dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRDM9 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 020 HAEMATOPOIETIC AND LYMPHOID TISSUE c.827A>T p.Y276F COSMIC PASSENGER/OTHER Probably Damaging 2 020-0049-01TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.827A>T p.Y276F COSMIC PASSENGER/OTHER Probably Damaging 3 100 BREAST c.920G>A p.G307E COSMIC PASSENGER/OTHER Benign 4 100-02-2TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.920G>A p.G307E COSMIC PASSENGER/OTHER Benign 5 134427 LUNG c.2627G>C p.C876S COSMIC PASSENGER/OTHER Benign 6 2334187 LUNG c.1377G>T p.R459S COSMIC PASSENGER/OTHER Benign 7 2334201 LUNG c.1499C>A p.T500K COSMIC PASSENGER/OTHER Probably Damaging 8 585258 LUNG c.1544G>C p.G515A COSMIC PASSENGER/OTHER Benign 9 587228 LARGE INTESTINE c.696G>T p.K232N COSMIC PASSENGER/OTHER Probably Damaging 10 587232 LARGE INTESTINE c.2516G>A p.R839Q COSMIC PASSENGER/OTHER Possibly Damaging 11 587238 LARGE INTESTINE c.664C>T p.P222S COSMIC PASSENGER/OTHER Probably Damaging 12 587306 LARGE INTESTINE c.153T>A p.Y51* COSMIC NP NP 13 587332 LARGE INTESTINE c.338G>A p.R113H COSMIC PASSENGER/OTHER Possibly Damaging 14 587342 LARGE INTESTINE c.31C>A p.P11T COSMIC PASSENGER/OTHER Benign 15 587376 LARGE INTESTINE c.2506G>A p.E836K COSMIC PASSENGER/OTHER Possibly Damaging 16 587376 LARGE INTESTINE c.44C>T p.T15I COSMIC PASSENGER/OTHER Benign 17 587376 LARGE INTESTINE c.836G>A p.R279Q COSMIC PASSENGER/OTHER Benign 18 98711 LUNG c.122C>A p.A41E COSMIC PASSENGER/OTHER Benign 19 98735 LUNG c.1678G>T p.G560C COSMIC PASSENGER/OTHER Benign 20 CLL104 HAEMATOPOIETIC AND LYMPHOID TISSUE c.727C>A p.P243T COSMIC PASSENGER/OTHER Probably Damaging 21 Capan-1 PANCREAS c.504A>T p.K168N COSMIC PASSENGER/OTHER Probably Damaging 22 ESO-005 OESOPHAGUS c.631T>G p.F211V COSMIC PASSENGER/OTHER Possibly Damaging 23 ESO-0053 OESOPHAGUS c.724C>A p.L242M COSMIC PASSENGER/OTHER Probably Damaging 24 ESO-0149 OESOPHAGUS c.275A>G p.D92G COSMIC PASSENGER/OTHER Probably Damaging 25 ESO-0292 OESOPHAGUS c.2209A>G p.R737G COSMIC PASSENGER/OTHER Benign 26 ESO-077 OESOPHAGUS c.1766T>A p.F589Y COSMIC PASSENGER/OTHER Probably Damaging 27 ESO-1145 OESOPHAGUS c.1474A>C p.R492R COSMIC NP NP 28 ESO-1163 OESOPHAGUS c.475A>C p.S159R COSMIC PASSENGER/OTHER Benign 29 ESO-118 OESOPHAGUS c.2531A>C p.K844T COSMIC PASSENGER/OTHER Possibly Damaging 30 ESO-1608 OESOPHAGUS c.198C>T p.L66L COSMIC NP NP 31 ESO-169 OESOPHAGUS c.281A>C p.E94A COSMIC PASSENGER/OTHER Probably Damaging 32 ESO-2472 OESOPHAGUS c.1014G>T p.Q338H COSMIC PASSENGER/OTHER Possibly Damaging 33 ESO-717 OESOPHAGUS c.338G>T p.R113L COSMIC PASSENGER/OTHER Benign 34 ESO-913 OESOPHAGUS c.367T>C p.S123P COSMIC PASSENGER/OTHER Benign 35 ESOSCC152T OESOPHAGUS c.151T>C p.Y51H COSMIC PASSENGER/OTHER Probably Damaging 36 ESOSCC159T OESOPHAGUS c.2588G>A p.R863K COSMIC PASSENGER/OTHER Benign 37 H2171 LUNG c.697G>T p.G233W COSMIC PASSENGER/OTHER Probably Damaging 38 HN_00076 UPPER AERODIGESTIVE TRACT c.1050C>T p.G350G COSMIC NP NP 39 HN_00190 UPPER AERODIGESTIVE TRACT c.1398G>T p.R466S COSMIC PASSENGER/OTHER Benign 40 HN_62338 UPPER AERODIGESTIVE TRACT c.953A>T p.Y318F COSMIC PASSENGER/OTHER Possibly Damaging 41 HN_62415 UPPER AERODIGESTIVE TRACT c.2551C>A p.Q851K