dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: FBXO10 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 112281 LUNG c.2191C>T p.H731Y COSMIC PASSENGER/OTHER Benign 2 18D HAEMATOPOIETIC AND LYMPHOID TISSUE c.1520A>G p.N507S COSMIC PASSENGER/OTHER Probably Damaging 3 2334192 LUNG c.1451G>C p.C484S COSMIC PASSENGER/OTHER Probably Damaging 4 2334196 LUNG c.2624A>T p.Q875L COSMIC NP NP 5 587234 LARGE INTESTINE c.2723C>T p.T908M COSMIC NP NP 6 631076 LUNG c.483G>T p.L161F COSMIC PASSENGER/OTHER Probably Damaging 7 86319 LUNG c.116G>A p.S39N COSMIC PASSENGER/OTHER Probably Damaging 8 86319 LUNG c.1662G>A p.K554K COSMIC NP NP 9 86503 LUNG c.1159G>T p.G387C COSMIC PASSENGER/OTHER Probably Damaging 10 86793 LUNG c.1829G>T p.G610V COSMIC PASSENGER/OTHER Possibly Damaging 11 ESO-0009 OESOPHAGUS c.2112G>A p.W704* COSMIC NP NP 12 ESO-859 OESOPHAGUS c.2259C>T p.H753H COSMIC NP NP 13 ESO-859 OESOPHAGUS c.679A>G p.T227A COSMIC PASSENGER/OTHER Benign 14 HCC68T LIVER c.2800C>T p.Q934* COSMIC NP NP 15 HN_62493 UPPER AERODIGESTIVE TRACT c.2170G>A p.V724I COSMIC PASSENGER/OTHER Benign 16 LC_C28 LUNG c.2588G>T p.R863L COSMIC NP NP 17 LUAD-B02077 LUNG c.1099G>T p.E367* COSMIC NP NP 18 LUAD-NYU284 LUNG c.1607T>C p.V536A COSMIC PASSENGER/OTHER Probably Damaging 19 LUAD-S00488 LUNG c.1054G>T p.D352Y COSMIC PASSENGER/OTHER Probably Damaging 20 LXFL529 LUNG c.1766G>A p.G589D COSMIC PASSENGER/OTHER Probably Damaging 21 P09-2497 PROSTATE c.2136C>T p.D712D COSMIC NP NP 22 TCGA-05-4433-01 LUNG c.394G>C p.D132H COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-21-5786-01 LUNG c.1170G>A p.L390L COSMIC NP NP 24 TCGA-22-4595-01 LUNG c.14G>T p.G5V COSMIC PASSENGER/OTHER Possibly Damaging 25 TCGA-33-4532-01 LUNG c.2581C>T p.R861W COSMIC NP NP 26 TCGA-35-4123-01 LUNG c.2552A>T p.H851L COSMIC NP NP 27 TCGA-39-5031-01 LUNG c.558A>T p.P186P COSMIC NP NP 28 TCGA-55-6971-01 LUNG c.300A>G p.L100L COSMIC NP NP 29 TCGA-64-5774-01 LUNG c.1254G>A p.K418K COSMIC NP NP 30 TCGA-A6-5661-01 LARGE INTESTINE c.1454G>A p.R485Q COSMIC PASSENGER/OTHER Benign 31 TCGA-AA-3672-01 LARGE INTESTINE c.656G>A p.G219D COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-AA-3710-01 LARGE INTESTINE c.2546G>A p.R849Q COSMIC NP NP 33 TCGA-AA-3845-01 LARGE INTESTINE c.1993G>A p.V665I COSMIC PASSENGER/OTHER Benign 34 TCGA-AA-3864-01 LARGE INTESTINE c.1759G>A p.G587S COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-AA-3877-01 LARGE INTESTINE c.1930G>A p.A644T COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-AA-3947-01 LARGE INTESTINE c.2556G>A p.S852S COSMIC NP NP 37 TCGA-AA-3949-01 LARGE INTESTINE c.1017G>T p.E339D COSMIC PASSENGER/OTHER Benign 38 TCGA-AA-A010-01 LARGE INTESTINE c.2541G>T p.K847N COSMIC NP NP 39 TCGA-AA-A02W-01 LARGE INTESTINE c.711C>T p.N237N COSMIC NP NP 40 TCGA-AA-A02Y-01 LARGE INTESTINE c.2009T>A p.L670Q COSMIC PASSENGER/OTHER Probably