dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KDM6B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1653408 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4432T>G p.C1478G COSMIC PASSENGER/OTHER Probably Damaging 2 2000756 NS c.1417T>C p.C473R COSMIC PASSENGER/OTHER Benign 3 266395 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4432T>G p.C1478G COSMIC PASSENGER/OTHER Probably Damaging 4 587224 LARGE INTESTINE c.1756C>T p.R586W COSMIC PASSENGER/OTHER Probably Damaging 5 587226 LARGE INTESTINE c.2059G>A p.E687K COSMIC PASSENGER/OTHER Probably Damaging 6 587232 LARGE INTESTINE c.355T>C p.S119P COSMIC PASSENGER/OTHER Probably Damaging 7 587234 LARGE INTESTINE c.4186T>G p.F1396V COSMIC PASSENGER/OTHER Possibly Damaging 8 BN34T LIVER c.752_753insACCACC p.P264_L265insPP COSMIC NP NP 9 ESO-0025 OESOPHAGUS c.985C>T p.L329L COSMIC NP NP 10 HCC2998 LARGE INTESTINE c.643T>G p.S215A COSMIC PASSENGER/OTHER Benign 11 HCC81T LIVER c.723C>T p.P241P COSMIC NP NP 12 HCT-15 LARGE INTESTINE c.1033G>A p.E345K COSMIC PASSENGER/OTHER Probably Damaging 13 HCT-15 LARGE INTESTINE c.2446T>G p.Y816D COSMIC PASSENGER/OTHER Benign 14 LAU50_1 SKIN c.3409C>A p.H1137N COSMIC CANCER Benign 15 LAU50_2 SKIN c.3409C>A p.H1137N COSMIC CANCER Benign 16 LC_S12 LUNG c.1336C>T p.R446W COSMIC PASSENGER/OTHER Probably Damaging 17 LC_S15 LUNG c.275C>G p.S92C COSMIC PASSENGER/OTHER Probably Damaging 18 LUAD-CHTN-MAD06-00668 LUNG c.2010C>G p.L670L COSMIC NP NP 19 LUAD-F00121 LUNG c.577G>A p.G193R COSMIC PASSENGER/OTHER Possibly Damaging 20 LUAD-YINHD LUNG c.803T>A p.L268Q COSMIC PASSENGER/OTHER Probably Damaging 21 MB129PT CENTRAL NERVOUS SYSTEM c.3466C>T p.R1156* COSMIC NP NP 22 ME044T SKIN c.4819C>T p.R1607W COSMIC CANCER Possibly Damaging 23 ME045T SKIN c.3530C>T p.P1177L COSMIC CANCER Benign 24 MHH-CALL-2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1231C>T p.R411W COSMIC PASSENGER/OTHER Probably Damaging 25 PAKHZT HAEMATOPOIETIC AND LYMPHOID TISSUE c.1297T>C p.S433P COSMIC PASSENGER/OTHER Benign 26 Pa29C PANCREAS c.3195G>A p.P1065P COSMIC NP NP 27 TCGA-18-3409-01 LUNG c.650C>T p.P217L COSMIC CANCER Benign 28 TCGA-24-2289-01 OVARY c.3828C>T p.T1276T COSMIC NP NP 29 TCGA-33-4538-01 LUNG c.1408C>G p.P470A COSMIC PASSENGER/OTHER Benign 30 TCGA-35-5375-01 LUNG c.2881G>A p.E961K COSMIC PASSENGER/OTHER Possibly Damaging 31 TCGA-35-5375-01 LUNG c.2982G>C p.V994V COSMIC NP NP 32 TCGA-35-5375-01 LUNG c.3078G>A p.E1026E COSMIC NP NP 33 TCGA-35-5375-01 LUNG c.3309G>C p.L1103L COSMIC NP NP 34 TCGA-35-5375-01 LUNG c.3498G>A p.V1166V COSMIC NP NP 35 TCGA-35-5375-01 LUNG c.3507G>T p.K1169N COSMIC CANCER Benign 36 TCGA-35-5375-01 LUNG c.3520G>C p.E1174Q COSMIC CANCER Benign 37 TCGA-50-6590-01 LUNG c.410G>C p.G137A COSMIC PASSENGER/OTHER Benign 38 TCGA-50-7109-01 LUNG c.3761A>G p.D1254G COSMIC CANCER Benign 39 TCGA-55-7910-01 LUNG c.1231C>T p.R411W COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-63-5128-01 LUNG c.2776G>A p.E926K COSMIC CANCER Probably Damaging 41 TCGA-66-2756-01 LUNG c.686G>A p.R229Q COSMIC CANCER Probably Damaging 42 TCGA-66-2766-01 LUNG c.1941C>T p.G647G COSMIC NP NP 43 TCGA-66-2785-01 LUNG c.2194C>G p.L732V COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-78-7220-01 LUNG c.1603G>A p.V535M COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-85-6560-01 LUNG c.1196G>C p.S399T COSMIC PASSENGER/OTHER Benign 46 TCGA-A3-3380-01 KIDNEY c.2635G>T p.A879S COSMIC CANCER Benign 47 TCGA-A5-A0GX-01 ENDOMETRIUM c.752_753insACCACC p.P264_L265insPP COSMIC NP NP 48 TCGA-A5-A0R8-01 ENDOMETRIUM c.2253_2258delCACCAC p.T761_T762delTT COSMIC NP NP 49 TCGA-A5-A0VP-01 ENDOMETRIUM c.4384G>A