dbEM

Protein: MINA

Mutation Data (+)

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587234	LARGE INTESTINE	c.859C>T	p.R287W	COSMIC	PASSENGER/OTHER	Probably Damaging
2	ESO-0129	OESOPHAGUS	c.406C>T	p.Q136*	COSMIC	NP	NP
3	ESO-1059	OESOPHAGUS	c.1018C>T	p.P340S	COSMIC	PASSENGER/OTHER	Probably Damaging
4	LUAD-RT-S01699	LUNG	c.29G>T	p.S10I	COSMIC	PASSENGER/OTHER	Benign
5	LUAD-S01315	LUNG	c.1365C>T	p.L455L	COSMIC	NP	NP
6	NB07C	AUTONOMIC GANGLIA	c.369G>T	p.Q123H	COSMIC	PASSENGER/OTHER	Benign
7	PD4112a	BREAST	c.523G>C	p.G175R	COSMIC	PASSENGER/OTHER	Probably Damaging
8	S00501	LUNG	c.535delC	p.H179fs*48	COSMIC	NP	NP
9	TCGA-13-0724-01	OVARY	c.1019C>G	p.P340R	COSMIC	PASSENGER/OTHER	Probably Damaging
10	TCGA-33-4566-01	LUNG	c.642G>A	p.E214E	COSMIC	NP	NP
11	TCGA-34-2600-01	LUNG	c.627C>G	p.Y209*	COSMIC	NP	NP
12	TCGA-44-7670-01	LUNG	c.271A>T	p.S91C	COSMIC	PASSENGER/OTHER	Probably Damaging
13	TCGA-46-3768-01	LUNG	c.1362C>A	p.S454S	COSMIC	NP	NP
14	TCGA-55-1594-01	LUNG	c.866G>A	p.G289D	COSMIC	PASSENGER/OTHER	Probably Damaging
15	TCGA-55-5899-01	LUNG	c.243C>T	p.F81F	COSMIC	NP	NP
16	TCGA-97-7554-01	LUNG	c.86G>T	p.G29V	COSMIC	PASSENGER/OTHER	Benign
17	TCGA-A5-A0GI-01	ENDOMETRIUM	c.849C>T	p.D283D	COSMIC	NP	NP
18	TCGA-A8-A08F-01	BREAST	c.1373_1390del18	p.E458_V463delECLIQV	COSMIC	NP	NP
19	TCGA-AA-3496-01	LARGE INTESTINE	c.549C>T	p.V183V	COSMIC	NP	NP
20	TCGA-AA-A010-01	LARGE INTESTINE	c.1164G>T	p.K388N	COSMIC	NP	NP
21	TCGA-AN-A0XO-01	BREAST	c.1153G>A	p.A385T	COSMIC	NP	NP
22	TCGA-AP-A051-01	ENDOMETRIUM	c.61C>T	p.Q21*	COSMIC	NP	NP
23	TCGA-AP-A056-01	ENDOMETRIUM	c.1393T>C	p.*465Q	COSMIC	NP	NP
24	TCGA-AP-A059-01	ENDOMETRIUM	c.141G>A	p.S47S	COSMIC	NP	NP
25	TCGA-AX-A0J1-01	ENDOMETRIUM	c.346G>T	p.D116Y	COSMIC	PASSENGER/OTHER	Possibly Damaging
26	TCGA-B6-A0X1-01	BREAST	c.631G>C	p.V211L	COSMIC	PASSENGER/OTHER	Benign
27	TCGA-BS-A0UF-01	ENDOMETRIUM	c.379G>T	p.D127Y	COSMIC	PASSENGER/OTHER	Possibly Damaging
28	TCGA-BS-A0UV-01	ENDOMETRIUM	c.379G>T	p.D127Y	COSMIC	PASSENGER/OTHER	Possibly Damaging
29	TCGA-CK-5912-01	LARGE INTESTINE	c.1020T>C	p.P340P	COSMIC	NP	NP
30	TCGA-CM-6674-01	LARGE INTESTINE	c.1235_1236delAG	p.E412fs*20	COSMIC	NP	NP
31	TCGA-CM-6674-01	LARGE INTESTINE	c.809A>G	p.D270G	COSMIC	PASSENGER/OTHER	Probably Damaging
32	TCGA-D1-A101-01	ENDOMETRIUM	c.212C>A	p.P71H	COSMIC	PASSENGER/OTHER	Benign
33	TCGA-D1-A103-01	ENDOMETRIUM	c.402G>A	p.T134T	COSMIC	NP	NP
34	TCGA-D1-A16Y-01	ENDOMETRIUM	c.1354G>A	p.V452I	COSMIC	NP	NP
35	TCGA-DK-A1AC-01	URINARY TRACT	c.1025C>T	p.S342F	COSMIC	NP	NP
36	YUDEDE	SKIN	c.850G>C	p.V284L	COSMIC	PASSENGER/OTHER	Benign
37	pfg008T	STOMACH	c.857T>C	p.L286S	COSMIC	PASSENGER/OTHER	Probably Damaging

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for MINA!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test
Tertiary structure (+)

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Users can also download Java from here.

Modelled Structure Structures available in PDB

2XDV, 4BU2, 4BXF,
Structure Domains (+)

1. PFAM Domains:

Domain ID Domain Name Start Site End Site E-value
PF08007 Cupin_4 52 363 3.2e-99

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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Users can also download Java from here.

1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo"

"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"

S. No. Position Amino acid Type

"; } else{echo"
Post translational modifications are not found!!

";} ?>

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
MINA	MINA	MINA	ENSP00000328251	Q8IUF8
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q8IUF8	MINA	ENSP00000328251	MINA	Q8IUF8
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
MINA	ENSP00000328251	612049	Q8IUF8	PA134991047

Modelled Structure	Structures available in PDB
	2XDV, 4BU2, 4BXF,

Domain ID	Domain Name	Start Site	End Site	E-value
PF08007	Cupin_4	52	363	3.2e-99

dbEM

Protein: MINA

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)