dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PHF8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 585208 LUNG c.2020A>T p.M674L COSMIC NP NP 2 587374 LARGE INTESTINE c.2937G>C p.L979F COSMIC NP NP 3 587376 LARGE INTESTINE c.2667A>C p.Q889H COSMIC NP NP 4 587398 LARGE INTESTINE c.2318G>A p.R773H COSMIC NP NP 5 8014741 PANCREAS c.2011G>C p.D671H COSMIC NP NP 6 HN_62532 UPPER AERODIGESTIVE TRACT c.2904C>T p.R968R COSMIC NP NP 7 HX17T LIVER c.508A>G p.M170V COSMIC NP NP 8 ICGC_0048 PANCREAS c.2011G>C p.D671H COSMIC NP NP 9 LUAD-B00859 LUNG c.873G>A p.M291I COSMIC NP NP 10 LUAD-D02085 LUNG c.1092T>G p.F364L COSMIC NP Probably Damaging 11 LUAD-RT-S01813 LUNG c.376C>A p.L126M COSMIC NP NP 12 PALIBN HAEMATOPOIETIC AND LYMPHOID TISSUE c.281G>C p.R94T COSMIC NP NP 13 TCGA-05-4405-01 LUNG c.2080C>A p.L694M COSMIC NP NP 14 TCGA-05-5428-01 LUNG c.1465G>A p.G489S COSMIC NP NP 15 TCGA-09-2044-01 OVARY c.1337A>G p.Q446R COSMIC NP NP 16 TCGA-13-0886-01 OVARY c.1231G>A p.E411K COSMIC NP NP 17 TCGA-24-0979-01 OVARY c.2358G>C p.W786C COSMIC NP NP 18 TCGA-24-2289-01 OVARY c.1732A>G p.T578A COSMIC NP NP 19 TCGA-29-2436-01 OVARY c.2949C>T p.R983R COSMIC NP NP 20 TCGA-34-5231-01 LUNG c.2071A>G p.I691V COSMIC NP NP 21 TCGA-34-5240-01 LUNG c.1246C>T p.H416Y COSMIC NP NP 22 TCGA-36-2548-01 OVARY c.2524C>A p.P842T COSMIC NP NP 23 TCGA-55-7570-01 LUNG c.2222C>G p.S741C COSMIC NP NP 24 TCGA-55-7910-01 LUNG c.2798C>T p.S933L COSMIC NP NP 25 TCGA-55-8089-01 LUNG c.664G>C p.E222Q COSMIC NP NP 26 TCGA-66-2782-01 LUNG c.160G>T p.E54* COSMIC NP NP 27 TCGA-78-7537-01 LUNG c.708C>T p.L236L COSMIC NP NP 28 TCGA-99-8028-01 LUNG c.384G>A p.L128L COSMIC NP NP 29 TCGA-A5-A0G5-01 ENDOMETRIUM c.1279G>A p.V427I COSMIC NP NP 30 TCGA-A5-A0GA-01 ENDOMETRIUM c.489C>A p.T163T COSMIC NP NP 31 TCGA-A6-6781-01 LARGE INTESTINE c.1666G>T p.D556Y COSMIC NP NP 32 TCGA-AA-3555-01 LARGE INTESTINE c.1279G>A p.V427I COSMIC NP NP 33 TCGA-AA-3696-01 LARGE INTESTINE c.1918C>T p.R640W COSMIC NP NP 34 TCGA-AA-3821-01 LARGE INTESTINE c.1126C>A p.L376M COSMIC NP NP 35 TCGA-AA-3821-01 LARGE INTESTINE c.620C>T p.P207L COSMIC NP NP 36 TCGA-AA-A00J-01 LARGE INTESTINE c.102T>C p.C34C COSMIC NP NP 37 TCGA-AA-A00N-01 LARGE INTESTINE c.2130C>T p.T710T COSMIC NP NP 38 TCGA-AG-3892-01 LARGE INTESTINE c.632G>A p.R211Q COSMIC NP NP 39 TCGA-AN-A0FJ-01 BREAST c.1834G>C p.D612H COSMIC NP NP 40 TCGA-AP-A051-01 ENDOMETRIUM c.1141G>C p.G381R COSMIC NP NP 41 TCGA-AP-A059-01 ENDOMETRIUM c.2700G>A p.L900L COSMIC NP NP 42 TCGA-AP-A0LD-01 ENDOMETRIUM c.809G>A p.R270H COSMIC NP NP 43 TCGA-AP-A0LO-01 ENDOMETRIUM c.489C>A p.T163T COSMIC NP NP 44 TCGA-AQ-A04L-01 BREAST c.1003_1004delTT p.L335fs*4 COSMIC NP NP 45 TCGA-AR-A24Q-01 BREAST c.1537G>A