dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KAT2B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334191 LUNG c.871G>T p.V291L COSMIC PASSENGER/OTHER Probably Damaging 2 2334202 LUNG c.1700G>C p.G567A COSMIC PASSENGER/OTHER Probably Damaging 3 36 OVARY c.409C>T p.R137W COSMIC PASSENGER/OTHER Probably Damaging 4 587400 LARGE INTESTINE c.1469G>A p.R490H COSMIC PASSENGER/OTHER Probably Damaging 5 BN13T LIVER c.2378A>T p.Q793L COSMIC PASSENGER/OTHER Benign 6 Br27P CENTRAL NERVOUS SYSTEM c.1387G>A p.D463N COSMIC PASSENGER/OTHER Possibly Damaging 7 CLL052 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1260A>G p.G420G COSMIC NP NP 8 ESO-085 OESOPHAGUS c.1730C>T p.T577I COSMIC PASSENGER/OTHER Probably Damaging 9 ESO-717 OESOPHAGUS c.2011delA p.K672fs*2 COSMIC NP NP 10 ESO-859 OESOPHAGUS c.1492G>A p.V498M COSMIC PASSENGER/OTHER Probably Damaging 11 LAU63 SKIN c.1774C>T p.H592Y COSMIC PASSENGER/OTHER Probably Damaging 12 LUAD-RT-S01702 LUNG c.2368G>A p.A790T COSMIC PASSENGER/OTHER Probably Damaging 13 P06-1125 PROSTATE c.1981G>A p.V661I COSMIC PASSENGER/OTHER Benign 14 PD4601a NS c.1651G>A p.D551N COSMIC PASSENGER/OTHER Benign 15 SNB75 CENTRAL NERVOUS SYSTEM c.212G>T p.G71V COSMIC PASSENGER/OTHER Benign 16 T-c KIDNEY c.2137C>A p.P713T COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-05-4244-01 LUNG c.1396G>A p.A466T COSMIC PASSENGER/OTHER Benign 18 TCGA-18-3409-01 LUNG c.1757G>T p.G586V COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-25-1627-01 OVARY c.457G>A p.V153M COSMIC PASSENGER/OTHER Possibly Damaging 20 TCGA-43-2578-01 LUNG c.544G>T p.D182Y COSMIC PASSENGER/OTHER Possibly Damaging 21 TCGA-43-6143-01 LUNG c.275A>G p.E92G COSMIC PASSENGER/OTHER Possibly Damaging 22 TCGA-44-6775-01 LUNG c.299G>A p.C100Y COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-55-6984-01 LUNG c.1060G>T p.E354* COSMIC NP NP 24 TCGA-56-5898-01 LUNG c.760C>T p.R254C COSMIC PASSENGER/OTHER Benign 25 TCGA-66-2773-01 LUNG c.2205C>T p.I735I COSMIC NP NP 26 TCGA-69-7764-01 LUNG c.568C>T p.L190L COSMIC NP NP 27 TCGA-69-7980-01 LUNG c.1188C>A p.Y396* COSMIC NP NP 28 TCGA-A5-A0VP-01 ENDOMETRIUM c.2381G>A p.R794Q COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-A6-6781-01 LARGE INTESTINE c.392G>A p.S131N COSMIC PASSENGER/OTHER Benign 30 TCGA-AA-3516-01 LARGE INTESTINE c.369C>T p.A123A COSMIC NP NP 31 TCGA-AA-3977-01 LARGE INTESTINE c.1102G>A p.D368N COSMIC PASSENGER/OTHER Benign 32 TCGA-AA-3977-01 LARGE INTESTINE c.1972G>A p.E658K COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-AA-3977-01 LARGE INTESTINE c.2045G>A p.R682Q COSMIC PASSENGER/OTHER Benign 34 TCGA-AA-A00N-01 LARGE INTESTINE c.1483G>T p.E495* COSMIC NP NP 35 TCGA-AA-A00N-01 LARGE INTESTINE c.1594G>T p.E532* COSMIC NP NP 36 TCGA-AA-A00N-01 LARGE INTESTINE c.1873G>T p.E625* COSMIC NP NP 37 TCGA-AB-3008-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1368G>A p.E456E COSMIC NP NP 38 TCGA-AF-6136-01 LARGE INTESTINE c.1388A>G p.D463G COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-AG-A002-01 LARGE INTESTINE c.2044C>T p.R682* COSMIC NP NP 40 TCGA-AG-A002-01 LARGE INTESTINE c.2261G>T p.R754I COSMIC PASSENGER/OTHER Possibly Damaging 41 TCGA-AP-A056-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC PASSENGER/OTHER Benign 42 TCGA-AP-A059-01 ENDOMETRIUM c.871G>A p.V291M COSMIC PASSENGER/OTHER Probably Damaging 43 TCGA-AP-A0LM-01 ENDOMETRIUM c.938G>A p.R313H COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-AX-A0J0-01 ENDOMETRIUM c.1331G>A p.R444Q COSMIC PASSENGER/OTHER Possibly Damaging 45 TCGA-AX-A0J0-01 ENDOMETRIUM c.718G>T p.E240* COSMIC NP NP 46 TCGA-AZ-6601-01 LARGE INTESTINE c.1560C>T p.N520N COSMIC NP NP 47 TCGA-B2-5641-01 KIDNEY c.313T>C p.S105P COSMIC PASSENGER/OTHER Benign 48 TCGA-B5-A11E-01 ENDOMETRIUM c.1594G>T p.E532* COSMIC NP NP 49 TCGA-BH-A0HP-01 BREAST c.1155C>A p.I385I COSMIC NP NP 50 TCGA-BP-4782-01 KIDNEY c.991A>G p.K331E COSMIC PASSENGER/OTHER Probably Damaging 51 TCGA-BP-4971-01 KIDNEY c.1029C>T p.L343L COSMIC NP NP 52 TCGA-BT-A0YX-01 URINARY TRACT c.256C>G p.P86A COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-CA-5254-01 LARGE INTESTINE c.1560C>A p.N520K COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-CK-5916-01 LARGE INTESTINE c.1907A>T p.Y636F COSMIC PASSENGER/OTHER Possibly Damaging 55 TCGA-CM-6163-01 LARGE INTESTINE c.331_332insG p.K112fs*4 COSMIC NP NP 56 TCGA-CM-6171-01 LARGE INTESTINE c.1525A>G p.K509E COSMIC PASSENGER/OTHER Possibly Damaging 57 TCGA-D1-A16Y-01 ENDOMETRIUM c.636G>T p.K212N COSMIC PASSENGER/OTHER Possibly Damaging 58 TCGA-D1-A174-01 ENDOMETRIUM c.1469G>A p.R490H COSMIC PASSENGER/OTHER Probably Damaging 59 TCGA-D1-A17Q-01 ENDOMETRIUM c.2027G>T p.R676I COSMIC PASSENGER/OTHER Possibly Damaging 60 TCGA-D8-A1X6-01 BREAST c.1607G>A p.R536Q COSMIC PASSENGER/OTHER Possibly Damaging 61 TCGA-DM-A28H-01 LARGE INTESTINE c.458T>C p.V153A COSMIC PASSENGER/OTHER Benign 62 TCGA-E2-A10C-01 BREAST c.1536G>T p.L512L COSMIC NP NP 63 TCGA-G4-6304-01 LARGE INTESTINE c.458T>C p.V153A COSMIC PASSENGER/OTHER Benign 64 TCGA-G4-6588-01 LARGE INTESTINE c.1425G>A p.L475L COSMIC NP NP 65 cSCCP1 SKIN c.1853A>G p.K618R COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
