dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80D |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587220 LARGE INTESTINE c.1342C>T p.R448C COSMIC NP NP 2 609 SALIVARY GLAND c.2128C>A p.Q710K COSMIC NP NP 3 631076 LUNG c.1012G>T p.E338* COSMIC NP NP 4 ESO-1481 OESOPHAGUS c.2444C>T p.T815M COSMIC NP NP 5 ESO-916 OESOPHAGUS c.578G>A p.S193N COSMIC NP NP 6 G4 LARGE INTESTINE c.964G>T p.A322S COSMIC NP NP 7 LPJ119 HAEMATOPOIETIC AND LYMPHOID TISSUE c.53C>A p.P18H COSMIC NP NP 8 LPJ119 HAEMATOPOIETIC AND LYMPHOID TISSUE c.57C>G p.N19K COSMIC NP NP 9 LUAD-NYU284 LUNG c.849G>A p.L283L COSMIC NP NP 10 LUAD-RT-S01818 LUNG c.1467G>C p.L489L COSMIC NP NP 11 LUAD-S01356 LUNG c.275C>G p.P92R COSMIC NP NP 12 LUAD-S01357 LUNG c.1258A>T p.K420* COSMIC NP NP 13 LUAD-S01405 LUNG c.183G>C p.V61V COSMIC NP NP 14 PD4601a NS c.2018G>C p.R673T COSMIC NP NP 15 PR-01-1934 PROSTATE c.2387C>G p.S796C COSMIC NP NP 16 T65 ENDOMETRIUM c.1840G>C p.G614R COSMIC NP NP 17 TCGA-05-4430-01 LUNG c.1987A>T p.T663S COSMIC PASSENGER/OTHER Possibly Damaging 18 TCGA-21-1076-01 LUNG c.684A>T p.P228P COSMIC NP NP 19 TCGA-22-4591-01 LUNG c.2631G>T p.Q877H COSMIC NP NP 20 TCGA-24-2298-01 OVARY c.2683A>G p.I895V COSMIC NP NP 21 TCGA-29-1697-01 OVARY c.1787G>T p.G596V COSMIC NP NP 22 TCGA-34-5240-01 LUNG c.2130A>G p.Q710Q COSMIC NP NP 23 TCGA-39-5039-01 LUNG c.1639G>T p.A547S COSMIC NP NP 24 TCGA-50-5946-01 LUNG c.1359C>T p.P453P COSMIC NP NP 25 TCGA-50-5946-02 LUNG c.1359C>T p.P453P COSMIC NP NP 26 TCGA-60-2719-01 LUNG c.555C>T p.F185F COSMIC NP NP 27 TCGA-61-2094-01 OVARY c.2307C>A p.T769T COSMIC NP NP 28 TCGA-69-7765-01 LUNG c.1895G>C p.R632P COSMIC NP NP 29 TCGA-69-7765-01 LUNG c.370G>C p.V124L COSMIC NP NP 30 TCGA-69-7765-01 LUNG c.659G>C p.W220S COSMIC NP NP 31 TCGA-73-4668-01 LUNG c.119C>A p.T40N COSMIC NP NP 32 TCGA-75-6214-01 LUNG c.2254G>T p.A752S COSMIC NP NP 33 TCGA-86-7711-01 LUNG c.1591G>A p.D531N COSMIC NP NP 34 TCGA-97-7938-01 LUNG c.1600G>C p.E534Q COSMIC NP NP 35 TCGA-AA-3710-01 LARGE INTESTINE c.883C>T p.H295Y COSMIC NP NP 36 TCGA-AA-3947-01 LARGE INTESTINE c.275delC p.P92fs*23 COSMIC NP NP 37 TCGA-AA-3950-01 LARGE INTESTINE c.1225delA p.M409fs*5 COSMIC NP NP 38 TCGA-AG-3892-01 LARGE INTESTINE c.2214C>A p.I738I COSMIC NP NP 39 TCGA-AP-A059-01 ENDOMETRIUM c.2362C>T p.L788F COSMIC NP NP 40 TCGA-AP-A0LM-01 ENDOMETRIUM c.545C>T p.A182V COSMIC NP NP 41 TCGA-AX-A05S-01 ENDOMETRIUM c.338_340delCTT p.S113delS COSMIC NP NP 42 TCGA-AX-A05Z-01 ENDOMETRIUM c.1681G>A p.E561K COSMIC NP NP 43 TCGA-AX-A0J1-01 ENDOMETRIUM c.545C>T p.A182V COSMIC NP NP 44 TCGA-AZ-4315-01 LARGE INTESTINE c.545C>T p.A182V COSMIC NP NP 45 TCGA-B5-A0JR-01 ENDOMETRIUM c.608C>T p.T203I COSMIC NP NP 46 TCGA-B5-A11E-01 ENDOMETRIUM c.1640C>A p.A547D COSMIC NP NP 47 TCGA-B5-A11E-01 ENDOMETRIUM c.347C>A p.P116H COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-B5-A11X-01 ENDOMETRIUM c.1355G>A p.R452Q COSMIC NP NP 49 TCGA-BS-A0UV-01 ENDOMETRIUM c.2331C>T p.G777G COSMIC NP NP 50 TCGA-BS-A0UV-01 ENDOMETRIUM c.640C>T p.P214S COSMIC PASSENGER/OTHER Benign 51 TCGA-CA-6717-01 LARGE INTESTINE c.1413C>T p.S471S COSMIC NP NP 52 TCGA-CJ-5678-01 KIDNEY c.1826G>C p.G609A COSMIC NP NP 53 TCGA-CJ-5681-01 KIDNEY c.16T>C p.F6L COSMIC NP NP 54 TCGA-CK-6746-01 LARGE INTESTINE c.2668C>T p.P890S COSMIC NP NP 55 TCGA-CZ-5464-01 KIDNEY c.1485G>A p.P495P COSMIC NP NP 56 TCGA-D5-6534-01 LARGE INTESTINE c.88G>A p.G30R COSMIC NP NP 57 TCGA-D5-6540-01 LARGE INTESTINE c.1225_1226insA p.M409fs*3 COSMIC NP NP 58 TCGA-D5-6930-01 LARGE INTESTINE c.2613C>T p.S871S COSMIC NP NP 59 TCGA-DK-A1A5-01 URINARY TRACT c.1600G>A p.E534K COSMIC NP NP 60 TCGA-DK-A1AB-01 URINARY TRACT c.985A>T p.I329L COSMIC NP NP 61 TCGA-DM-A1D9-01 LARGE INTESTINE c.15C>T p.A5A COSMIC NP NP 62 TCGA-E9-A1R7-01 BREAST c.2429C>A p.S810Y COSMIC NP NP 63 TCGA-EO-A1Y8-01 ENDOMETRIUM c.1180G>T p.D394Y COSMIC NP NP 64 TCGA-F4-6704-01 LARGE INTESTINE c.1552G>C p.D518H COSMIC NP NP 65 TCGA-FU-A23K-01 CERVIX c.694G>C p.E232Q COSMIC NP NP 66 tumor_4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2324T>C p.L775P COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR INO80D INO80D INO80D ENSP00000384198 Q53TQ3 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q53TQ3 INO80D ENSP00000384198 INO80D Q53TQ3 Expression Atlas Protein Atlas OMIM IntAct PharmGKB INO80D ENSP00000384198 NA Q53TQ3 PA162392147
