dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: JMJD1C |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1781 NS c.6860T>C p.V2287A COSMIC NP NP 2 585208 LUNG c.4083G>T p.K1361N COSMIC NP NP 3 585258 LUNG c.4471C>G p.Q1491E COSMIC NP NP 4 587220 LARGE INTESTINE c.5912C>T p.A1971V COSMIC NP NP 5 587222 LARGE INTESTINE c.3976A>C p.N1326H COSMIC NP NP 6 587262 LARGE INTESTINE c.3761T>G p.F1254C COSMIC NP NP 7 587284 LARGE INTESTINE c.4483T>C p.S1495P COSMIC NP NP 8 587338 LARGE INTESTINE c.6214C>T p.R2072C COSMIC NP NP 9 587376 LARGE INTESTINE c.4993G>T p.E1665* COSMIC NP NP 10 BN26T LIVER c.5571_5572insCAATG p.G1858fs*20 COSMIC NP NP 11 CRC-3 LARGE INTESTINE c.6784C>A p.L2262I COSMIC NP NP 12 ESO-2472 OESOPHAGUS c.964G>C p.V322L COSMIC NP NP 13 ESO-717 OESOPHAGUS c.127C>T p.R43C COSMIC PASSENGER/OTHER Probably Damaging 14 ESOSCC156T OESOPHAGUS c.6329T>G p.V2110G COSMIC NP NP 15 GC8_T STOMACH c.2816_2821delGTTTAG p.G939_L940delGL COSMIC NP NP 16 GC8_T STOMACH c.722T>C p.M241T COSMIC NP Probably Damaging 17 GC8_T STOMACH c.890C>G p.T297S COSMIC NP NP 18 HCC1008 BREAST c.2731G>A p.A911T COSMIC NP NP 19 HCC1T LIVER c.1000T>G p.F334V COSMIC NP NP 20 HCC31T LIVER c.5990A>T p.N1997I COSMIC NP NP 21 HCC61T LIVER c.4178A>C p.K1393T COSMIC NP NP 22 HCC72T LIVER c.4415A>G p.N1472S COSMIC NP NP 23 HCT-15 LARGE INTESTINE c.2206A>G p.K736E COSMIC NP NP 24 HN_62421 UPPER AERODIGESTIVE TRACT c.2350C>T p.Q784* COSMIC NP NP 25 HN_62672 UPPER AERODIGESTIVE TRACT c.4444G>A p.D1482N COSMIC NP NP 26 HN_63021 UPPER AERODIGESTIVE TRACT c.9T>C p.V3V COSMIC NP NP 27 HX15T LIVER c.686delA p.K229fs*13 COSMIC NP NP 28 LC_C6 LUNG c.5376A>C p.E1792D COSMIC NP NP 29 LPJ108 HAEMATOPOIETIC AND LYMPHOID TISSUE c.299G>A p.S100N COSMIC NP NP 30 LPJ108 HAEMATOPOIETIC AND LYMPHOID TISSUE c.308C>G p.P103R COSMIC NP NP 31 LPJ108 HAEMATOPOIETIC AND LYMPHOID TISSUE c.345T>G p.Y115* COSMIC NP NP 32 LPJ108 HAEMATOPOIETIC AND LYMPHOID TISSUE c.349T>G p.S117A COSMIC NP NP 33 LUAD-B02594 LUNG c.1116G>T p.M372I COSMIC NP NP 34 LUAD-NYU201 LUNG c.2441C>T p.A814V COSMIC NP NP 35 LUAD-RT-S01840 LUNG c.129C>A p.R43R COSMIC NP NP 36 LUAD-S01315 LUNG c.4774G>A p.D1592N COSMIC NP NP 37 LUAD-S01478 LUNG c.2173C>G p.P725A COSMIC NP NP 38 LUAD_E01147 LUNG c.3801G>T p.K1267N COSMIC NP NP 39 MB106X CENTRAL NERVOUS SYSTEM c.125G>A p.R42Q COSMIC NP NP 40 MD-324 CENTRAL NERVOUS SYSTEM