COSMIC PASSENGER/OTHER Possibly Damaging 42 HN_62421 UPPER AERODIGESTIVE TRACT c.1634C>G p.T545R COSMIC PASSENGER/OTHER Possibly Damaging 43 HN_62506 UPPER AERODIGESTIVE TRACT c.2259T>A p.C753* COSMIC NP NP 44 HN_62652 UPPER AERODIGESTIVE TRACT c.2273G>A p.R758H COSMIC PASSENGER/OTHER Possibly Damaging 45 HN_62739 UPPER AERODIGESTIVE TRACT c.321C>T p.A107A COSMIC NP NP 46 HN_62825 UPPER AERODIGESTIVE TRACT c.593A>T p.Q198L COSMIC PASSENGER/OTHER Probably Damaging 47 HN_62897 UPPER AERODIGESTIVE TRACT c.31C>A p.P11T COSMIC PASSENGER/OTHER Benign 48 HN_62921 UPPER AERODIGESTIVE TRACT c.104T>A p.F35Y COSMIC PASSENGER/OTHER Probably Damaging 49 LUAD-B02594 LUNG c.2576C>A p.P859H COSMIC PASSENGER/OTHER Probably Damaging 50 LUAD-CHTN-MAD06-00490 LUNG c.174T>A p.Y58* COSMIC NP NP 51 LUAD-CHTN-MAD06-00668 LUNG c.1749G>T p.R583S COSMIC PASSENGER/OTHER Benign 52 LUAD-CHTN-MAD06-00668 LUNG c.936G>T p.W312C COSMIC PASSENGER/OTHER Possibly Damaging 53 LUAD-CHTN-Z4716A LUNG c.1311G>T p.Q437H COSMIC PASSENGER/OTHER Possibly Damaging 54 LUAD-D01603 LUNG c.1465G>T p.V489L COSMIC PASSENGER/OTHER Possibly Damaging 55 LUAD-D01751 LUNG c.1068G>T p.W356C COSMIC PASSENGER/OTHER Probably Damaging 56 LUAD-E00443 LUNG c.967C>A p.R323R COSMIC NP NP 57 LUAD-E00897 LUNG c.19C>A p.Q7K COSMIC PASSENGER/OTHER Benign 58 LUAD-E00897 LUNG c.379G>T p.E127* COSMIC NP NP 59 LUAD-E00918 LUNG c.669A>T p.T223T COSMIC NP NP 60 LUAD-E00934 LUNG c.2275G>A p.D759N COSMIC PASSENGER/OTHER Possibly Damaging 61 LUAD-F00162 LUNG c.1801_1802delAC p.T603fs*15 COSMIC NP NP 62 LUAD-F00368 LUNG c.2651G>T p.G884V COSMIC PASSENGER/OTHER Probably Damaging 63 LUAD-NYU1021 LUNG c.1594G>C p.G532R COSMIC PASSENGER/OTHER Benign 64 LUAD-NYU284 LUNG c.842C>A p.T281K COSMIC PASSENGER/OTHER Probably Damaging 65 LUAD-NYU627 LUNG c.1093C>A p.L365M COSMIC PASSENGER/OTHER Probably Damaging 66 LUAD-RT-S01699 LUNG c.2408C>A p.P803H COSMIC PASSENGER/OTHER Probably Damaging 67 LUAD-RT-S01774 LUNG c.424delG p.A142fs*26 COSMIC NP NP 68 LUAD-RT-S01840 LUNG c.1457G>T p.S486I COSMIC PASSENGER/OTHER Possibly Damaging 69 LUAD-S00488 LUNG c.2298C>A p.H766Q COSMIC CANCER Probably Damaging 70 LUAD-S01302 LUNG c.2148G>A p.G716G COSMIC NP NP 71 LUAD-S01354 LUNG c.7C>A p.P3T COSMIC PASSENGER/OTHER Benign 72 LUAD-S01357 LUNG c.730C>T p.P244S COSMIC PASSENGER/OTHER Probably Damaging 73 LUAD-S01405 LUNG c.1548_1557del10 p.G517fs*>375 COSMIC NP NP 74 LUAD-S01405 LUNG c.1802C>G p.T601R COSMIC PASSENGER/OTHER Possibly Damaging 75 LUAD-S01409 LUNG c.2469G>T p.Q823H COSMIC PASSENGER/OTHER Probably Damaging 76 LUAD-U6SJ7 LUNG c.2315G>T p.G772V COSMIC PASSENGER/OTHER Probably Damaging 77 LUAD-VUMN6 LUNG c.799C>G p.L267V COSMIC PASSENGER/OTHER Probably Damaging 78 LUAD-YINHD LUNG c.582C>A p.V194V COSMIC NP NP 79 LUAD-YINHD LUNG c.942C>A p.N314K COSMIC PASSENGER/OTHER Probably Damaging 80 LUAD_E00565 LUNG c.2184C>A p.G728G COSMIC NP NP 81 LUAD_E00623 LUNG c.507G>T p.L169L COSMIC NP NP 82 MBRep_T56 CENTRAL NERVOUS SYSTEM c.561G>A p.K187K COSMIC NP NP 83 MD-290 CENTRAL NERVOUS SYSTEM c.2525G>A p.R842H COSMIC PASSENGER/OTHER Possibly Damaging 84 ME002T SKIN c.1119G>A p.W373* COSMIC NP NP 85 ME024T NS c.2358A>C p.R786S COSMIC PASSENGER/OTHER Benign 86 ME029T SKIN c.2023T>C p.W675R