dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: RUVBL1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 CP66-MEL SKIN c.306C>T p.Y102Y COSMIC NP NP 2 HN_62421 UPPER AERODIGESTIVE TRACT c.948C>A p.H316Q COSMIC PASSENGER/OTHER Benign 3 LUAD-5V8LT LUNG c.1099A>T p.T367S COSMIC PASSENGER/OTHER Benign 4 LUAD-S01315 LUNG c.405C>T p.V135V COSMIC NP NP 5 LUAD-S01315 LUNG c.556G>T p.E186* COSMIC NP NP 6 ME050T SKIN c.1361A>T p.Y454F COSMIC PASSENGER/OTHER Benign 7 T155 ENDOMETRIUM c.634G>T p.E212* COSMIC NP NP 8 TCGA-33-6737-01 LUNG c.1026G>T p.E342D COSMIC PASSENGER/OTHER Benign 9 TCGA-34-5239-01 LUNG c.51C>T p.S17S COSMIC NP NP 10 TCGA-43-5668-01 LUNG c.368G>T p.R123L COSMIC PASSENGER/OTHER Possibly Damaging 11 TCGA-44-2656-01 LUNG c.141G>T p.E47D COSMIC PASSENGER/OTHER Probably Damaging 12 TCGA-53-7624-01 LUNG c.114G>A p.G38G COSMIC NP NP 13 TCGA-55-7574-01 LUNG c.813C>G p.I271M COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-66-2792-01 LUNG c.532G>T p.E178* COSMIC NP NP 15 TCGA-78-7162-01 LUNG c.979G>A p.V327I COSMIC PASSENGER/OTHER Benign 16 TCGA-78-7166-01 LUNG c.476T>G p.I159R COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-78-7167-01 LUNG c.72G>A p.L24L COSMIC NP NP 18 TCGA-A6-2672-01 LARGE INTESTINE c.490G>A p.A164T COSMIC PASSENGER/OTHER Benign 19 TCGA-AA-3560-01 LARGE INTESTINE c.1249G>C p.A417P COSMIC PASSENGER/OTHER Possibly Damaging 20 TCGA-AA-3715-01 LARGE INTESTINE c.349C>T p.R117C COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AA-3864-01 LARGE INTESTINE c.349C>T p.R117C COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AA-A00N-01 LARGE INTESTINE c.1291G>A p.E431K COSMIC PASSENGER/OTHER Benign 23 TCGA-AA-A022-01 LARGE INTESTINE c.551G>A p.R184Q COSMIC PASSENGER/OTHER Benign 24 TCGA-AG-3598-01 LARGE INTESTINE c.746G>A p.R249Q COSMIC PASSENGER/OTHER Benign 25 TCGA-AG-A002-01 LARGE INTESTINE c.1122C>T p.I374I COSMIC NP NP 26 TCGA-AG-A002-01 LARGE INTESTINE c.1291G>A p.E431K COSMIC PASSENGER/OTHER Benign 27 TCGA-B5-A11E-01 ENDOMETRIUM c.1107G>T p.Q369H COSMIC PASSENGER/OTHER Benign 28 TCGA-B8-4151-01 KIDNEY c.794A>G p.K265R COSMIC PASSENGER/OTHER Benign 29 TCGA-BH-A0DX-01 BREAST c.928G>A p.E310K COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-BS-A0UV-01 ENDOMETRIUM c.697G>T p.E233* COSMIC NP NP 31 TCGA-BT-A20J-01 URINARY TRACT c.241C>T p.L81L COSMIC NP NP 32 TCGA-CM-4746-01 LARGE INTESTINE c.743C>T p.A248V COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-D1-A165-01 ENDOMETRIUM c.744G>A p.A248A COSMIC NP NP 34 TCGA-DK-A3IS-01 URINARY TRACT c.110C>T p.S37L COSMIC PASSENGER/OTHER Benign 35 TCGA-E2-A155-01 BREAST c.1272C>T p.S424S COSMIC NP NP 36 TCGA-G2-A3IE-01 URINARY TRACT c.1235C>T p.P412L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR RUVBL1 RUVBL1 RUVBL1 ENSP00000318297 Q9Y265 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y265 RUVBL1 ENSP00000318297 RUVBL1 Q9Y265 Expression Atlas Protein Atlas OMIM IntAct PharmGKB RUVBL1 ENSP00000318297 603449 Q9Y265 PA34887
