dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: HDAC9 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 043 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3108_3109insT p.V1037fs*25 COSMIC NP NP 2 043-0094-01TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.3108_3109insT p.V1037fs*25 COSMIC NP NP 3 587222 LARGE INTESTINE c.2358C>G p.H786Q COSMIC NP NP 4 587278 LARGE INTESTINE c.1801G>C p.D601H COSMIC NP NP 5 587304 LARGE INTESTINE c.1883G>A p.R628H COSMIC NP NP 6 587316 LARGE INTESTINE c.68C>A p.P23H COSMIC CANCER Probably Damaging 7 587342 LARGE INTESTINE c.28G>A p.V10M COSMIC PASSENGER/OTHER Probably Damaging 8 587376 LARGE INTESTINE c.1226G>A p.R409Q COSMIC NP NP 9 587376 LARGE INTESTINE c.183G>T p.K61N COSMIC PASSENGER/OTHER Probably Damaging 10 587376 LARGE INTESTINE c.291A>C p.K97N COSMIC NP NP 11 587376 LARGE INTESTINE c.435A>C p.E145D COSMIC NP NP 12 Br25X CENTRAL NERVOUS SYSTEM c.847A>G p.N283D COSMIC NP NP 13 Br27P CENTRAL NERVOUS SYSTEM c.49G>A p.G17S COSMIC PASSENGER/OTHER Benign 14 CHC205T LIVER c.3128T>A p.L1043Q COSMIC NP NP 15 CMML-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1948G>A p.V650I COSMIC NP NP 16 ESO-0053 OESOPHAGUS c.1882C>T p.R628C COSMIC NP NP 17 ESO-105 OESOPHAGUS c.1398C>A p.V466V COSMIC NP NP 18 ESO-116 OESOPHAGUS c.2354A>G p.H785R COSMIC NP NP 19 ESO-160 OESOPHAGUS c.1351C>T p.R451* COSMIC NP NP 20 ESO-1733 OESOPHAGUS c.1948G>A p.V650I COSMIC NP NP 21 ESO-177 OESOPHAGUS c.2540G>A p.R847H COSMIC NP NP 22 H441 LUNG c.67C>A p.P23T COSMIC CANCER Probably Damaging 23 H650 LUNG c.102G>T p.M34I COSMIC PASSENGER/OTHER Benign 24 HCC138T LIVER c.1A>G p.M1V COSMIC PASSENGER/OTHER Probably Damaging 25 HCC6T LIVER c.2600T>A p.L867H COSMIC NP NP 26 HCC72T LIVER c.2636G>A p.G879D COSMIC NP Possibly Damaging 27 HN_0-046 UPPER AERODIGESTIVE TRACT c.486C>T p.D162D COSMIC NP NP 28 HN_62854 UPPER AERODIGESTIVE TRACT c.1551G>T p.A517A COSMIC NP NP 29 LUAD-2GUGK LUNG c.2070G>A p.L690L COSMIC NP NP 30 LUAD-5V8LT LUNG c.1541G>T p.G514V COSMIC NP NP 31 LUAD-B02077 LUNG c.1036G>C p.A346P COSMIC NP NP 32 LUAD-B02077 LUNG c.2566G>T p.G856C COSMIC NP NP 33 LUAD-B02477 LUNG c.963G>T p.L321L COSMIC NP NP 34 LUAD-B02594 LUNG c.2383delT p.F795fs*14 COSMIC NP NP 35 LUAD-CHTN-MAD06-00490 LUNG c.1106G>C p.G369A COSMIC PASSENGER/OTHER Benign 36 LUAD-CHTN-MAD06-00678 LUNG c.2586G>A p.E862E COSMIC NP NP 37 LUAD-CHTN-Z4716A LUNG c.553C>A p.H185N COSMIC NP NP 38 LUAD-E01278 LUNG c.1006G>T