dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: JARID2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.3001G>C p.V1001L CCLE PASSENGER/OTHER Probably Damaging 2 769P KIDNEY c.304G>A p.E102K CCLE PASSENGER/OTHER Benign 3 BICR18 UPPER AERODIGESTIVE TRACT c.357G>A p.Q119Q CCLE NP NP 4 BICR18 UPPER AERODIGESTIVE TRACT c.468T>C p.D156D CCLE NP NP 5 BXPC3 PANCREAS c.718A>G p.K240E CCLE PASSENGER/OTHER Benign 6 DKMG CENTRAL NERVOUS SYSTEM c.3641C>G p.P1214R CCLE PASSENGER/OTHER Possibly Damaging 7 HCC1569 BREAST c.288T>C p.S96S CCLE NP NP 8 HCT15 LARGE INTESTINE c.2960C>T p.P987L CCLE PASSENGER/OTHER Probably Damaging 9 HEC1A ENDOMETRIUM c.3682G>A p.V1228M CCLE PASSENGER/OTHER Possibly Damaging 10 HEC1B ENDOMETRIUM c.3682G>A p.V1228M CCLE PASSENGER/OTHER Possibly Damaging 11 HRT18 LARGE INTESTINE c.2662C>T p.H888Y CCLE PASSENGER/OTHER Probably Damaging 12 JHUEM2 ENDOMETRIUM c.2996G>T p.R999M CCLE PASSENGER/OTHER Probably Damaging 13 LOVO LARGE INTESTINE c.3112A>C p.S1038R CCLE PASSENGER/OTHER Possibly Damaging 14 LS180 LARGE INTESTINE c.643A>C p.T215P CCLE PASSENGER/OTHER Benign 15 LS411N LARGE INTESTINE c.538C>A p.Q180K CCLE PASSENGER/OTHER Possibly Damaging 16 MDAMB435S SKIN c.114G>T p.K38N CCLE PASSENGER/OTHER Benign 17 MDAPCA2B PROSTATE c.255A>C p.A85A CCLE NP NP 18 MOLT13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.698G>A p.R233Q CCLE PASSENGER/OTHER Benign 19 MOLT16 HAEMATOPOIETIC AND LYMPHOID TISSUE c.79C>T p.R27W CCLE PASSENGER/OTHER Probably Damaging 20 NCIH647 LUNG c.2218C>T p.H740Y CCLE PASSENGER/OTHER Probably Damaging 21 NCIH660 PROSTATE c.269C>G p.S90C CCLE PASSENGER/OTHER Probably Damaging 22 NUGC3 STOMACH c.2806C>A p.P936T CCLE PASSENGER/OTHER Probably Damaging 23 OVK18 OVARY c.1817G>A p.R606Q CCLE PASSENGER/OTHER Possibly Damaging 24 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.3210_3210delA p.A1070fs CCLE NP NP 25 RKO LARGE INTESTINE c.3728C>A p.S1243* CCLE NP NP 26 RL HAEMATOPOIETIC AND LYMPHOID TISSUE c.982G>A p.V328I CCLE PASSENGER/OTHER Benign 27 SNGM ENDOMETRIUM c.2657C>T p.S886L CCLE PASSENGER/OTHER Probably Damaging 28 SNGM ENDOMETRIUM c.3010A>G p.S1004G CCLE PASSENGER/OTHER Possibly Damaging 29 SNU175 LARGE INTESTINE c.2479C>T p.R827* CCLE NP NP 30 SNU1 STOMACH c.1267G>T p.G423W CCLE PASSENGER/OTHER Possibly Damaging 31 SNU81 LARGE INTESTINE c.490C>T p.R164* CCLE NP NP 32 SNUC2A LARGE INTESTINE c.572A>G p.E191G CCLE PASSENGER/OTHER Benign 33 SNUC5 LARGE INTESTINE c.560A>C p.E187A CCLE PASSENGER/OTHER Possibly Damaging 34 SUDHL5 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3661C>T p.R1221C CCLE PASSENGER/OTHER Probably Damaging 35 SW1116 LARGE INTESTINE c.466G>A p.D156N CCLE PASSENGER/OTHER Probably Damaging 36 SW48 LARGE INTESTINE c.1770_1770delC p.I590fs CCLE NP NP 37 SW48 LARGE