COSMIC PASSENGER/OTHER Benign 87 ME029T SKIN c.2527A>G p.N843D COSMIC PASSENGER/OTHER Benign 88 ME030T SKIN c.1802C>G p.T601R COSMIC PASSENGER/OTHER Possibly Damaging 89 ME030T SKIN c.2440A>C p.S814R COSMIC PASSENGER/OTHER Possibly Damaging 90 ME041T SKIN c.1337G>A p.S446N COSMIC PASSENGER/OTHER Benign 91 ME041T SKIN c.2527A>G p.N843D COSMIC PASSENGER/OTHER Benign 92 ME100L SKIN c.1790C>G p.T597S COSMIC PASSENGER/OTHER Benign 93 Mx30 LARGE INTESTINE c.1567A>G p.K523E COSMIC PASSENGER/OTHER Benign 94 Mx34 LARGE INTESTINE c.932C>A p.S311Y COSMIC PASSENGER/OTHER Possibly Damaging 95 NB-1110 AUTONOMIC GANGLIA c.209G>T p.R70L COSMIC PASSENGER/OTHER Possibly Damaging 96 OLID09 CENTRAL NERVOUS SYSTEM c.967C>T p.R323W COSMIC PASSENGER/OTHER Benign 97 P05-620 PROSTATE c.338G>A p.R113H COSMIC PASSENGER/OTHER Possibly Damaging 98 PA195 PANCREAS c.888C>G p.T296T COSMIC NP NP 99 PD4937a BREAST c.1078G>A p.E360K COSMIC PASSENGER/OTHER Probably Damaging 100 Pa09C PANCREAS c.1602T>G p.S534R COSMIC PASSENGER/OTHER Benign 101 S00050 LUNG c.2515C>A p.R839R COSMIC NP NP 102 S00356 LUNG c.1365G>T p.E455D COSMIC PASSENGER/OTHER Possibly Damaging 103 S00501 LUNG c.2138C>G p.T713R COSMIC PASSENGER/OTHER Possibly Damaging 104 S00501 LUNG c.2295A>T p.R765S COSMIC PASSENGER/OTHER Benign 105 S00539 LUNG c.410C>T p.A137V COSMIC PASSENGER/OTHER Possibly Damaging 106 S00836 LUNG c.803C>A p.P268Q COSMIC PASSENGER/OTHER Probably Damaging 107 S00837 LUNG c.1432A>C p.S478R COSMIC PASSENGER/OTHER Possibly Damaging 108 S00936 LUNG c.2114C>T p.S705L COSMIC PASSENGER/OTHER Possibly Damaging 109 S00944 LUNG c.25G>C p.E9Q COSMIC PASSENGER/OTHER Benign 110 S00945 LUNG c.2290C>T p.L764F COSMIC PASSENGER/OTHER Benign 111 S01563 LUNG c.1675C>A p.R559R COSMIC NP NP 112 TCGA-05-4244-01 LUNG c.2476C>A p.H826N COSMIC PASSENGER/OTHER Probably Damaging 113 TCGA-05-4398-01 LUNG c.2340G>T p.E780D COSMIC PASSENGER/OTHER Possibly Damaging 114 TCGA-05-4405-01 LUNG c.279A>T p.E93D COSMIC PASSENGER/OTHER Probably Damaging 115 TCGA-05-4410-01 LUNG c.1289C>A p.P430H COSMIC PASSENGER/OTHER Benign 116 TCGA-05-4417-01 LUNG c.847G>T p.D283Y COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-05-4430-01 LUNG c.2424G>T p.E808D COSMIC PASSENGER/OTHER Possibly Damaging 118 TCGA-05-5428-01 LUNG c.745G>T p.G249W COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-13-0910-01 OVARY c.1959T>C p.T653T COSMIC NP NP 120 TCGA-13-1411-01 OVARY c.101A>G p.Y34C COSMIC PASSENGER/OTHER Probably Damaging 121 TCGA-18-4083-01 LUNG c.2240C>A p.P747H COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-18-4083-01 LUNG c.2241C>A p.P747P COSMIC NP NP 123 TCGA-22-1002-01 LUNG c.208C>T p.R70* COSMIC NP NP 124 TCGA-22-4591-01 LUNG c.2573A>T p.K858M COSMIC PASSENGER/OTHER Probably Damaging 125 TCGA-22-4595-01 LUNG c.1034G>T p.R345L COSMIC PASSENGER/OTHER Probably Damaging 126 TCGA-22-4613-01 LUNG c.505C>A p.L169M COSMIC PASSENGER/OTHER Possibly Damaging 127 TCGA-22-5471-01 LUNG c.1834G>A p.E612K COSMIC PASSENGER/OTHER Benign 128 TCGA-24-1844-01 OVARY c.121G>A p.A41T COSMIC PASSENGER/OTHER Benign 129 TCGA-24-2289-01 OVARY c.2058C>G p.H686Q COSMIC PASSENGER/OTHER Possibly Damaging 130 TCGA-25-1319-01 OVARY c.2480C>G p.T827R COSMIC PASSENGER/OTHER Possibly