Damaging 41 TCGA-AD-6889-01 LARGE INTESTINE c.2289C>A p.A763A COSMIC NP NP 42 TCGA-AD-6889-01 LARGE INTESTINE c.2473C>T p.R825W COSMIC PASSENGER/OTHER Probably Damaging 43 TCGA-AD-6964-01 LARGE INTESTINE c.1877G>T p.G626V COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-AG-A02N-01 LARGE INTESTINE c.695A>G p.H232R COSMIC PASSENGER/OTHER Benign 45 TCGA-AP-A051-01 ENDOMETRIUM c.1329C>T p.G443G COSMIC NP NP 46 TCGA-AP-A059-01 ENDOMETRIUM c.1335C>T p.F445F COSMIC NP NP 47 TCGA-AP-A0LD-01 ENDOMETRIUM c.33G>A p.W11* COSMIC NP NP 48 TCGA-AP-A0LM-01 ENDOMETRIUM c.1335C>T p.F445F COSMIC NP NP 49 TCGA-AP-A0LM-01 ENDOMETRIUM c.2616C>A p.I872I COSMIC NP NP 50 TCGA-AR-A0TP-01 BREAST c.2857A>C p.S953R COSMIC NP NP 51 TCGA-AX-A060-01 ENDOMETRIUM c.2089G>A p.E697K COSMIC PASSENGER/OTHER Possibly Damaging 52 TCGA-AX-A0J0-01 ENDOMETRIUM c.23T>C p.L8S COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-AZ-4315-01 LARGE INTESTINE c.320G>A p.R107Q COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-AZ-6601-01 LARGE INTESTINE c.2136C>T p.D712D COSMIC NP NP 55 TCGA-B5-A11E-01 ENDOMETRIUM c.1400G>A p.R467Q COSMIC PASSENGER/OTHER Benign 56 TCGA-B5-A11Y-01 ENDOMETRIUM c.1062C>T p.S354S COSMIC NP NP 57 TCGA-BP-5201-01 KIDNEY c.2474G>A p.R825Q COSMIC PASSENGER/OTHER Benign 58 TCGA-BS-A0UF-01 ENDOMETRIUM c.2768C>A p.S923Y COSMIC NP NP 59 TCGA-BS-A0UV-01 ENDOMETRIUM c.2619C>A p.I873I COSMIC NP NP 60 TCGA-BS-A0UV-01 ENDOMETRIUM c.423C>T p.Y141Y COSMIC NP NP 61 TCGA-CK-5913-01 LARGE INTESTINE c.2392G>T p.G798C COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-CK-6746-01 LARGE INTESTINE c.734delA p.N245fs*12 COSMIC NP NP 63 TCGA-CM-6171-01 LARGE INTESTINE c.2149C>T p.R717W COSMIC PASSENGER/OTHER Benign 64 TCGA-D1-A101-01 ENDOMETRIUM c.1730G>A p.R577H COSMIC PASSENGER/OTHER Benign 65 TCGA-D1-A103-01 ENDOMETRIUM c.1298G>A p.R433H COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-D1-A103-01 ENDOMETRIUM c.1929C>T p.Y643Y COSMIC NP NP 67 TCGA-D1-A103-01 ENDOMETRIUM c.2588G>A p.R863H COSMIC NP NP 68 TCGA-D1-A16X-01 ENDOMETRIUM c.423C>T p.Y141Y COSMIC NP NP 69 TCGA-D1-A17H-01 ENDOMETRIUM c.230A>G p.Q77R COSMIC CANCER Possibly Damaging 70 TCGA-D1-A17Q-01 ENDOMETRIUM c.2768C>A p.S923Y COSMIC NP NP 71 TCGA-D8-A1JL-01 BREAST c.2173G>C p.E725Q COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-E2-A15M-01 BREAST c.939C>T p.I313I COSMIC NP NP 73 TCGA-EJ-5515-01 PROSTATE c.2614A>G p.I872V COSMIC NP NP 74 TCGA-FI-A2EX-01 ENDOMETRIUM c.1790G>A p.R597H COSMIC PASSENGER/OTHER Possibly Damaging 75 TCGA-G4-6628-01 LARGE INTESTINE c.1881G>T p.V627V COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR FBXO10 FBXO10 FBXO10 ENSP00000403802 Q9UK96 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UK96 FBXO10 ENSP00000403802 FBXO10 Q9UK96 Expression Atlas Protein Atlas OMIM IntAct PharmGKB FBXO10 ENSP00000403802 609092 Q9UK96 PA28030
