dbEM

Protein: KMT2B

Expand All | Collapse All

Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted
Copy number variation and expression profile (+)

Expression and CNV data is not present for KMT2B!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!
Tertiary structure (+)

Users must enabled the Java in their browser to see structure.
Users can also download Java from here.

Modelled Structure Structures available in PDB

3UVM, 4ERZ, 4PZI,

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PB004963	Pfam-B_4963	323	394	1.6e-06
PB002901	Pfam-B_2901	358	466	0.00082
PB011202	Pfam-B_11202	859	885	1.7e-08
PF02008	zf-CXXC	960	1005	5.1e-12
PB003525	Pfam-B_3525	1167	1219	4.5e-09
PB003418	Pfam-B_3418	1170	1245	4.5e-11
PB004447	Pfam-B_4447	1243	1333	1.5e-28
PF00628	PHD	1251	1302	3.6e-08
PF00628	PHD	1337	1394	2.2e-08
PB006332	Pfam-B_6332	1398	1479	9.8e-29
PF13771	zf-HC5HC2H	1608	1686	2e-15
PF05964	FYRN	1732	1782	2.1e-17
PF05965	FYRC	2412	2494	2.1e-23
PF00856	SET	2586	2690	1.6e-24

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0041233	2562	2715	7.59e-47
0050474	1237	1308	1.20e-10
0050474	1334	1405	3.77e-09
0037717	1200	1251	3.99e-04

Sequence Alignment (+)

Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.

1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo"

"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"

S. No. Position Amino acid Type

"; } else{echo"
Post translational modifications are not found!!

";} ?>

Other Databases Link (+)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
KMT2B	KMT2B	KMT2B	ENSP00000398837	Q9UMN6
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9UMN6	KMT2B	ENSP00000398837	KMT2B	Q9UMN6
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
KMT2B	ENSP00000398837	606834	Q9UMN6	NA

Raghava's Group