c.2830A>G p.I944V COSMIC NP NP 41 ME009T SKIN c.850C>T p.P284S COSMIC NP Probably Damaging 42 ME100L SKIN c.6705C>A p.H2235Q COSMIC NP NP 43 PA202 PANCREAS c.2816_2821delGTTTAG p.G939_L940delGL COSMIC NP NP 44 PR-09-5245 PROSTATE c.3647C>A p.S1216* COSMIC NP NP 45 RK082_C01 LIVER c.4765A>G p.I1589V COSMIC NP NP 46 RK148_C01 LIVER c.5678A>G p.N1893S COSMIC NP NP 47 SA085 BREAST c.859C>G p.P287A COSMIC PASSENGER/OTHER Possibly Damaging 48 SK-MEL-2 SKIN c.5308T>C p.S1770P COSMIC NP NP 49 SR HAEMATOPOIETIC AND LYMPHOID TISSUE c.2814_2819delAGGTTT p.G939_L940delGL COSMIC NP NP 50 T155 ENDOMETRIUM c.4292A>G p.Y1431C COSMIC NP NP 51 T94 PROSTATE c.6332A>T p.Y2111F COSMIC NP NP 52 TCGA-05-4397-01 LUNG c.2743C>A p.Q915K COSMIC NP NP 53 TCGA-09-2051-01 OVARY c.300C>T p.S100S COSMIC NP NP 54 TCGA-10-0937-01 OVARY c.5052G>A p.M1684I COSMIC NP NP 55 TCGA-22-5491-01 LUNG c.3326G>A p.R1109H COSMIC NP NP 56 TCGA-23-1110-01 OVARY c.6212T>A p.V2071E COSMIC NP NP 57 TCGA-24-1423-01 OVARY c.6584A>G p.N2195S COSMIC NP Probably Damaging 58 TCGA-25-2393-01 OVARY c.5563T>C p.Y1855H COSMIC NP NP 59 TCGA-34-5231-01 LUNG c.4517G>T p.G1506V COSMIC NP NP 60 TCGA-35-4123-01 LUNG c.5294C>T p.P1765L COSMIC NP NP 61 TCGA-35-5375-01 LUNG c.628A>T p.N210Y COSMIC NP NP 62 TCGA-39-5024-01 LUNG c.3004G>T p.E1002* COSMIC NP NP 63 TCGA-39-5024-01 LUNG c.3005A>T p.E1002V COSMIC NP NP 64 TCGA-44-6778-01 LUNG c.2104A>T p.S702C COSMIC NP NP 65 TCGA-44-7670-01 LUNG c.3418G>T p.V1140L COSMIC NP NP 66 TCGA-46-3769-01 LUNG c.6303A>G p.E2101E COSMIC NP NP 67 TCGA-49-4486-01 LUNG c.6198G>C p.L2066F COSMIC PASSENGER/OTHER Probably Damaging 68 TCGA-50-6590-01 LUNG c.2935C>A p.R979S COSMIC NP NP 69 TCGA-50-6593-01 LUNG c.3249G>T p.M1083I COSMIC NP NP 70 TCGA-55-6970-01 LUNG c.644G>A p.W215* COSMIC NP NP 71 TCGA-60-2698-01 LUNG c.3338G>C p.R1113T COSMIC NP NP 72 TCGA-60-2722-01 LUNG c.6171A>T p.E2057D COSMIC NP NP 73 TCGA-66-2763-01 LUNG c.139G>A p.A47T COSMIC NP NP 74 TCGA-66-2767-01 LUNG c.689G>A p.R230Q COSMIC NP NP 75 TCGA-73-4668-01 LUNG c.1478C>T p.T493I COSMIC NP NP 76 TCGA-75-6211-01 LUNG c.2559C>G p.R853R COSMIC NP NP 77 TCGA-78-7159-01 LUNG c.4795A>T p.T1599S COSMIC NP NP 78 TCGA-78-7166-01 LUNG c.3699C>T p.T1233T COSMIC NP NP 79 TCGA-91-6836-01 LUNG c.5550C>G p.A1850A COSMIC NP NP 80 TCGA-A3-3357-01 KIDNEY c.5006G>C p.W1669S COSMIC NP NP 81 TCGA-A3-3367-01 KIDNEY c.6569A>T