INTESTINE c.231G>T p.Q77H CCLE PASSENGER/OTHER Benign 38 SW48 LARGE INTESTINE c.2674C>A p.L892I CCLE PASSENGER/OTHER Probably Damaging 39 UMUC3 URINARY TRACT c.782G>C p.R261P CCLE PASSENGER/OTHER Probably Damaging 40 1946219 LUNG c.1649G>T p.G550V COSMIC PASSENGER/OTHER Probably Damaging 41 585208 LUNG c.2166G>T p.E722D COSMIC PASSENGER/OTHER Benign 42 587220 LARGE INTESTINE c.1523C>T p.T508M COSMIC PASSENGER/OTHER Benign 43 587226 LARGE INTESTINE c.2258G>A p.R753H COSMIC PASSENGER/OTHER Probably Damaging 44 587228 LARGE INTESTINE c.1160G>A p.R387H COSMIC PASSENGER/OTHER Probably Damaging 45 587234 LARGE INTESTINE c.2197C>T p.R733C COSMIC PASSENGER/OTHER Probably Damaging 46 587342 LARGE INTESTINE c.1412G>A p.G471D COSMIC PASSENGER/OTHER Benign 47 587376 LARGE INTESTINE c.146C>T p.A49V COSMIC PASSENGER/OTHER Benign 48 587376 LARGE INTESTINE c.497C>A p.S166Y COSMIC PASSENGER/OTHER Probably Damaging 49 ESO-017 OESOPHAGUS c.880C>T p.R294W COSMIC PASSENGER/OTHER Probably Damaging 50 ESO-0292 OESOPHAGUS c.1266delG p.R425fs*36 COSMIC NP NP 51 ESO-1670 OESOPHAGUS c.3364G>A p.G1122R COSMIC PASSENGER/OTHER Possibly Damaging 52 ESO-2143 OESOPHAGUS c.1456A>T p.K486* COSMIC NP NP 53 ESO-721 OESOPHAGUS c.3622G>A p.E1208K COSMIC PASSENGER/OTHER Possibly Damaging 54 ESO-859 OESOPHAGUS c.1266delG p.R425fs*36 COSMIC NP NP 55 ESO-859 OESOPHAGUS c.2719G>A p.G907S COSMIC PASSENGER/OTHER Probably Damaging 56 ESO-859 OESOPHAGUS c.3704C>T p.A1235V COSMIC PASSENGER/OTHER Benign 57 GC6_T STOMACH c.3205G>A p.E1069K COSMIC PASSENGER/OTHER Possibly Damaging 58 HCT-15 LARGE INTESTINE c.1577C>G p.S526C COSMIC PASSENGER/OTHER Probably Damaging 59 HCT-15 LARGE INTESTINE c.2960C>T p.P987L COSMIC PASSENGER/OTHER Probably Damaging 60 HF-23896 LUNG c.1649G>T p.G550V COSMIC PASSENGER/OTHER Probably Damaging 61 ID46 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3005_3006insG p.Q1003fs*25 COSMIC NP NP 62 LUAD-D01603 LUNG c.2263G>T p.E755* COSMIC NP NP 63 LUAD-F00089 LUNG c.815C>T p.A272V COSMIC PASSENGER/OTHER Benign 64 LUAD-NYU284 LUNG c.209G>T p.G70V COSMIC PASSENGER/OTHER Benign 65 LUAD-S01302 LUNG c.3249C>G p.A1083A COSMIC NP NP 66 LUAD-S01315 LUNG c.2543A>G p.Q848R COSMIC PASSENGER/OTHER Probably Damaging 67 LXFL529 LUNG c.1364C>T p.S455L COSMIC PASSENGER/OTHER Benign 68 M14 HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 69 MD-253 CENTRAL NERVOUS SYSTEM c.581A>T p.D194V COSMIC PASSENGER/OTHER Probably Damaging 70 MDA-MB-435 HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 71 MDA-N HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 72 MZ1-PC PANCREAS c.2596G>A p.G866S COSMIC PASSENGER/OTHER Probably Damaging 73 NB07C AUTONOMIC GANGLIA c.246G>T p.K82N COSMIC PASSENGER/OTHER Possibly Damaging 74 NCI-H2126 LUNG c.1617G>A p.S539S COSMIC NP NP 75 