p.G336W COSMIC NP NP 39 LUAD-F00368 LUNG c.2514C>A p.P838P COSMIC NP NP 40 LUAD-NYU1051S LUNG c.1830C>T p.S610S COSMIC NP NP 41 LUAD-NYU195 LUNG c.2404G>T p.A802S COSMIC CANCER Probably Damaging 42 LUAD-NYU575 LUNG c.105C>A p.P35P COSMIC NP NP 43 LUAD-RT-S01487 LUNG c.3080G>C p.G1027A COSMIC NP NP 44 LUAD-RT-S01774 LUNG c.2866G>T p.E956* COSMIC NP NP 45 LUAD-RT-S01777 LUNG c.3123C>A p.A1041A COSMIC NP NP 46 LUAD-S01315 LUNG c.3120G>T p.L1040L COSMIC NP NP 47 LUAD-S01357 LUNG c.1551G>A p.A517A COSMIC NP NP 48 LUAD-S01357 LUNG c.963G>T p.L321L COSMIC NP NP 49 LUAD-S01409 LUNG c.1541G>A p.G514E COSMIC NP NP 50 LUAD-S01409 LUNG c.57G>T p.E19D COSMIC PASSENGER/OTHER Benign 51 LUAD-S01478 LUNG c.54G>C p.L18L COSMIC NP NP 52 LUAD-YINHD LUNG c.1270C>G p.Q424E COSMIC NP NP 53 ME002T SKIN c.2045G>A p.R682Q COSMIC NP NP 54 NCI-H1437 LUNG c.1594A>C p.S532R COSMIC PASSENGER/OTHER Possibly Damaging 55 NCI-H2126 LUNG c.1344C>A p.P448P COSMIC NP NP 56 PACA116 PANCREAS c.1103C>T p.P368L COSMIC NP NP 57 PD2127a KIDNEY c.2770C>A p.P924T COSMIC NP NP 58 PD3890a BREAST c.2819C>T p.T940M COSMIC NP NP 59 SJMB008 CENTRAL NERVOUS SYSTEM c.277C>A p.L93I COSMIC NP Benign 60 SJMB043 CENTRAL NERVOUS SYSTEM c.628C>A p.Q210K COSMIC NP Probably Damaging 61 T162 ENDOMETRIUM c.1934T>C p.L645P COSMIC NP NP 62 TCGA-05-4250-01 LUNG c.2379_2380GG>TT p.M793_G794>IW COSMIC NP NP 63 TCGA-05-4410-01 LUNG c.2235G>A p.W745* COSMIC NP NP 64 TCGA-05-5423-01 LUNG c.230G>T p.R77L COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-18-3409-01 LUNG c.2469T>G p.D823E COSMIC NP NP 66 TCGA-18-3409-01 LUNG c.949G>T p.D317Y COSMIC NP NP 67 TCGA-21-1070-01 LUNG c.1448A>C p.Q483P COSMIC NP NP 68 TCGA-21-1070-01 LUNG c.2776C>A p.L926I COSMIC NP NP 69 TCGA-22-5472-01 LUNG c.1916C>T p.A639V COSMIC NP NP 70 TCGA-22-5478-01 LUNG c.1963A>T p.T655S COSMIC NP NP 71 TCGA-33-4533-01 LUNG c.1589C>T p.T530I COSMIC NP NP 72 TCGA-33-4566-01 LUNG c.2698C>A p.P900T COSMIC NP NP 73 TCGA-34-2596-01 LUNG c.1801G>C p.D601H COSMIC NP NP 74 TCGA-34-5240-01 LUNG c.830G>T p.G277V COSMIC NP NP 75 TCGA-35-4123-01 LUNG c.1600A>T p.S534C COSMIC NP Benign 76 TCGA-38-4632-01 LUNG c.1551G>T p.A517A COSMIC NP NP 77 TCGA-43-3394-01 LUNG c.1766C>T p.S589F COSMIC NP NP 78 TCGA-44-2659-01 LUNG c.1382C>G p.T461R COSMIC NP NP 79 TCGA-44-5644-01 LUNG c.1367C>A p.P456H COSMIC NP NP 80 TCGA-44-7662-01 LUNG c.2356C>T p.H786Y COSMIC NP NP 81 TCGA-44-7667-01 LUNG c.114C>A p.D38E COSMIC PASSENGER/OTHER Possibly