Damaging 131 TCGA-25-1329-01 OVARY c.1148C>G p.P383R COSMIC PASSENGER/OTHER Possibly Damaging 132 TCGA-29-1761-01 OVARY c.478A>T p.T160S COSMIC PASSENGER/OTHER Benign 133 TCGA-29-1762-01 OVARY c.1855C>T p.R619W COSMIC PASSENGER/OTHER Benign 134 TCGA-33-4538-01 LUNG c.168G>T p.R56S COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-33-4566-01 LUNG c.1326A>T p.P442P COSMIC NP NP 136 TCGA-33-4566-01 LUNG c.765G>T p.Q255H COSMIC PASSENGER/OTHER Possibly Damaging 137 TCGA-33-4566-01 LUNG c.98T>A p.I33K COSMIC PASSENGER/OTHER Possibly Damaging 138 TCGA-34-5231-01 LUNG c.79G>T p.A27S COSMIC PASSENGER/OTHER Possibly Damaging 139 TCGA-35-4122-01 LUNG c.315G>T p.W105C COSMIC PASSENGER/OTHER Possibly Damaging 140 TCGA-38-4626-01 LUNG c.654C>G p.A218A COSMIC NP NP 141 TCGA-43-3920-01 LUNG c.1505A>T p.Q502L COSMIC PASSENGER/OTHER Probably Damaging 142 TCGA-43-3920-01 LUNG c.195T>C p.G65G COSMIC NP NP 143 TCGA-44-2657-01 LUNG c.66C>A p.P22P COSMIC NP NP 144 TCGA-44-2659-01 LUNG c.2478C>A p.H826Q COSMIC PASSENGER/OTHER Probably Damaging 145 TCGA-44-2659-01 LUNG c.307C>A p.P103T COSMIC PASSENGER/OTHER Possibly Damaging 146 TCGA-44-7671-01 LUNG c.2672G>T p.R891M COSMIC PASSENGER/OTHER Probably Damaging 147 TCGA-44-8117-01 LUNG c.1168T>C p.C390R COSMIC PASSENGER/OTHER Probably Damaging 148 TCGA-49-4490-01 LUNG c.603T>C p.D201D COSMIC NP NP 149 TCGA-49-6743-01 LUNG c.2399G>T p.G800V COSMIC PASSENGER/OTHER Probably Damaging 150 TCGA-49-6744-01 LUNG c.586G>A p.E196K COSMIC PASSENGER/OTHER Possibly Damaging 151 TCGA-50-5049-01 LUNG c.94T>A p.S32T COSMIC PASSENGER/OTHER Probably Damaging 152 TCGA-50-5066-01 LUNG c.2226C>G p.H742Q COSMIC PASSENGER/OTHER Probably Damaging 153 TCGA-50-5066-02 LUNG c.2226C>G p.H742Q COSMIC PASSENGER/OTHER Probably Damaging 154 TCGA-50-5933-01 LUNG c.1745G>T p.C582F COSMIC CANCER Probably Damaging 155 TCGA-50-5946-01 LUNG c.1757G>T p.G586V COSMIC PASSENGER/OTHER Probably Damaging 156 TCGA-50-5946-02 LUNG c.1757G>T p.G586V COSMIC PASSENGER/OTHER Probably Damaging 157 TCGA-50-5946-02 LUNG c.2496T>C p.Y832Y COSMIC NP NP 158 TCGA-50-6590-01 LUNG c.769G>A p.G257R COSMIC CANCER Probably Damaging 159 TCGA-50-6592-01 LUNG c.1682T>A p.F561Y COSMIC PASSENGER/OTHER Probably Damaging 160 TCGA-50-6593-01 LUNG c.1327G>A p.D443N COSMIC PASSENGER/OTHER Benign 161 TCGA-50-6593-01 LUNG c.1372G>T p.E458* COSMIC NP NP 162 TCGA-50-6593-01 LUNG c.1389G>A p.L463L COSMIC NP NP 163 TCGA-50-6593-01 LUNG c.1404G>A p.W468* COSMIC NP NP 164 TCGA-50-7109-01 LUNG c.1032C>T p.C344C COSMIC NP NP 165 TCGA-53-7624-01 LUNG c.110A>G p.K37R COSMIC PASSENGER/OTHER Probably Damaging 166 TCGA-55-1592-01 LUNG c.645C>T p.S215S COSMIC NP NP 167 TCGA-55-1596-01 LUNG c.1083C>A p.Y361* COSMIC NP NP 168 TCGA-55-6985-01 LUNG c.1821C>T p.P607P COSMIC NP NP 169 TCGA-55-6986-01 LUNG c.2598G>A p.G866G COSMIC NP NP 170 TCGA-55-7227-01 LUNG c.565C>T p.H189Y COSMIC PASSENGER/OTHER Possibly Damaging 171 TCGA-55-7281-01 LUNG c.663C>A p.P221P COSMIC NP NP 172 TCGA-55-7574-01 LUNG c.1794C>A p.H598Q COSMIC CANCER Probably Damaging 173 TCGA-55-7725-01 LUNG c.2496T>C p.Y832Y COSMIC NP NP 174 TCGA-55-7727-01 LUNG c.2496T>C p.Y832Y COSMIC NP NP 175 TCGA-55-7907-01 LUNG c.1524C>A p.N508K COSMIC PASSENGER/OTHER Benign 176 TCGA-55-7910-01 