p.Q2190L COSMIC PASSENGER/OTHER Benign 82 TCGA-A5-A0VP-01 ENDOMETRIUM c.2147C>T p.P716L COSMIC NP NP 83 TCGA-A5-A0VP-01 ENDOMETRIUM c.5912C>T p.A1971V COSMIC NP NP 84 TCGA-A6-6781-01 LARGE INTESTINE c.2477A>T p.E826V COSMIC NP NP 85 TCGA-AA-3510-01 LARGE INTESTINE c.2222G>T p.R741I COSMIC NP NP 86 TCGA-AA-3672-01 LARGE INTESTINE c.5189T>C p.M1730T COSMIC NP NP 87 TCGA-AA-3866-01 LARGE INTESTINE c.2419C>T p.L807F COSMIC NP NP 88 TCGA-AA-3949-01 LARGE INTESTINE c.2596C>A p.P866T COSMIC NP NP 89 TCGA-AA-3977-01 LARGE INTESTINE c.4043A>C p.K1348T COSMIC NP NP 90 TCGA-AA-3984-01 LARGE INTESTINE c.1254A>C p.K418N COSMIC NP Benign 91 TCGA-AA-A010-01 LARGE INTESTINE c.6411C>G p.D2137E COSMIC NP Benign 92 TCGA-AA-A01K-01 LARGE INTESTINE c.5759T>C p.I1920T COSMIC NP NP 93 TCGA-AB-2857-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3604T>C p.S1202P COSMIC NP NP 94 TCGA-AD-5900-01 LARGE INTESTINE c.5364delA p.E1789fs*45 COSMIC NP NP 95 TCGA-AG-3883-01 LARGE INTESTINE c.1717C>T p.H573Y COSMIC NP NP 96 TCGA-AP-A051-01 ENDOMETRIUM c.1848G>T p.Q616H COSMIC NP NP 97 TCGA-AP-A051-01 ENDOMETRIUM c.4547G>T p.R1516I COSMIC NP NP 98 TCGA-AP-A056-01 ENDOMETRIUM c.4299G>T p.K1433N COSMIC NP NP 99 TCGA-AP-A059-01 ENDOMETRIUM c.2528A>G p.H843R COSMIC PASSENGER/OTHER Possibly Damaging 100 TCGA-AP-A059-01 ENDOMETRIUM c.3703G>A p.A1235T COSMIC NP NP 101 TCGA-AP-A059-01 ENDOMETRIUM c.4890T>C p.C1630C COSMIC NP NP 102 TCGA-AP-A059-01 ENDOMETRIUM c.5520A>G p.L1840L COSMIC NP NP 103 TCGA-AP-A059-01 ENDOMETRIUM c.6119G>A p.R2040K COSMIC PASSENGER/OTHER Benign 104 TCGA-AP-A0LM-01 ENDOMETRIUM c.3109G>A p.E1037K COSMIC NP NP 105 TCGA-AP-A0LM-01 ENDOMETRIUM c.3999G>T p.K1333N COSMIC NP NP 106 TCGA-AP-A0LM-01 ENDOMETRIUM c.445C>T p.R149* COSMIC NP NP 107 TCGA-AP-A0LM-01 ENDOMETRIUM c.787G>A p.E263K COSMIC NP NP 108 TCGA-AX-A05Z-01 ENDOMETRIUM c.5737A>C p.N1913H COSMIC NP NP 109 TCGA-AX-A060-01 ENDOMETRIUM c.3716T>A p.L1239* COSMIC NP NP 110 TCGA-AX-A063-01 ENDOMETRIUM c.4729G>A p.E1577K COSMIC PASSENGER/OTHER Probably Damaging 111 TCGA-AX-A0J0-01 ENDOMETRIUM c.1418G>A p.R473Q COSMIC NP NP 112 TCGA-AX-A0J1-01 ENDOMETRIUM c.735G>A p.S245S COSMIC NP NP 113 TCGA-AY-6197-01 LARGE INTESTINE c.2342T>C p.V781A COSMIC NP NP 114 TCGA-AY-6197-01 LARGE INTESTINE c.5224C>A p.P1742T COSMIC NP NP 115 TCGA-AY-6386-01 LARGE INTESTINE c.2873C>A p.T958K COSMIC NP NP 116 