Damaging 82 TCGA-44-7667-01 LUNG c.1218A>G p.E406E COSMIC NP NP 83 TCGA-46-3769-01 LUNG c.1551G>C p.A517A COSMIC NP NP 84 TCGA-49-6743-01 LUNG c.1527G>A p.E509E COSMIC NP NP 85 TCGA-49-6761-01 LUNG c.1334G>A p.R445H COSMIC NP NP 86 TCGA-50-5946-01 LUNG c.1036G>C p.A346P COSMIC NP NP 87 TCGA-50-5946-01 LUNG c.1644G>C p.V548V COSMIC NP NP 88 TCGA-50-5946-02 LUNG c.1036G>C p.A346P COSMIC NP NP 89 TCGA-50-5946-02 LUNG c.1644G>C p.V548V COSMIC NP NP 90 TCGA-50-7109-01 LUNG c.1946G>T p.C649F COSMIC NP NP 91 TCGA-55-7570-01 LUNG c.652C>T p.L218F COSMIC NP NP 92 TCGA-55-7907-01 LUNG c.2116G>T p.G706C COSMIC NP NP 93 TCGA-59-2348-01 OVARY c.678C>T p.N226N COSMIC NP NP 94 TCGA-64-1679-01 LUNG c.234G>A p.Q78Q COSMIC NP NP 95 TCGA-64-5778-01 LUNG c.1203T>C p.H401H COSMIC NP NP 96 TCGA-66-2742-01 LUNG c.2823G>T p.K941N COSMIC NP NP 97 TCGA-66-2759-01 LUNG c.918G>A p.M306I COSMIC NP NP 98 TCGA-66-2791-01 LUNG c.448C>A p.L150I COSMIC NP NP 99 TCGA-67-3771-01 LUNG c.460C>T p.L154L COSMIC NP NP 100 TCGA-69-7765-01 LUNG c.1522G>T p.A508S COSMIC NP NP 101 TCGA-69-7979-01 LUNG c.2213G>T p.G738V COSMIC NP NP 102 TCGA-69-7979-01 LUNG c.3136G>T p.D1046Y COSMIC NP NP 103 TCGA-69-7979-01 LUNG c.3193G>T p.E1065* COSMIC NP NP 104 TCGA-73-4666-01 LUNG c.2401G>T p.V801F COSMIC NP NP 105 TCGA-78-7150-01 LUNG c.1766C>G p.S589C COSMIC NP NP 106 TCGA-78-7150-01 LUNG c.1791G>T p.A597A COSMIC NP NP 107 TCGA-78-7155-01 LUNG c.3129A>T p.L1043L COSMIC NP NP 108 TCGA-85-6561-01 LUNG c.1348A>G p.N450D COSMIC NP NP 109 TCGA-91-6836-01 LUNG c.1587C>A p.S529R COSMIC PASSENGER/OTHER Benign 110 TCGA-97-7552-01 LUNG c.1882C>T p.R628C COSMIC NP NP 111 TCGA-97-7554-01 LUNG c.1278C>T p.P426P COSMIC NP NP 112 TCGA-99-8028-01 LUNG c.1613T>A p.V538E COSMIC NP NP 113 TCGA-A2-A0D2-01 BREAST c.3178G>A p.G1060S COSMIC NP NP 114 TCGA-A2-A0SV-01 BREAST c.2057G>T p.R686L COSMIC NP NP 115 TCGA-A6-2671-01 LARGE INTESTINE c.1749G>A p.T583T COSMIC NP NP 116 TCGA-A6-3808-01 LARGE INTESTINE c.2540G>A p.R847H COSMIC NP NP 117 TCGA-A6-5661-01 LARGE INTESTINE c.961C>A p.L321M COSMIC CANCER Probably Damaging 118 TCGA-A6-6648-01 LARGE INTESTINE c.1073C>T p.T358M COSMIC NP NP 119 TCGA-A6-6781-01 LARGE INTESTINE c.2227A>G p.T743A COSMIC NP NP 120 TCGA-A6-6782-01 LARGE INTESTINE c.798A>G p.E266E COSMIC NP NP 121 TCGA-AA-3510-01 LARGE INTESTINE c.1041G>A p.S347S COSMIC NP NP 122 TCGA-AA-3664-01 LARGE INTESTINE c.3090G>T p.L1030F COSMIC NP NP 123 TCGA-AA-3710-01 LARGE INTESTINE c.984T>G p.P328P