p.V1462M COSMIC PASSENGER/OTHER Probably Damaging 50 TCGA-A6-5665-01 LARGE INTESTINE c.2016delT p.T676fs*24 COSMIC NP NP 51 TCGA-A6-6653-01 LARGE INTESTINE c.4301C>T p.T1434M COSMIC PASSENGER/OTHER Possibly Damaging 52 TCGA-A6-6780-01 LARGE INTESTINE c.74C>T p.A25V COSMIC PASSENGER/OTHER Possibly Damaging 53 TCGA-A6-6781-01 LARGE INTESTINE c.2154C>T p.G718G COSMIC NP NP 54 TCGA-AA-3492-01 LARGE INTESTINE c.2222delC p.T743fs*39 COSMIC NP NP 55 TCGA-AA-3713-01 LARGE INTESTINE c.2950C>T p.R984W COSMIC CANCER Probably Damaging 56 TCGA-AA-3811-01 LARGE INTESTINE c.3295delC p.K1101fs*3 COSMIC NP NP 57 TCGA-AA-3980-01 LARGE INTESTINE c.1955delC p.Q654fs*46 COSMIC NP NP 58 TCGA-AA-A02O-01 LARGE INTESTINE c.4522G>A p.V1508I COSMIC PASSENGER/OTHER Possibly Damaging 59 TCGA-AB-2885-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.881G>A p.R294H COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-AN-A0XT-01 BREAST c.753_761delACCACCACC p.P262_P264delPPP COSMIC NP NP 61 TCGA-AP-A051-01 ENDOMETRIUM c.96G>A p.P32P COSMIC NP NP 62 TCGA-AP-A059-01 ENDOMETRIUM c.3999C>A p.D1333E COSMIC CANCER Probably Damaging 63 TCGA-AP-A059-01 ENDOMETRIUM c.978C>T p.G326G COSMIC NP NP 64 TCGA-AP-A0LM-01 ENDOMETRIUM c.1245G>A p.P415P COSMIC NP NP 65 TCGA-AP-A0LM-01 ENDOMETRIUM c.4729G>A p.E1577K COSMIC PASSENGER/OTHER Benign 66 TCGA-AR-A0TX-01 BREAST c.4036G>A p.E1346K COSMIC CANCER Possibly Damaging 67 TCGA-AZ-6601-01 LARGE INTESTINE c.1259C>A p.P420H COSMIC PASSENGER/OTHER Possibly Damaging 68 TCGA-AZ-6601-01 LARGE INTESTINE c.3727G>A p.V1243M COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-B5-A0JY-01 ENDOMETRIUM c.3737G>A p.R1246H COSMIC CANCER Possibly Damaging 70 TCGA-B5-A11E-01 ENDOMETRIUM c.1587G>A p.P529P COSMIC NP NP 71 TCGA-B5-A11E-01 ENDOMETRIUM c.4055C>T p.A1352V COSMIC CANCER Benign 72 TCGA-B5-A11E-01 ENDOMETRIUM c.4695C>A p.G1565G COSMIC NP NP 73 TCGA-BI-A0VR-01 CERVIX c.2412C>G p.L804L COSMIC NP NP 74 TCGA-BK-A0C9-01 ENDOMETRIUM c.3503C>A p.P1168Q COSMIC CANCER Probably Damaging 75 TCGA-BP-5199-01 KIDNEY c.4667G>A p.R1556Q COSMIC PASSENGER/OTHER Benign 76 TCGA-C8-A12W-01 BREAST c.789A>C p.P263P COSMIC NP NP 77 TCGA-CA-6717-01 LARGE INTESTINE c.113G>A p.R38H COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-CF-A3MF-01 URINARY TRACT c.1410A>C p.P470P COSMIC NP NP 79 TCGA-CM-4743-01 LARGE INTESTINE c.4669G>A p.A1557T COSMIC PASSENGER/OTHER Possibly Damaging 80 TCGA-CM-6171-01 LARGE INTESTINE c.161C>A p.P54H COSMIC PASSENGER/OTHER Benign 81 TCGA-D1-A0ZU-01 ENDOMETRIUM c.753_761delACCACCACC p.P262_P264delPPP COSMIC NP NP 82 TCGA-D1-A17D-01 ENDOMETRIUM c.1383G>A p.L461L COSMIC NP NP 83 TCGA-D5-6540-01 LARGE INTESTINE c.3245C>T p.P1082L COSMIC PASSENGER/OTHER Benign 84 TCGA-D5-6927-01 LARGE INTESTINE c.1433G>A p.R478H COSMIC PASSENGER/OTHER Benign 85 TCGA-DK-A2I2-01 URINARY TRACT c.644C>T p.S215L COSMIC PASSENGER/OTHER Benign 86 TCGA-DM-A0X9-01 LARGE INTESTINE c.4858G>T p.E1620* COSMIC NP NP 87 TCGA-E2-A1IJ-01 BREAST c.2253_2255delCAC p.T762delT COSMIC NP NP 88 TCGA-EF-5830-01 LARGE INTESTINE c.312A>G p.P104P COSMIC NP NP 89 TCGA-G4-6586-01 LARGE INTESTINE c.1531delC p.R513fs*69 COSMIC NP NP 90 TCGA-G4-6588-01 LARGE INTESTINE c.1531delC p.R513fs*69 COSMIC NP NP 91 cSCCP7 SKIN c.2426_2427CC>TT p.S809F COSMIC CANCER Benign 92 tumor_4159170 HAEMATOPOIETIC AND LYMPHOID TISSUE c.117C>T p.S39S COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR KDM6B KDM6B KDM6B ENSP00000254846 O15054 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O15054 KDM6B ENSP00000254846 KDM6B O15054 Expression Atlas Protein Atlas OMIM IntAct PharmGKB KDM6B ENSP00000254846 611577 O15054 PA165431973
