dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETD6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587278 LARGE INTESTINE c.91C>T p.R31W COSMIC PASSENGER/OTHER Probably Damaging 2 ESO-0950 OESOPHAGUS c.529G>T p.D177Y COSMIC NP NP 3 ESO-838 OESOPHAGUS c.1128G>C p.L376L COSMIC NP NP 4 HCC35T LIVER c.895T>G p.L299V COSMIC NP NP 5 LC_C13 LUNG c.1130C>T p.T377M COSMIC NP NP 6 LC_C13 LUNG c.551G>A p.R184H COSMIC NP NP 7 TCGA-05-4403-01 LUNG c.272C>T p.A91V COSMIC NP Benign 8 TCGA-13-0795-01 OVARY c.983G>A p.G328E COSMIC NP NP 9 TCGA-49-4490-01 LUNG c.625G>C p.E209Q COSMIC NP NP 10 TCGA-A5-A0GP-01 ENDOMETRIUM c.941G>A p.R314H COSMIC NP NP 11 TCGA-AD-5900-01 LARGE INTESTINE c.1221delA p.T409fs*31 COSMIC NP NP 12 TCGA-AG-3726-01 LARGE INTESTINE c.891A>G p.A297A COSMIC NP NP 13 TCGA-AP-A051-01 ENDOMETRIUM c.491A>G p.Y164C COSMIC NP NP 14 TCGA-AP-A056-01 ENDOMETRIUM c.730C>T p.R244W COSMIC NP NP 15 TCGA-AP-A059-01 ENDOMETRIUM c.1206C>T p.T402T COSMIC NP NP 16 TCGA-AP-A059-01 ENDOMETRIUM c.501C>T p.I167I COSMIC NP NP 17 TCGA-AP-A059-01 ENDOMETRIUM c.987C>A p.A329A COSMIC NP NP 18 TCGA-B0-5399-01 KIDNEY c.647C>G p.S216C COSMIC NP NP 19 TCGA-B5-A0JV-01 ENDOMETRIUM c.508C>T p.P170S COSMIC NP NP 20 TCGA-CA-6718-01 LARGE INTESTINE c.831A>G p.E277E COSMIC NP NP 21 TCGA-D1-A103-01 ENDOMETRIUM c.1125C>T p.S375S COSMIC NP NP 22 TCGA-D1-A103-01 ENDOMETRIUM c.639G>A p.E213E COSMIC NP NP 23 TCGA-FD-A3B6-01 URINARY TRACT c.1164G>C p.W388C COSMIC NP NP 24 TCGA-G2-A2EL-01 URINARY TRACT c.1114G>A p.E372K COSMIC NP Probably Damaging 25 TCGA-G2-A2EL-01 URINARY TRACT c.637G>C p.E213Q COSMIC NP NP 26 cSCCP6 SKIN c.569A>C p.H190P COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETD6 SETD6 SETD6 ENSP00000219315 Q8TBK2 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8TBK2 SETD6 ENSP00000219315 SETD6 Q8TBK2 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETD6 ENSP00000219315 NA Q8TBK2 PA143485614
