSMIC PASSENGER/OTHER Benign 16 TCGA-86-6851-01 LUNG c.1663G>C p.E555Q COSMIC PASSENGER/OTHER Benign 17 TCGA-95-7043-01 LUNG c.1959T>A p.S653R COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-AA-A00A-01 LARGE INTESTINE c.158T>C p.M53T COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-AG-A002-01 LARGE INTESTINE c.508A>C p.K170Q COSMIC PASSENGER/OTHER Possibly Damaging 20 TCGA-AG-A02N-01 LARGE INTESTINE c.1075C>T p.R359* COSMIC NP NP 21 TCGA-AP-A056-01 ENDOMETRIUM c.1268A>C p.K423T COSMIC PASSENGER/OTHER Benign 22 TCGA-AP-A0LM-01 ENDOMETRIUM c.1634T>C p.V545A COSMIC PASSENGER/OTHER Benign 23 TCGA-AP-A0LM-01 ENDOMETRIUM c.603C>T p.N201N COSMIC NP NP 24 TCGA-AU-6004-01 LARGE INTESTINE c.1245C>T p.N415N COSMIC NP NP 25 TCGA-AX-A05Z-01 ENDOMETRIUM c.666T>A p.F222L COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-B5-A0JY-01 ENDOMETRIUM c.1877C>A p.S626Y COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-B5-A0K9-01 ENDOMETRIUM c.546T>C p.S182S COSMIC NP NP 28 TCGA-B5-A11E-01 ENDOMETRIUM c.284C>T p.S95F COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-B5-A11E-01 ENDOMETRIUM c.644A>C p.N215T COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-B5-A11E-01 ENDOMETRIUM c.677C>A p.T226N COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-B5-A11N-01 ENDOMETRIUM c.1185T>G p.I395M COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-BG-A0M9-01 ENDOMETRIUM c.1126C>A p.Q376K COSMIC PASSENGER/OTHER Benign 33 TCGA-BS-A0UF-01 ENDOMETRIUM c.433C>A p.H145N COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-BS-A0UV-01 ENDOMETRIUM c.715G>T p.E239* COSMIC NP NP 35 TCGA-CA-6717-01 LARGE INTESTINE c.665T>G p.F222C COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-CM-6161-01 LARGE INTESTINE c.1173A>G p.T391T COSMIC NP NP 37 TCGA-CM-6171-01 LARGE INTESTINE c.955C>T p.P319S COSMIC PASSENGER/OTHER Benign 38 TCGA-D1-A15X-01 ENDOMETRIUM c.1704T>A p.T568T COSMIC NP NP 39 TCGA-D1-A17Q-01 ENDOMETRIUM c.1196G>A p.R399K COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-D1-A17Q-01 ENDOMETRIUM c.414G>A p.S138S COSMIC NP NP 41 TCGA-D1-A17Q-01 ENDOMETRIUM c.715G>T p.E239* COSMIC NP NP 42 TCGA-D1-A17U-01 ENDOMETRIUM c.833G>A p.R278Q COSMIC CANCER Probably Damaging 43 TCGA-DS-A0VN-01 CERVIX c.52G>A p.D18N COSMIC PASSENGER/OTHER Benign 44 TCGA-EO-A1Y8-01 ENDOMETRIUM c.695G>A p.R232Q COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-EW-A1IZ-01 BREAST c.676A>G p.T226A COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-F4-6856-01 LARGE INTESTINE c.1510delA p.M506fs*24 COSMIC NP NP 47 YUKADI SKIN c.2017C>T p.P673S COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETDB2 SETDB2 SETDB2 ENSP00000326477 Q96T68 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q96T68 SETDB2 ENSP00000326477 SETDB2 Q96T68 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETDB2 ENSP00000326477 607865 Q96T68 PA134956285