p.A513T COSMIC NP NP 46 TCGA-AY-5543-01 LARGE INTESTINE c.2357G>T p.W786L COSMIC NP NP 47 TCGA-B2-5641-01 KIDNEY c.428C>A p.T143N COSMIC PASSENGER/OTHER Benign 48 TCGA-B5-A0JN-01 ENDOMETRIUM c.489C>A p.T163T COSMIC NP NP 49 TCGA-B5-A0JY-01 ENDOMETRIUM c.2046T>C p.L682L COSMIC NP NP 50 TCGA-B5-A0JY-01 ENDOMETRIUM c.2845C>A p.L949I COSMIC PASSENGER/OTHER Benign 51 TCGA-B5-A0JY-01 ENDOMETRIUM c.3070C>A p.L1024M COSMIC NP NP 52 TCGA-B5-A0JY-01 ENDOMETRIUM c.325A>C p.N109H COSMIC NP NP 53 TCGA-B5-A11E-01 ENDOMETRIUM c.1029G>T p.Q343H COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-B5-A11E-01 ENDOMETRIUM c.2083C>T p.L695F COSMIC NP NP 55 TCGA-B5-A11G-01 ENDOMETRIUM c.525T>C p.F175F COSMIC NP NP 56 TCGA-B5-A11V-01 ENDOMETRIUM c.428C>T p.T143I COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-B6-A0RL-01 BREAST c.6C>T p.A2A COSMIC NP NP 58 TCGA-B8-4154-01 KIDNEY c.1708G>T p.A570S COSMIC NP NP 59 TCGA-BH-A0AW-01 BREAST c.57C>T p.F19F COSMIC NP NP 60 TCGA-BP-4998-01 KIDNEY c.267A>G p.R89R COSMIC NP NP 61 TCGA-BS-A0TG-01 ENDOMETRIUM c.489C>A p.T163T COSMIC NP NP 62 TCGA-BS-A0UF-01 ENDOMETRIUM c.1660G>T p.D554Y COSMIC NP NP 63 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1897A>G p.I633V COSMIC NP NP 64 TCGA-BS-A0UV-01 ENDOMETRIUM c.2365G>A p.E789K COSMIC NP NP 65 TCGA-C8-A1HK-01 BREAST c.1148G>A p.R383Q COSMIC NP NP 66 TCGA-CA-6717-01 LARGE INTESTINE c.196C>T p.R66C COSMIC NP NP 67 TCGA-D1-A0ZN-01 ENDOMETRIUM c.2593C>T p.R865W COSMIC NP NP 68 TCGA-D1-A103-01 ENDOMETRIUM c.1140C>T p.R380R COSMIC NP NP 69 TCGA-D1-A103-01 ENDOMETRIUM c.3070C>A p.L1024M COSMIC NP NP 70 TCGA-D1-A167-01 ENDOMETRIUM c.2992C>T p.R998C COSMIC NP NP 71 TCGA-D8-A145-01 BREAST c.1141G>A p.G381S COSMIC NP NP 72 TCGA-DI-A0WH-01 ENDOMETRIUM c.2090C>T p.A697V COSMIC NP NP 73 TCGA-DI-A0WH-01 ENDOMETRIUM c.941C>A p.P314H COSMIC NP NP 74 TCGA-DM-A0XF-01 LARGE INTESTINE c.1733C>T p.T578M COSMIC NP NP 75 TCGA-F4-6570-01 LARGE INTESTINE c.2108delG p.G703fs*126 COSMIC NP NP 76 TCGA-F4-6570-01 LARGE INTESTINE c.78C>T p.C26C COSMIC NP NP 77 TCGA-G2-A2EC-01 URINARY TRACT c.1260C>T p.I420I COSMIC NP NP 78 TCGA-G2-A3IE-01 URINARY TRACT c.196C>T p.R66C COSMIC NP NP 79 TCGA-G4-6588-01 LARGE INTESTINE c.2318G>A p.R773H COSMIC NP NP 80 TCGA-GI-A2C8-01 BREAST c.2746A>T p.T916S COSMIC NP NP 81 TCGA-HC-7231-01 PROSTATE c.988T>G p.F330V COSMIC NP NP 82 YULAPE SKIN c.922_923GG>AA p.G308K COSMIC NP NP 83 cSCCP4 SKIN c.2576C>T p.P859L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PHF8 PHF8 PHF8 ENSP00000319473 Q9UPP1 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UPP1 PHF8 ENSP00000319473 PHF8 Q9UPP1 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PHF8 ENSP00000319473 300560 Q9UPP1 PA134889361