RK115_C01 LIVER c.2275G>T p.G759W COSMIC PASSENGER/OTHER Probably Damaging 76 SA069 BREAST c.1858C>T p.R620C COSMIC PASSENGER/OTHER Benign 77 T95 PROSTATE c.651delA p.K217fs*90 COSMIC NP NP 78 TCGA-13-0793-01 OVARY c.1670T>G p.I557S COSMIC PASSENGER/OTHER Benign 79 TCGA-13-0897-01 OVARY c.733G>T p.E245* COSMIC NP NP 80 TCGA-18-3409-01 LUNG c.1179C>T p.L393L COSMIC NP NP 81 TCGA-22-5491-01 LUNG c.2078G>A p.R693Q COSMIC PASSENGER/OTHER Probably Damaging 82 TCGA-25-1326-01 OVARY c.2957C>A p.S986Y COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-34-5231-01 LUNG c.2634A>C p.P878P COSMIC NP NP 84 TCGA-34-5231-01 LUNG c.3505G>C p.V1169L COSMIC PASSENGER/OTHER Probably Damaging 85 TCGA-37-3783-01 LUNG c.3527G>A p.R1176Q COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-44-6776-01 LUNG c.453G>T p.K151N COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-49-6743-01 LUNG c.2167G>C p.V723L COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-50-5930-01 LUNG c.2228A>T p.N743I COSMIC PASSENGER/OTHER Benign 89 TCGA-50-5930-01 LUNG c.280G>C p.D94H COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-50-6590-01 LUNG c.2178G>T p.E726D COSMIC PASSENGER/OTHER Possibly Damaging 91 TCGA-55-6975-01 LUNG c.1787G>T p.R596L COSMIC PASSENGER/OTHER Benign 92 TCGA-55-7727-01 LUNG c.2884G>A p.D962N COSMIC PASSENGER/OTHER Possibly Damaging 93 TCGA-63-5131-01 LUNG c.1502G>A p.R501Q COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-63-6202-01 LUNG c.1389G>T p.A463A COSMIC NP NP 95 TCGA-67-4679-01 LUNG c.502G>T p.A168S COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-75-6211-01 LUNG c.1487G>A p.R496K COSMIC PASSENGER/OTHER Possibly Damaging 97 TCGA-78-7150-01 LUNG c.1443G>A p.L481L COSMIC NP NP 98 TCGA-78-7539-01 LUNG c.3527G>A p.R1176Q COSMIC PASSENGER/OTHER Probably Damaging 99 TCGA-86-6851-01 LUNG c.719A>T p.K240I COSMIC PASSENGER/OTHER Possibly Damaging 100 TCGA-86-7711-01 LUNG c.3305C>A p.A1102D COSMIC PASSENGER/OTHER Possibly Damaging 101 TCGA-A5-A0G9-01 ENDOMETRIUM c.2856T>C p.I952I COSMIC NP NP 102 TCGA-A6-5666-01 LARGE INTESTINE c.2956T>C p.S986P COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-A6-6781-01 LARGE INTESTINE c.3287G>A p.R1096H COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-A8-A08R-01 BREAST c.1100C>G p.P367R COSMIC PASSENGER/OTHER Possibly Damaging 105 TCGA-AA-3517-01 LARGE INTESTINE c.1786C>T p.R596W COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-AA-3532-01 LARGE INTESTINE c.718A>C p.K240Q COSMIC PASSENGER/OTHER Benign 107 TCGA-AA-3697-01 LARGE INTESTINE c.1617G>T p.S539S COSMIC NP NP 108 TCGA-AA-3715-01 LARGE INTESTINE c.2020C>T p.L674F COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-AA-3715-01 LARGE INTESTINE c.2993A>G p.H998R COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-AA-3858-01 