COSMIC NP NP 124 TCGA-AA-3713-01 LARGE INTESTINE c.1594A>G p.S532G COSMIC PASSENGER/OTHER Benign 125 TCGA-AA-3833-01 LARGE INTESTINE c.122T>A p.V41D COSMIC PASSENGER/OTHER Possibly Damaging 126 TCGA-AA-3864-01 LARGE INTESTINE c.255G>T p.E85D COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-AA-3966-01 LARGE INTESTINE c.2412C>T p.T804T COSMIC NP NP 128 TCGA-AA-3972-01 LARGE INTESTINE c.487A>C p.T163P COSMIC NP NP 129 TCGA-AA-3977-01 LARGE INTESTINE c.2557T>G p.F853V COSMIC NP NP 130 TCGA-AA-3984-01 LARGE INTESTINE c.273G>T p.Q91H COSMIC NP NP 131 TCGA-AA-3984-01 LARGE INTESTINE c.2976G>A p.P992P COSMIC NP NP 132 TCGA-AA-A00N-01 LARGE INTESTINE c.1988G>A p.R663Q COSMIC NP NP 133 TCGA-AA-A010-01 LARGE INTESTINE c.2113T>C p.Y705H COSMIC NP NP 134 TCGA-AA-A010-01 LARGE INTESTINE c.219G>T p.E73D COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-AA-A010-01 LARGE INTESTINE c.748G>T p.D250Y COSMIC NP NP 136 TCGA-AD-6964-01 LARGE INTESTINE c.33G>A p.K11K COSMIC NP NP 137 TCGA-AF-6655-01 LARGE INTESTINE c.1749G>A p.T583T COSMIC NP NP 138 TCGA-AG-3893-01 LARGE INTESTINE c.1864C>T p.P622S COSMIC NP NP 139 TCGA-AG-3902-01 LARGE INTESTINE c.1128G>A p.P376P COSMIC NP NP 140 TCGA-AG-A002-01 LARGE INTESTINE c.513C>T p.S171S COSMIC NP NP 141 TCGA-AG-A02N-01 LARGE INTESTINE c.2074G>T p.E692* COSMIC NP NP 142 TCGA-AP-A051-01 ENDOMETRIUM c.3116C>A p.A1039D COSMIC NP NP 143 TCGA-AP-A051-01 ENDOMETRIUM c.933C>T p.R311R COSMIC NP NP 144 TCGA-AP-A051-01 ENDOMETRIUM c.978C>A p.T326T COSMIC NP NP 145 TCGA-AP-A054-01 ENDOMETRIUM c.2350G>T p.G784C COSMIC NP NP 146 TCGA-AP-A056-01 ENDOMETRIUM c.1476G>A p.S492S COSMIC NP NP 147 TCGA-AP-A056-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 148 TCGA-AP-A059-01 ENDOMETRIUM c.365G>A p.R122H COSMIC NP NP 149 TCGA-AP-A0LM-01 ENDOMETRIUM c.1225C>T p.R409* COSMIC NP NP 150 TCGA-AP-A0LM-01 ENDOMETRIUM c.199G>A p.E67K COSMIC PASSENGER/OTHER Probably Damaging 151 TCGA-AP-A0LM-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 152 TCGA-AP-A0LM-01 ENDOMETRIUM c.2222G>C p.S741T COSMIC NP NP 153 TCGA-AR-A251-01 BREAST c.1846C>T p.P616S COSMIC NP Benign 154 TCGA-AX-A0J0-01 ENDOMETRIUM c.1352G>A p.R451Q COSMIC NP NP 155 TCGA-AX-A0J0-01 ENDOMETRIUM c.1428G>T p.E476D COSMIC NP NP 156 TCGA-AX-A0J0-01 ENDOMETRIUM c.2057G>A p.R686Q COSMIC NP NP 157 TCGA-AX-A0J0-01 ENDOMETRIUM c.2789A>C p.K930T COSMIC NP NP 158 TCGA-AZ-4315-01 LARGE INTESTINE c.1225C>T p.R409* COSMIC NP NP 159 TCGA-AZ-4315-01 LARGE