LUNG c.337C>A p.R113S COSMIC PASSENGER/OTHER Benign 177 TCGA-55-7911-01 LUNG c.519G>A p.K173K COSMIC NP NP 178 TCGA-60-2698-01 LUNG c.1475G>A p.R492K COSMIC PASSENGER/OTHER Benign 179 TCGA-60-2698-01 LUNG c.2373C>A p.L791L COSMIC NP NP 180 TCGA-60-2724-01 LUNG c.2244T>C p.Y748Y COSMIC NP NP 181 TCGA-61-1998-01 OVARY c.796G>A p.D266N COSMIC PASSENGER/OTHER Probably Damaging 182 TCGA-63-6202-01 LUNG c.2208C>A p.L736L COSMIC NP NP 183 TCGA-64-5775-01 LUNG c.18C>T p.S6S COSMIC NP NP 184 TCGA-66-2734-01 LUNG c.885C>A p.I295I COSMIC NP NP 185 TCGA-66-2754-01 LUNG c.368C>A p.S123* COSMIC NP NP 186 TCGA-69-7979-01 LUNG c.426A>C p.A142A COSMIC NP NP 187 TCGA-69-7979-01 LUNG c.428G>T p.S143I COSMIC PASSENGER/OTHER Possibly Damaging 188 TCGA-73-4666-01 LUNG c.434C>A p.S145* COSMIC NP NP 189 TCGA-73-4668-01 LUNG c.2317G>T p.E773* COSMIC NP NP 190 TCGA-73-7499-01 LUNG c.2001G>A p.R667R COSMIC NP NP 191 TCGA-78-7147-01 LUNG c.2255A>T p.E752V COSMIC PASSENGER/OTHER Benign 192 TCGA-78-7154-01 LUNG c.1142G>A p.R381K COSMIC PASSENGER/OTHER Possibly Damaging 193 TCGA-78-7166-01 LUNG c.2478C>A p.H826Q COSMIC PASSENGER/OTHER Probably Damaging 194 TCGA-78-7536-01 LUNG c.1746C>T p.C582C COSMIC NP NP 195 TCGA-78-7542-01 LUNG c.2313A>T p.T771T COSMIC NP NP 196 TCGA-85-6175-01 LUNG c.1759C>A p.R587R COSMIC NP NP 197 TCGA-86-6851-01 LUNG c.129G>T p.M43I COSMIC PASSENGER/OTHER Possibly Damaging 198 TCGA-86-7713-01 LUNG c.763C>A p.Q255K COSMIC PASSENGER/OTHER Benign 199 TCGA-91-7771-01 LUNG c.27G>T p.E9D COSMIC PASSENGER/OTHER Benign 200 TCGA-93-7347-01 LUNG c.1970G>C p.R657T COSMIC PASSENGER/OTHER Benign 201 TCGA-95-7043-01 LUNG c.1501_1502GG>TT p.G501F COSMIC PASSENGER/OTHER Probably Damaging 202 TCGA-97-7554-01 LUNG c.2198C>A p.S733* COSMIC NP NP 203 TCGA-97-7938-01 LUNG c.1248C>A p.F416L COSMIC PASSENGER/OTHER Benign 204 TCGA-99-8028-01 LUNG c.782G>A p.W261* COSMIC NP NP 205 TCGA-99-8032-01 LUNG c.1782C>A p.V594V COSMIC NP NP 206 TCGA-99-8033-01 LUNG c.2496T>C p.Y832Y COSMIC NP NP 207 TCGA-A5-A0GD-01 ENDOMETRIUM c.2379T>A p.S793R COSMIC PASSENGER/OTHER Benign 208 TCGA-A5-A0GV-01 ENDOMETRIUM c.2358A>C p.R786S COSMIC PASSENGER/OTHER Benign 209 TCGA-A6-3810-01 LARGE INTESTINE c.2179C>T p.R727W COSMIC PASSENGER/OTHER Possibly Damaging 210 TCGA-A6-6782-01 LARGE INTESTINE c.726G>T p.L242L COSMIC NP NP 211 TCGA-AA-3492-01 LARGE INTESTINE c.2011C>T p.R671W COSMIC PASSENGER/OTHER Probably Damaging 212 TCGA-AA-3510-01 LARGE INTESTINE c.550C>T p.R184* COSMIC NP NP 213 TCGA-AA-3672-01 LARGE INTESTINE c.1759C>T p.R587W COSMIC PASSENGER/OTHER Benign 214 TCGA-AA-3712-01 LARGE INTESTINE c.2479A>G p.T827A COSMIC PASSENGER/OTHER Benign 215 TCGA-AA-3715-01 LARGE INTESTINE c.1290C>A p.P430P COSMIC NP NP 216 TCGA-AA-3715-01 LARGE INTESTINE c.306A>G p.K102K COSMIC NP NP 217 TCGA-AA-3831-01 LARGE INTESTINE c.1383A>T p.K461N COSMIC PASSENGER/OTHER Possibly Damaging 218 TCGA-AA-3845-01 LARGE INTESTINE c.2515C>T p.R839W COSMIC PASSENGER/OTHER Possibly Damaging 219 TCGA-AA-3864-01 LARGE INTESTINE c.2389A>G p.T797A COSMIC PASSENGER/OTHER Possibly Damaging 220 TCGA-AA-3866-01 LARGE INTESTINE c.1855C>T p.R619W COSMIC PASSENGER/OTHER Benign 221 TCGA-AA-3941-01 LARGE INTESTINE c.1424C>A p.A475D COSMIC PASSENGER/OTHER Probably Damaging 