TCGA-AZ-4315-01 LARGE INTESTINE c.892A>G p.N298D COSMIC NP NP 117 TCGA-AZ-6598-01 LARGE INTESTINE c.5364delA p.E1789fs*45 COSMIC NP NP 118 TCGA-B5-A0JY-01 ENDOMETRIUM c.1489G>A p.D497N COSMIC NP NP 119 TCGA-B5-A0JY-01 ENDOMETRIUM c.3457T>G p.F1153V COSMIC NP NP 120 TCGA-B5-A11E-01 ENDOMETRIUM c.6361C>A p.L2121I COSMIC NP Probably Damaging 121 TCGA-B6-A0RS-01 BREAST c.4156G>T p.D1386Y COSMIC NP NP 122 TCGA-BH-A18L-01 BREAST c.1189C>T p.R397* COSMIC NP NP 123 TCGA-BP-5176-01 KIDNEY c.5497C>T p.L1833L COSMIC NP NP 124 TCGA-BS-A0TA-01 ENDOMETRIUM c.612A>G p.G204G COSMIC NP NP 125 TCGA-BS-A0TC-01 ENDOMETRIUM c.151G>A p.V51I COSMIC NP NP 126 TCGA-BS-A0TE-01 ENDOMETRIUM c.1765T>G p.L589V COSMIC PASSENGER/OTHER Benign 127 TCGA-BS-A0UF-01 ENDOMETRIUM c.4446T>G p.D1482E COSMIC NP NP 128 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1956T>C p.H652H COSMIC NP NP 129 TCGA-CA-6717-01 LARGE INTESTINE c.4031A>C p.K1344T COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-CA-6717-01 LARGE INTESTINE c.4202G>T p.R1401I COSMIC NP NP 131 TCGA-CJ-4897-01 KIDNEY c.4882G>A p.D1628N COSMIC NP NP 132 TCGA-CJ-5677-01 KIDNEY c.5866G>A p.V1956M COSMIC NP NP 133 TCGA-CK-4947-01 LARGE INTESTINE c.5565T>C p.Y1855Y COSMIC NP NP 134 TCGA-CK-4952-01 LARGE INTESTINE c.6583A>G p.N2195D COSMIC NP NP 135 TCGA-CM-4744-01 LARGE INTESTINE c.6583A>G p.N2195D COSMIC NP NP 136 TCGA-CM-6169-01 LARGE INTESTINE c.6584A>G p.N2195S COSMIC NP Probably Damaging 137 TCGA-CM-6674-01 LARGE INTESTINE c.5357A>G p.E1786G COSMIC NP NP 138 TCGA-CM-6678-01 LARGE INTESTINE c.6584A>G p.N2195S COSMIC NP Probably Damaging 139 TCGA-CW-5581-01 KIDNEY c.2126C>G p.S709C COSMIC NP NP 140 TCGA-CZ-5458-01 KIDNEY c.5643A>G p.E1881E COSMIC NP NP 141 TCGA-D1-A103-01 ENDOMETRIUM c.5495T>C p.L1832S COSMIC NP NP 142 TCGA-D1-A103-01 ENDOMETRIUM c.591C>A p.P197P COSMIC NP NP 143 TCGA-D1-A16X-01 ENDOMETRIUM c.263G>T p.R88I COSMIC NP Possibly Damaging 144 TCGA-D1-A16X-01 ENDOMETRIUM c.361A>C p.N121H COSMIC NP NP 145 TCGA-D1-A16X-01 ENDOMETRIUM c.4031A>C p.K1344T COSMIC PASSENGER/OTHER Probably Damaging 146 TCGA-D1-A17Q-01 ENDOMETRIUM c.284G>A p.R95K COSMIC NP NP 147 TCGA-D1-A1NU-01 ENDOMETRIUM c.1035C>T p.S345S COSMIC NP NP 148 TCGA-D5-6538-01 LARGE INTESTINE c.6583A>G p.N2195D COSMIC NP NP 149 TCGA-D5-6538-01 LARGE INTESTINE c.6584A>G p.N2195S COSMIC NP Probably Damaging 150 TCGA-D5-6541-01 LARGE INTESTINE