LARGE INTESTINE c.1029G>A p.T343T COSMIC NP NP 111 TCGA-AA-3947-01 LARGE INTESTINE c.3577G>A p.V1193I COSMIC PASSENGER/OTHER Probably Damaging 112 TCGA-AA-A00J-01 LARGE INTESTINE c.258C>A p.S86S COSMIC NP NP 113 TCGA-AA-A00R-01 LARGE INTESTINE c.3567T>G p.I1189M COSMIC PASSENGER/OTHER Probably Damaging 114 TCGA-AA-A01S-01 LARGE INTESTINE c.837G>A p.S279S COSMIC NP NP 115 TCGA-AD-6890-01 LARGE INTESTINE c.1497G>A p.P499P COSMIC NP NP 116 TCGA-AG-3599-01 LARGE INTESTINE c.898C>T p.R300W COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-AG-A002-01 LARGE INTESTINE c.1722C>T p.I574I COSMIC NP NP 118 TCGA-AG-A002-01 LARGE INTESTINE c.2069C>A p.A690D COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-AG-A002-01 LARGE INTESTINE c.490C>T p.R164* COSMIC NP NP 120 TCGA-AG-A00Y-01 LARGE INTESTINE c.2260T>C p.F754L COSMIC PASSENGER/OTHER Benign 121 TCGA-AG-A014-01 LARGE INTESTINE c.2507G>C p.C836S COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-AO-A03N-01 BREAST c.3279G>A p.L1093L COSMIC NP NP 123 TCGA-AP-A051-01 ENDOMETRIUM c.141G>T p.Q47H COSMIC PASSENGER/OTHER Possibly Damaging 124 TCGA-AP-A051-01 ENDOMETRIUM c.147G>A p.A49A COSMIC NP NP 125 TCGA-AP-A051-01 ENDOMETRIUM c.3059G>A p.C1020Y COSMIC PASSENGER/OTHER Probably Damaging 126 TCGA-AP-A051-01 ENDOMETRIUM c.553G>T p.V185F COSMIC PASSENGER/OTHER Possibly Damaging 127 TCGA-AP-A051-01 ENDOMETRIUM c.736G>A p.A246T COSMIC PASSENGER/OTHER Benign 128 TCGA-AP-A056-01 ENDOMETRIUM c.490C>T p.R164* COSMIC NP NP 129 TCGA-AP-A059-01 ENDOMETRIUM c.1792G>A p.E598K COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-AP-A0LD-01 ENDOMETRIUM c.3006G>A p.Q1002Q COSMIC NP NP 131 TCGA-AP-A0LP-01 ENDOMETRIUM c.3661C>T p.R1221C COSMIC PASSENGER/OTHER Probably Damaging 132 TCGA-AU-3779-01 LARGE INTESTINE c.734A>G p.E245G COSMIC PASSENGER/OTHER Benign 133 TCGA-AX-A0J0-01 ENDOMETRIUM c.2262C>T p.F754F COSMIC NP NP 134 TCGA-AX-A0J0-01 ENDOMETRIUM c.2664T>C p.H888H COSMIC NP NP 135 TCGA-AX-A0J1-01 ENDOMETRIUM c.1557C>T p.S519S COSMIC NP NP 136 TCGA-AY-6197-01 LARGE INTESTINE c.1770delC p.P592fs*57 COSMIC NP NP 137 TCGA-AZ-6598-01 LARGE INTESTINE c.1265_1266insG p.R425fs*99 COSMIC NP NP 138 TCGA-AZ-6598-01 LARGE INTESTINE c.3661C>T p.R1221C COSMIC PASSENGER/OTHER Probably Damaging 139 TCGA-B0-4945-01 KIDNEY c.366G>T p.P122P COSMIC NP NP 140 TCGA-B0-5085-01 KIDNEY c.1155A>T p.K385N COSMIC PASSENGER/OTHER Probably Damaging 141 TCGA-B5-A11E-01 ENDOMETRIUM c.2091G>A p.L697L COSMIC NP NP 142 TCGA-B5-A11R-01 ENDOMETRIUM c.1792G>A p.E598K COSMIC PASSENGER/OTHER Probably Damaging 143 TCGA-BG-A0LX-01 ENDOMETRIUM c.3358G>A p.A1120T COSMIC PASSENGER/OTHER Benign 144 TCGA-BG-A0W1-01 ENDOMETRIUM c.1158C>G p.T386T COSMIC NP NP 145 TCGA-BG-A18B-01 ENDOMETRIUM c.1147A>G p.N383D COSMIC PASSENGER/OTHER