dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETD7 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.209G>A p.G70D COSMIC CANCER Probably Damaging 2 587376 LARGE INTESTINE c.7A>C p.S3R COSMIC PASSENGER/OTHER Probably Damaging 3 BN24T LIVER c.142C>T p.R48W COSMIC PASSENGER/OTHER Probably Damaging 4 Br27P CENTRAL NERVOUS SYSTEM c.916G>A p.D306N COSMIC PASSENGER/OTHER Probably Damaging 5 ESO-0079 OESOPHAGUS c.1044A>C p.E348D COSMIC PASSENGER/OTHER Possibly Damaging 6 ESO-866 OESOPHAGUS c.1046C>T p.A349V COSMIC PASSENGER/OTHER Probably Damaging 7 HN_62646 UPPER AERODIGESTIVE TRACT c.1030A>G p.K344E COSMIC PASSENGER/OTHER Benign 8 LC_S29 LUNG c.304G>T p.G102W COSMIC PASSENGER/OTHER Probably Damaging 9 LUAD-CHTN-Z4716A LUNG c.250G>T p.G84C COSMIC PASSENGER/OTHER Probably Damaging 10 LUAD-D01382 LUNG c.607A>T p.T203S COSMIC PASSENGER/OTHER Benign 11 LUAD-NYU608 LUNG c.640G>A p.E214K COSMIC PASSENGER/OTHER Benign 12 RK035_C01 LIVER c.684A>G p.E228E COSMIC NP NP 13 TCGA-24-1470-01 OVARY c.1028G>T p.G343V COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-80-5611-01 LUNG c.607A>T p.T203S COSMIC PASSENGER/OTHER Benign 15 TCGA-A3-3346-01 KIDNEY c.592T>C p.S198P COSMIC PASSENGER/OTHER Benign 16 TCGA-A5-A0VP-01 ENDOMETRIUM c.959G>A p.R320H COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-A6-6780-01 LARGE INTESTINE c.657T>C p.A219A COSMIC NP NP 18 TCGA-AA-3558-01 LARGE INTESTINE c.874G>T p.G292* COSMIC NP NP 19 TCGA-AA-3663-01 LARGE INTESTINE c.916G>A p.D306N COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-AA-3877-01 LARGE INTESTINE c.344G>A p.R115H COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AD-6964-01 LARGE INTESTINE c.460G>A p.A154T COSMIC PASSENGER/OTHER Benign 22 TCGA-AG-A002-01 LARGE INTESTINE c.244C>A p.L82I COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-AO-A03L-01 BREAST c.373G>A p.D125N COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AP-A059-01 ENDOMETRIUM c.419C>A p.T140N COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-AX-A0J0-01 ENDOMETRIUM c.746G>A p.R249Q COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AZ-4315-01 LARGE INTESTINE c.477T>G p.F159L COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-B5-A0JR-01 ENDOMETRIUM c.934C>T p.R312C COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-BS-A0UF-01 ENDOMETRIUM c.170G>T p.S57I COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-CK-4952-01 LARGE INTESTINE c.916G>A p.D306N COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-CK-6746-01 LARGE INTESTINE c.255G>A p.T85T COSMIC NP NP 31 TCGA-D5-6928-01 LARGE INTESTINE c.460G>A p.A154T COSMIC PASSENGER/OTHER Benign 32 TCGA-D8-A1XG-01 BREAST c.223A>T p.T75S COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-EI-6507-01 LARGE INTESTINE c.1026delC p.K344fs*14 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB 1H3I, 1MT6, 1MUF, 1N6A, 1N6C, 1O9S, 1XQH, 2F69, 3CBM, 3CBO, 3CBP, 3M53, 3M54, 3M55, 3M56, 3M57, 3M58, 3M59, 3M5A, 3OS5, 3VUZ, 3VV0, 4E47, 4J7F, 4J7I, 4J83, 4J8O, 4JDS, 4JLG, -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETD7 SETD7 SETD7 ENSP00000274031 Q8WTS6 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8WTS6 SETD7 ENSP00000274031 SETD7 Q8WTS6 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETD7 ENSP00000274031 606594 Q8WTS6 PA143485615
