dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT7 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587342 LARGE INTESTINE c.1058C>A p.P353H COSMIC PASSENGER/OTHER Benign 2 B10 URINARY TRACT c.1965C>G p.A655A COSMIC NP NP 3 Capan-1 PANCREAS c.959T>C p.F320S COSMIC PASSENGER/OTHER Probably Damaging 4 ESO-H63 OESOPHAGUS c.1963G>T p.A655S COSMIC PASSENGER/OTHER Benign 5 H1155 LUNG c.2063C>T p.A688V COSMIC PASSENGER/OTHER Benign 6 HCC132T LIVER c.751G>A p.D251N COSMIC PASSENGER/OTHER Benign 7 LC_C28 LUNG c.410G>A p.R137H COSMIC PASSENGER/OTHER Probably Damaging 8 LUAD-NYU1142 LUNG c.464C>T p.A155V COSMIC PASSENGER/OTHER Probably Damaging 9 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.701C>T p.S234L COSMIC PASSENGER/OTHER Benign 10 PA285 PANCREAS c.796C>T p.R266W COSMIC PASSENGER/OTHER Possibly Damaging 11 S00945 LUNG c.1144A>C p.I382L COSMIC PASSENGER/OTHER Benign 12 TCGA-05-4433-01 LUNG c.1784G>A p.C595Y COSMIC PASSENGER/OTHER Benign 13 TCGA-21-5782-01 LUNG c.1948T>A p.Y650N COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-55-1594-01 LUNG c.1460C>T p.P487L COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-60-2698-01 LUNG c.616G>A p.G206R COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-60-2724-01 LUNG c.1816G>C p.G606R COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-63-5131-01 LUNG c.794G>T p.R265M COSMIC PASSENGER/OTHER Benign 18 TCGA-63-5131-01 LUNG c.796C>T p.R266W COSMIC PASSENGER/OTHER Possibly Damaging 19 TCGA-66-2778-01 LUNG c.22G>A p.A8T COSMIC PASSENGER/OTHER Benign 20 TCGA-78-7542-01 LUNG c.553G>T p.V185L COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-A5-A0R6-01 ENDOMETRIUM c.409C>T p.R137C COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AA-3525-01 LARGE INTESTINE c.245C>T p.A82V COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-AA-A010-01 LARGE INTESTINE c.134A>G p.N45S COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AD-6889-01 LARGE INTESTINE c.1372C>T p.R458W COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-AG-3580-01 LARGE INTESTINE c.640G>A p.V214I COSMIC PASSENGER/OTHER Benign 26 TCGA-AN-A0XR-01 BREAST c.1730C>G p.P577R COSMIC PASSENGER/OTHER Possibly Damaging 27 TCGA-AO-A0JL-01 BREAST c.1586G>A p.R529Q COSMIC PASSENGER/OTHER Possibly Damaging 28 TCGA-AP-A059-01 ENDOMETRIUM c.1168C>T p.R390* COSMIC NP NP 29 TCGA-AP-A059-01 ENDOMETRIUM c.151G>T p.G51C COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-AR-A24X-01 BREAST c.984G>T p.V328V COSMIC NP NP 31 TCGA-AX-A063-01 ENDOMETRIUM c.537C>T p.T179T COSMIC NP NP 32 TCGA-AX-A0J1-01 ENDOMETRIUM c.2037C>T p.G679G COSMIC NP NP 33 TCGA-AX-A1C8-01 ENDOMETRIUM c.1545C>T p.A515A COSMIC NP NP 34 TCGA-AZ-6601-01 LARGE INTESTINE c.1246G>A p.V416M COSMIC PASSENGER/OTHER Benign 35 TCGA-B0-4823-01 KIDNEY c.2056A>G p.R686G COSMIC PASSENGER/OTHER Benign 36 TCGA-B5-A11E-01 ENDOMETRIUM c.324G>T p.E108D COSMIC PASSENGER/OTHER Possibly Damaging 37 TCGA-BT-A3PH-01 URINARY TRACT c.1139G>C p.G380A COSMIC PASSENGER/OTHER Possibly Damaging 38 TCGA-CA-6716-01 LARGE INTESTINE c.663C>T p.G221G COSMIC NP NP 39 TCGA-CA-6718-01 LARGE INTESTINE c.507A>C p.E169D COSMIC PASSENGER/OTHER Benign 40 TCGA-D1-A103-01 ENDOMETRIUM c.2037C>T p.G679G COSMIC NP NP 41 TCGA-D1-A169-01 ENDOMETRIUM c.439G>A p.D147N COSMIC PASSENGER/OTHER Probably Damaging 42 TCGA-EW-A1PB-01 BREAST c.1359C>G p.N453K COSMIC PASSENGER/OTHER Benign 43 TCGA-F4-6856-01 LARGE INTESTINE c.1850A>G p.Y617C COSMIC PASSENGER/OTHER Possibly Damaging 44 TCGA-GV-A3JZ-01 URINARY TRACT c.1684G>C p.E562Q COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-GV-A3QG-01 URINARY TRACT c.26A>G p.N9S COSMIC PASSENGER/OTHER Probably Damaging 46 YUAVEY SKIN c.1201C>T p.P401S COSMIC PASSENGER/OTHER Benign 47 YUKLAB SKIN c.226G>A p.G76R COSMIC CANCER Probably Damaging 48 ccRCC-30 KIDNEY c.337A>T p.S113C COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT7 PRMT7 PRMT7 ENSP00000343103 Q9NVM4 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NVM4 PRMT7 ENSP00000343103 PRMT7 Q9NVM4 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT7 ENSP00000343103 610087 Q9NVM4 PA143485581