c.5050A>G p.M1684V COSMIC NP NP 151 TCGA-D5-6928-01 LARGE INTESTINE c.157G>A p.A53T COSMIC NP NP 152 TCGA-DI-A0WH-01 ENDOMETRIUM c.2477A>T p.E826V COSMIC NP NP 153 TCGA-DI-A0WH-01 ENDOMETRIUM c.3229G>A p.G1077R COSMIC NP NP 154 TCGA-DK-A1AC-01 URINARY TRACT c.3031C>A p.P1011T COSMIC NP Possibly Damaging 155 TCGA-DK-A1AC-01 URINARY TRACT c.781C>T p.P261S COSMIC NP NP 156 TCGA-DK-A3IQ-01 URINARY TRACT c.5374G>A p.E1792K COSMIC NP NP 157 TCGA-DK-A3IS-01 URINARY TRACT c.2419C>T p.L807F COSMIC NP NP 158 TCGA-DK-A3IS-01 URINARY TRACT c.2422C>T p.Q808* COSMIC NP NP 159 TCGA-DR-A0ZL-01 CERVIX c.6193C>T p.H2065Y COSMIC NP NP 160 TCGA-DY-A1DC-01 LARGE INTESTINE c.6583A>G p.N2195D COSMIC NP NP 161 TCGA-DY-A1DG-01 LARGE INTESTINE c.6583A>G p.N2195D COSMIC NP NP 162 TCGA-E2-A1IH-01 BREAST c.2371G>A p.E791K COSMIC NP NP 163 TCGA-E6-A1LZ-01 ENDOMETRIUM c.4920C>T p.V1640V COSMIC NP NP 164 TCGA-EJ-5526-01 PROSTATE c.6894G>C p.E2298D COSMIC NP NP 165 TCGA-EJ-7314-01 PROSTATE c.3585A>C p.S1195S COSMIC NP NP 166 TCGA-EO-A1Y8-01 ENDOMETRIUM c.4697G>T p.S1566I COSMIC NP NP 167 TCGA-G4-6293-01 LARGE INTESTINE c.5051T>C p.M1684T COSMIC NP NP 168 TCGA-G4-6323-01 LARGE INTESTINE c.6584A>G p.N2195S COSMIC NP Probably Damaging 169 WA38 PROSTATE c.4292A>G p.Y1431C COSMIC NP NP 170 cSCCP4 SKIN c.4835C>T p.A1612V COSMIC NP NP 171 cSCCP7 SKIN c.2000C>A p.P667Q COSMIC NP NP 172 ccRCC-32 KIDNEY c.1060G>C p.D354H COSMIC NP NP 173 ccRCC-9 KIDNEY c.934C>A p.L312I COSMIC NP NP 174 pfg008T STOMACH c.3694A>G p.S1232G COSMIC NP NP 175 pfg019T STOMACH c.5364delA p.E1789fs*45 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB002770 Pfam-B_2770 214 540 4.3e-63 PB017329 Pfam-B_17329 541 947 1.5e-263 PB016501 Pfam-B_16501 1879 1927 0.00021 PB019453 Pfam-B_19453 1929 2023 3.8e-59 PB014856 Pfam-B_14856 2090 2143 9.4e-29 PB015350 Pfam-B_15350 2153 2224 1.5e-37 PB016670 Pfam-B_16670 2273 2322 9.7e-21 PB016202 Pfam-B_16202 2325 2357 3.6e-11 PF02373 JmjC 2382 2481 1.3e-10 2. Superfamily Domains:Domain ID Start Site End Site E-value 0047105 2154 2348 2.03e-40 0053820 1844 1909 4.59e-04 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR JMJD1C JMJD1C JMJD1C ENSP00000382204 Q15652 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q15652 JMJD1C ENSP00000382204 JMJD1C Q15652 Expression Atlas Protein Atlas OMIM IntAct PharmGKB JMJD1C ENSP00000382204 604503 Q15652 PA128394767