222 TCGA-AA-3947-01 LARGE INTESTINE c.2560C>T p.H854Y COSMIC PASSENGER/OTHER Possibly Damaging 223 TCGA-AA-3984-01 LARGE INTESTINE c.144A>C p.K48N COSMIC PASSENGER/OTHER Probably Damaging 224 TCGA-AA-3984-01 LARGE INTESTINE c.497G>T p.R166I COSMIC PASSENGER/OTHER Possibly Damaging 225 TCGA-AA-A010-01 LARGE INTESTINE c.1644G>T p.G548G COSMIC NP NP 226 TCGA-AA-A010-01 LARGE INTESTINE c.2338G>T p.E780* COSMIC NP NP 227 TCGA-AA-A010-01 LARGE INTESTINE c.394G>T p.E132* COSMIC NP NP 228 TCGA-AA-A010-01 LARGE INTESTINE c.537G>T p.K179N COSMIC PASSENGER/OTHER Benign 229 TCGA-AA-A01R-01 LARGE INTESTINE c.1372G>T p.E458* COSMIC NP NP 230 TCGA-AB-2832-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2233G>A p.E745K COSMIC PASSENGER/OTHER Probably Damaging 231 TCGA-AB-2859-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1589G>A p.G530E COSMIC PASSENGER/OTHER Probably Damaging 232 TCGA-AB-3005-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2295A>T p.R765S COSMIC PASSENGER/OTHER Benign 233 TCGA-AD-5900-01 LARGE INTESTINE c.2664C>T p.Y888Y COSMIC NP NP 234 TCGA-AD-6889-01 LARGE INTESTINE c.2264G>A p.R755Q COSMIC PASSENGER/OTHER Benign 235 TCGA-AD-6901-01 LARGE INTESTINE c.2665G>A p.V889I COSMIC PASSENGER/OTHER Benign 236 TCGA-AF-2693-01 LARGE INTESTINE c.931T>C p.S311P COSMIC PASSENGER/OTHER Possibly Damaging 237 TCGA-AG-3727-01 LARGE INTESTINE c.1790C>G p.T597S COSMIC PASSENGER/OTHER Benign 238 TCGA-AG-3892-01 LARGE INTESTINE c.1011G>A p.R337R COSMIC NP NP 239 TCGA-AG-3892-01 LARGE INTESTINE c.1387T>G p.L463V COSMIC PASSENGER/OTHER Benign 240 TCGA-AG-3892-01 LARGE INTESTINE c.900C>A p.N300K COSMIC PASSENGER/OTHER Benign 241 TCGA-AG-A002-01 LARGE INTESTINE c.1365G>T p.E455D COSMIC PASSENGER/OTHER Possibly Damaging 242 TCGA-AG-A01L-01 LARGE INTESTINE c.1843C>T p.R615W COSMIC PASSENGER/OTHER Probably Damaging 243 TCGA-AG-A02N-01 LARGE INTESTINE c.58C>T p.R20W COSMIC PASSENGER/OTHER Benign 244 TCGA-AP-A051-01 ENDOMETRIUM c.1890C>T p.H630H COSMIC NP NP 245 TCGA-AP-A051-01 ENDOMETRIUM c.249C>T p.L83L COSMIC NP NP 246 TCGA-AP-A056-01 ENDOMETRIUM c.1344T>C p.N448N COSMIC NP NP 247 TCGA-AP-A056-01 ENDOMETRIUM c.1413G>T p.E471D COSMIC PASSENGER/OTHER Benign 248 TCGA-AP-A056-01 ENDOMETRIUM c.280G>T p.E94* COSMIC NP NP 249 TCGA-AP-A059-01 ENDOMETRIUM c.2273G>A p.R758H COSMIC PASSENGER/OTHER Possibly Damaging 250 TCGA-AP-A0L8-01 ENDOMETRIUM c.1781T>A p.V594D COSMIC PASSENGER/OTHER Benign 251 TCGA-AP-A0LF-01 ENDOMETRIUM c.1364A>G p.E455G COSMIC PASSENGER/OTHER Possibly Damaging 252 TCGA-AP-A0LM-01 ENDOMETRIUM c.394G>C p.E132Q COSMIC PASSENGER/OTHER Benign 253 TCGA-AX-A05Z-01 ENDOMETRIUM c.1222G>A p.E408K COSMIC PASSENGER/OTHER Benign 254 TCGA-AX-A05Z-01 ENDOMETRIUM c.171C>A p.N57K COSMIC PASSENGER/OTHER Probably Damaging 255 TCGA-AX-A1CP-01 ENDOMETRIUM c.366G>A p.A122A COSMIC NP NP 256 TCGA-AY-6196-01 LARGE INTESTINE c.2095C>T p.R699W COSMIC PASSENGER/OTHER Probably Damaging 257 TCGA-AZ-4315-01 LARGE INTESTINE c.929A>C p.K310T COSMIC PASSENGER/OTHER Benign 258 TCGA-B0-5699-01 KIDNEY c.569C>A p.A190E COSMIC PASSENGER/OTHER Benign 259 TCGA-B0-5702-01 KIDNEY c.2275G>A p.D759N COSMIC PASSENGER/OTHER Possibly Damaging 260 TCGA-B5-A0JY-01 ENDOMETRIUM c.1284G>T p.E428D COSMIC PASSENGER/OTHER Possibly