dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 B085 BILIARY TRACT c.299A>G p.Y100C COSMIC NP Probably Damaging 2 BN20T LIVER c.823G>C p.D275H COSMIC NP NP 3 ESO-721 OESOPHAGUS c.495C>A p.G165G COSMIC NP NP 4 ESO-859 OESOPHAGUS c.316T>C p.S106P COSMIC NP NP 5 KM12 LARGE INTESTINE c.566C>T p.A189V COSMIC PASSENGER/OTHER Probably Damaging 6 LUAD-CHTN-MAD06-00668 LUNG c.299A>G p.Y100C COSMIC NP Probably Damaging 7 PA285 PANCREAS c.384C>A p.A128A COSMIC NP NP 8 TCGA-18-3416-01 LUNG c.569G>A p.R190Q COSMIC NP NP 9 TCGA-60-2720-01 LUNG c.752C>T p.S251L COSMIC NP NP 10 TCGA-64-5775-01 LUNG c.875G>C p.R292P COSMIC NP NP 11 TCGA-69-7980-01 LUNG c.49C>T p.R17W COSMIC NP NP 12 TCGA-73-4668-01 LUNG c.602G>T p.R201L COSMIC NP Benign 13 TCGA-78-7147-01 LUNG c.531C>G p.I177M COSMIC NP NP 14 TCGA-A8-A095-01 BREAST c.253G>C p.E85Q COSMIC NP NP 15 TCGA-AA-3947-01 LARGE INTESTINE c.264A>G p.E88E COSMIC NP NP 16 TCGA-AA-3947-01 LARGE INTESTINE c.384C>A p.A128A COSMIC NP NP 17 TCGA-AA-A010-01 LARGE INTESTINE c.366C>T p.G122G COSMIC NP NP 18 TCGA-AA-A01R-01 LARGE INTESTINE c.820C>T p.Q274* COSMIC NP NP 19 TCGA-AD-6895-01 LARGE INTESTINE c.843G>A p.E281E COSMIC NP NP 20 TCGA-AP-A056-01 ENDOMETRIUM c.428A>C p.E143A COSMIC NP NP 21 TCGA-AR-A0U2-01 BREAST c.763C>T p.P255S COSMIC NP NP 22 TCGA-AX-A05Z-01 ENDOMETRIUM c.900C>A p.Y300* COSMIC NP NP 23 TCGA-AX-A0J0-01 ENDOMETRIUM c.931G>T p.D311Y COSMIC NP NP 24 TCGA-B0-5110-01 KIDNEY c.46C>A p.L16I COSMIC NP NP 25 TCGA-B5-A11H-01 ENDOMETRIUM c.441_442insT p.W149fs*>169 COSMIC NP NP 26 TCGA-BT-A20T-01 URINARY TRACT c.286G>C p.E96Q COSMIC NP NP 27 TCGA-CA-5254-01 LARGE INTESTINE c.786G>A p.A262A COSMIC NP NP 28 TCGA-CI-6622-01 LARGE INTESTINE c.21C>T p.R7R COSMIC NP NP 29 TCGA-CM-4743-01 LARGE INTESTINE c.903A>C p.K301N COSMIC NP NP 30 TCGA-D1-A15X-01 ENDOMETRIUM c.787C>T p.L263F COSMIC PASSENGER/OTHER Benign 31 TCGA-DK-A1AC-01 URINARY TRACT c.705G>A p.V235V COSMIC NP NP 32 TCGA-EJ-7115-01 PROSTATE c.513C>T p.L171L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT6 PRMT6 PRMT6 ENSP00000359095 Q96LA8 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q96LA8 PRMT6 ENSP00000359095 PRMT6 Q96LA8 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT6 ENSP00000359095 608274 Q96LA8 PA134992775