Possibly Damaging 146 TCGA-BH-A0AZ-01 BREAST c.71C>T p.S24L COSMIC PASSENGER/OTHER Probably Damaging 147 TCGA-BH-A0BW-01 BREAST c.1274G>A p.R425Q COSMIC PASSENGER/OTHER Benign 148 TCGA-BI-A0VR-01 CERVIX c.1509G>A p.T503T COSMIC NP NP 149 TCGA-BS-A0UF-01 ENDOMETRIUM c.2262C>T p.F754F COSMIC NP NP 150 TCGA-BS-A0UF-01 ENDOMETRIUM c.2657C>T p.S886L COSMIC PASSENGER/OTHER Probably Damaging 151 TCGA-CK-6746-01 LARGE INTESTINE c.2022_2023insA p.W677fs*133 COSMIC NP NP 152 TCGA-CM-6162-01 LARGE INTESTINE c.1732C>T p.R578C COSMIC PASSENGER/OTHER Probably Damaging 153 TCGA-CM-6171-01 LARGE INTESTINE c.2399A>G p.E800G COSMIC PASSENGER/OTHER Benign 154 TCGA-D1-A103-01 ENDOMETRIUM c.1727C>T p.S576L COSMIC PASSENGER/OTHER Possibly Damaging 155 TCGA-D1-A16S-01 ENDOMETRIUM c.515G>T p.S172I COSMIC PASSENGER/OTHER Possibly Damaging 156 TCGA-D1-A17D-01 ENDOMETRIUM c.2621G>A p.G874D COSMIC PASSENGER/OTHER Probably Damaging 157 TCGA-D1-A17F-01 ENDOMETRIUM c.3041C>T p.S1014F COSMIC PASSENGER/OTHER Probably Damaging 158 TCGA-D1-A17Q-01 ENDOMETRIUM c.2657C>T p.S886L COSMIC PASSENGER/OTHER Probably Damaging 159 TCGA-D5-6928-01 LARGE INTESTINE c.2289C>T p.G763G COSMIC NP NP 160 TCGA-DI-A0WH-01 ENDOMETRIUM c.2768T>C p.F923S COSMIC PASSENGER/OTHER Probably Damaging 161 TCGA-DM-A1D4-01 LARGE INTESTINE c.733G>T p.E245* COSMIC NP NP 162 TCGA-F4-6856-01 LARGE INTESTINE c.1266delG p.R425fs*36 COSMIC NP NP 163 TCGA-G2-A2EJ-01 URINARY TRACT c.1250C>T p.S417L COSMIC PASSENGER/OTHER Benign 164 TCGA-G4-6315-01 LARGE INTESTINE c.1188G>A p.A396A COSMIC NP NP 165 WA33 PROSTATE c.2148C>G p.H716Q COSMIC PASSENGER/OTHER Possibly Damaging 166 WA48 PROSTATE c.1164A>C p.K388N COSMIC PASSENGER/OTHER Probably Damaging 167 WA56 PROSTATE c.491G>A p.R164Q COSMIC PASSENGER/OTHER Probably Damaging 168 YUFLA SKIN c.1487G>A p.R496K COSMIC PASSENGER/OTHER Possibly Damaging 169 YUFLA SKIN c.1499A>C p.K500T COSMIC PASSENGER/OTHER Possibly Damaging 170 YUNOCA SKIN c.3382A>G p.K1128E COSMIC PASSENGER/OTHER Probably Damaging 171 YURTHE SKIN c.148G>A p.E50K COSMIC PASSENGER/OTHER Benign 172 pfg016T STOMACH c.412delC p.P139fs*168 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PB000728 Pfam-B_728 2 135 9.7e-19 PB000223 Pfam-B_223 66 404 1.3e-19 PF02375 JmjN 558 591 3.4e-12 PF01388 ARID 619 709 2.2e-27 PB001459 Pfam-B_1459 882 945 3.7e-10 PF02373 JmjC 916 1031 2.3e-33 PF02928 zf-C5HC2 1139 1193 9.4e-12 2. Superfamily Domains:Domain ID Start Site End Site E-value 0049275 603 710 1.96e-23 0047105 894 1068 1.07e-11 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR JARID2 JARID2 JARID2 ENSP00000341280 Q92833 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q92833 JARID2 ENSP00000341280 JARID2 Q92833 Expression Atlas Protein Atlas OMIM IntAct PharmGKB JARID2 ENSP00000341280 601594 Q92833 PA29995