INTESTINE c.1791G>A p.A597A COSMIC NP NP 160 TCGA-AZ-6598-01 LARGE INTESTINE c.2795C>T p.T932M COSMIC NP NP 161 TCGA-B0-5098-01 KIDNEY c.1569G>A p.A523A COSMIC NP NP 162 TCGA-B0-5104-01 KIDNEY c.1253G>T p.G418V COSMIC NP NP 163 TCGA-B5-A0JY-01 ENDOMETRIUM c.1216G>T p.E406* COSMIC NP NP 164 TCGA-B5-A11E-01 ENDOMETRIUM c.1720T>C p.F574L COSMIC NP NP 165 TCGA-BG-A18B-01 ENDOMETRIUM c.138G>A p.L46L COSMIC NP NP 166 TCGA-BP-4983-01 KIDNEY c.172C>A p.Q58K COSMIC PASSENGER/OTHER Benign 167 TCGA-BS-A0T9-01 ENDOMETRIUM c.2213G>T p.G738V COSMIC NP NP 168 TCGA-BS-A0UF-01 ENDOMETRIUM c.1699G>T p.E567* COSMIC NP NP 169 TCGA-BS-A0UV-01 ENDOMETRIUM c.2045G>A p.R682Q COSMIC NP NP 170 TCGA-BT-A3PH-01 URINARY TRACT c.1749G>A p.T583T COSMIC NP NP 171 TCGA-C4-A0F1-01 URINARY TRACT c.2883C>G p.L961L COSMIC NP NP 172 TCGA-CA-5254-01 LARGE INTESTINE c.1728A>T p.Q576H COSMIC NP NP 173 TCGA-CF-A1HS-01 URINARY TRACT c.2813A>T p.H938L COSMIC NP NP 174 TCGA-CI-6624-01 LARGE INTESTINE c.2909C>A p.A970D COSMIC NP NP 175 TCGA-CK-4952-01 LARGE INTESTINE c.3138T>C p.D1046D COSMIC NP NP 176 TCGA-CK-5914-01 LARGE INTESTINE c.1344C>A p.P448P COSMIC NP NP 177 TCGA-CM-5861-01 LARGE INTESTINE c.1874C>A p.A625E COSMIC NP NP 178 TCGA-CM-5864-01 LARGE INTESTINE c.2539C>T p.R847C COSMIC NP NP 179 TCGA-D1-A167-01 ENDOMETRIUM c.2493G>A p.Q831Q COSMIC NP NP 180 TCGA-D1-A176-01 ENDOMETRIUM c.2921C>T p.A974V COSMIC NP NP 181 TCGA-DK-A1AC-01 URINARY TRACT c.1494G>A p.L498L COSMIC NP NP 182 TCGA-DM-A1D9-01 LARGE INTESTINE c.1761G>A p.A587A COSMIC NP NP 183 TCGA-DR-A0ZM-01 CERVIX c.2093C>T p.S698F COSMIC NP NP 184 TCGA-EJ-7331-01 PROSTATE c.1074G>A p.T358T COSMIC NP NP 185 TCGA-F4-6570-01 LARGE INTESTINE c.213G>A p.Q71Q COSMIC NP NP 186 TCGA-FU-A23L-01 CERVIX c.1096C>T p.P366S COSMIC NP NP 187 TCGA-G4-6586-01 LARGE INTESTINE c.1661_1667delCAGTGGA p.D556fs*46 COSMIC NP NP 188 TCGA-G4-6588-01 LARGE INTESTINE c.542C>T p.T181M COSMIC NP NP 189 TCGA-G4-6628-01 LARGE INTESTINE c.2494C>T p.Q832* COSMIC NP NP 190 WA16 PROSTATE c.2795C>T p.T932M COSMIC NP NP 191 ccRCC-105 KIDNEY c.2312G>A p.G771E COSMIC NP NP 192 ccRCC-26 KIDNEY c.2776C>A p.L926I COSMIC NP NP 193 ccRCC-42 KIDNEY c.1825G>C p.V609L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR HDAC9 HDAC9 HDAC9 ENSP00000383912 Q9UKV0 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UKV0 HDAC9 ENSP00000383912 HDAC9 Q9UKV0 Expression Atlas Protein Atlas OMIM IntAct PharmGKB HDAC9 ENSP00000383912 606543 Q9UKV0 PA38377