Damaging 261 TCGA-B5-A0JY-01 ENDOMETRIUM c.1686C>A p.S562R COSMIC PASSENGER/OTHER Benign 262 TCGA-B5-A0JY-01 ENDOMETRIUM c.2516G>A p.R839Q COSMIC PASSENGER/OTHER Possibly Damaging 263 TCGA-B5-A0K4-01 ENDOMETRIUM c.2564C>A p.T855K COSMIC PASSENGER/OTHER Possibly Damaging 264 TCGA-B5-A0K7-01 ENDOMETRIUM c.2379T>A p.S793R COSMIC PASSENGER/OTHER Benign 265 TCGA-B5-A11E-01 ENDOMETRIUM c.1631G>T p.R544M COSMIC PASSENGER/OTHER Probably Damaging 266 TCGA-B5-A11E-01 ENDOMETRIUM c.2319G>T p.E773D COSMIC PASSENGER/OTHER Benign 267 TCGA-B5-A11E-01 ENDOMETRIUM c.506T>C p.L169P COSMIC PASSENGER/OTHER Benign 268 TCGA-B5-A11E-01 ENDOMETRIUM c.907G>T p.E303* COSMIC NP NP 269 TCGA-B5-A11N-01 ENDOMETRIUM c.1843C>T p.R615W COSMIC PASSENGER/OTHER Probably Damaging 270 TCGA-B5-A11N-01 ENDOMETRIUM c.721A>G p.S241G COSMIC PASSENGER/OTHER Possibly Damaging 271 TCGA-BG-A0M3-01 ENDOMETRIUM c.2379T>A p.S793R COSMIC PASSENGER/OTHER Benign 272 TCGA-BG-A0M9-01 ENDOMETRIUM c.2496T>C p.Y832Y COSMIC NP NP 273 TCGA-BG-A0MI-01 ENDOMETRIUM c.835C>T p.R279* COSMIC NP NP 274 TCGA-BG-A0YV-01 ENDOMETRIUM c.1389G>A p.L463L COSMIC NP NP 275 TCGA-BS-A0TC-01 ENDOMETRIUM c.836G>A p.R279Q COSMIC PASSENGER/OTHER Benign 276 TCGA-BS-A0U7-01 ENDOMETRIUM c.1030T>C p.C344R COSMIC PASSENGER/OTHER Probably Damaging 277 TCGA-BS-A0UF-01 ENDOMETRIUM c.272C>A p.S91Y COSMIC PASSENGER/OTHER Probably Damaging 278 TCGA-BS-A0UF-01 ENDOMETRIUM c.415T>G p.L139V COSMIC PASSENGER/OTHER Benign 279 TCGA-BS-A0UF-01 ENDOMETRIUM c.95C>A p.S32Y COSMIC PASSENGER/OTHER Probably Damaging 280 TCGA-BS-A0UV-01 ENDOMETRIUM c.1034G>A p.R345Q COSMIC PASSENGER/OTHER Possibly Damaging 281 TCGA-BS-A0V6-01 ENDOMETRIUM c.2358A>C p.R786S COSMIC PASSENGER/OTHER Benign 282 TCGA-BS-A0V8-01 ENDOMETRIUM c.752C>G p.S251* COSMIC NP NP 283 TCGA-BS-A0WQ-01 ENDOMETRIUM c.889A>T p.K297* COSMIC NP NP 284 TCGA-BT-A20R-01 URINARY TRACT c.494C>G p.S165* COSMIC NP NP 285 TCGA-CA-6717-01 LARGE INTESTINE c.1340G>A p.R447H COSMIC PASSENGER/OTHER Possibly Damaging 286 TCGA-CA-6717-01 LARGE INTESTINE c.550C>T p.R184* COSMIC NP NP 287 TCGA-CA-6718-01 LARGE INTESTINE c.1075G>A p.D359N COSMIC PASSENGER/OTHER Probably Damaging 288 TCGA-CA-6718-01 LARGE INTESTINE c.2311A>G p.T771A COSMIC PASSENGER/OTHER Benign 289 TCGA-CH-5748-01 PROSTATE c.1790C>G p.T597S COSMIC PASSENGER/OTHER Benign 290 TCGA-CI-6624-01 LARGE INTESTINE c.2436C>G p.G812G COSMIC NP NP 291 TCGA-CK-5912-01 LARGE INTESTINE c.1125A>T p.K375N COSMIC PASSENGER/OTHER Possibly Damaging 292 TCGA-CK-5913-01 LARGE INTESTINE c.2077G>C p.V693L COSMIC PASSENGER/OTHER Possibly Damaging 293 TCGA-CK-6746-01 LARGE INTESTINE c.1468G>T p.G490* COSMIC NP NP 294 TCGA-CL-5917-01 LARGE INTESTINE c.2358A>C p.R786S COSMIC PASSENGER/OTHER Benign 295 TCGA-CM-5341-01 LARGE INTESTINE c.638T>C p.I213T COSMIC PASSENGER/OTHER Benign 296 TCGA-D1-A103-01 ENDOMETRIUM c.1242G>A p.Q414Q COSMIC NP NP 297 TCGA-D1-A103-01 ENDOMETRIUM c.551G>A p.R184Q COSMIC PASSENGER/OTHER Probably Damaging 298 TCGA-D1-A103-01 ENDOMETRIUM c.909G>T p.E303D COSMIC PASSENGER/OTHER Probably Damaging 299 TCGA-D1-A103-01 ENDOMETRIUM c.914T>A p.V305E COSMIC PASSENGER/OTHER Benign 300 TCGA-D1-A16Y-01 ENDOMETRIUM c.836G>A p.R279Q COSMIC PASSENGER/OTHER Benign 301 TCGA-D1-A17Q-01 ENDOMETRIUM c.1248C>A p.F416L COSMIC PASSENGER/OTHER Benign 302 TCGA-D1-A17Q-01 ENDOMETRIUM c.2235G>T p.E745D COSMIC PASSENGER/OTHER Probably Damaging 303 TCGA-D1-A17Q-01 ENDOMETRIUM c.553G>T p.E185* COSMIC NP NP 304 TCGA-D1-A17R-01 ENDOMETRIUM c.1758G>T p.G586G COSMIC NP NP 305 TCGA-D5-5539-01 LARGE INTESTINE c.1568A>G p.K523R COSMIC PASSENGER/OTHER Benign 306 TCGA-D5-6928-01 LARGE INTESTINE c.1402T>C p.W468R COSMIC PASSENGER/OTHER Benign 307 TCGA-DC-5869-01 LARGE INTESTINE c.2190C>A p.S730R COSMIC PASSENGER/OTHER Possibly Damaging 308 TCGA-DK-A1AC-01 URINARY TRACT c.627G>C p.Q209H COSMIC PASSENGER/OTHER Benign 309 TCGA-DK-A2I6-01 URINARY TRACT c.1488A>C p.E496D COSMIC PASSENGER/OTHER Probably Damaging 310 TCGA-DM-A28K-01 LARGE INTESTINE c.1315C>T p.Q439* COSMIC NP NP 311 TCGA-DS-A1OD-01 CERVIX c.1855C>T p.R619W COSMIC PASSENGER/OTHER Benign 312 TCGA-DY-A0XA-01 LARGE INTESTINE c.2479A>G p.T827A COSMIC PASSENGER/OTHER Benign 313 TCGA-EJ-7328-01 PROSTATE c.2496T>C p.Y832Y COSMIC NP NP 314 TCGA-EJ-7793-01 PROSTATE c.2496T>C p.Y832Y COSMIC NP NP 315 TCGA-EW-A1OY-01 BREAST c.2126C>G p.T709S COSMIC PASSENGER/OTHER Benign 316 TCGA-EW-A1PA-01 BREAST c.2075A>G p.Y692C COSMIC PASSENGER/OTHER Probably Damaging 317 TCGA-G2-A3IB-01 URINARY TRACT c.1886G>C p.R629T COSMIC PASSENGER/OTHER Benign 318 TCGA-G2-A3IE-01 URINARY TRACT c.1970G>C p.R657T COSMIC PASSENGER/OTHER Benign 319 TCGA-G4-6303-01 LARGE INTESTINE c.100T>C p.Y34H COSMIC PASSENGER/OTHER Probably Damaging 320 TCGA-G9-6362-01 PROSTATE c.1162C>T p.H388Y COSMIC PASSENGER/OTHER Benign 321 TCGA-G9-6362-01 PROSTATE c.1790C>G p.T597S COSMIC PASSENGER/OTHER Benign 322 TCGA-GV-A3QG-01 URINARY TRACT c.2496T>C p.Y832Y COSMIC NP NP 323 TCGA-GV-A3QI-01 URINARY TRACT c.2496T>C p.Y832Y COSMIC NP NP 324 TCGA-H4-A2HQ-01 URINARY TRACT c.1377G>A p.R459R COSMIC NP NP 325 cSCCP2 SKIN c.1453G>A p.G485R COSMIC PASSENGER/OTHER Benign 326 cSCCP6 SKIN c.850G>A p.E284K COSMIC PASSENGER/OTHER Benign 327 pfg016T STOMACH c.1713G>A p.Q571Q COSMIC NP NP 328 tumor_4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE c.199A>G p.R67G COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PF01352 KRAB 28 62 6.7e-07 PF09514 SSXRD 170 202 7e-13 PB003219 Pfam-B_3219 196 316 7.2e-14 PB002602 Pfam-B_2602 242 358 1.9e-07 PB013260 Pfam-B_13260 309 334 5e-05 PB003219 Pfam-B_3219 310 371 4e-05 PB010245 Pfam-B_10245 315 342 0.0008 PF13465 zf-H2C2_2 542 562 3.1e-05 PB008588 Pfam-B_8588 548 604 0.00039 PB011295 Pfam-B_11295 553 627 4.6e-05 PF13465 zf-H2C2_2 566 590 1.1e-06 PF13465 zf-H2C2_2 595 618 2.6e-07 PF13465 zf-H2C2_2 623 646 9.8e-07 PF13465 zf-H2C2_2 651 674 1.9e-06 PF13465 zf-H2C2_2 679 702 5e-07 PF13465 zf-H2C2_2 707 731 1.5e-07 PF13465 zf-H2C2_2 734 757 1.5e-07 PB011295 Pfam-B_11295 750 826 0.00051 PF13465 zf-H2C2_2 762 785 1.5e-07 PF13465 zf-H2C2_2 790 815 5.3e-08 PB011295 Pfam-B_11295 806 882 0.0004 PF13465 zf-H2C2_2 818 843 5.8e-08 PB008588 Pfam-B_8588 837 885 0.001 PF13465 zf-H2C2_2 846 870 4.2e-08 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRDM9 PRDM9 PRDM9 ENSP00000296682 Q9NQV7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NQV7 PRDM9 ENSP00000296682 PRDM9 Q9NQV7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRDM9 ENSP00000296682 609760 Q9NQV7 PA33721
