dbEM

Protein: EZH2

Mutation Data (+)

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	22RV1	PROSTATE	c.1345C>T	p.L449F	CCLE	NP	NP
2	ACCS	URINARY TRACT	c.1318_1319insG	p.R440fs	CCLE	NP	NP
3	BT20	BREAST	c.1318_1319insG	p.R440fs	CCLE	NP	NP
4	CALU6	LUNG	c.3797C>T	p.S1266F	CCLE	NP	NP
5	CHL1	SKIN	c.1318_1319insG	p.R440fs	CCLE	NP	NP
6	CW2	LARGE INTESTINE	c.1352_1353insGG	p.E451fs	CCLE	NP	NP
7	ECC10	STOMACH	c.1318_1319insG	p.R440fs	CCLE	NP	NP
8	FU97	STOMACH	c.1318_1319insG	p.R440fs	CCLE	NP	NP
9	HCT15	LARGE INTESTINE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
10	HEC251	ENDOMETRIUM	c.1315G>A	p.D439N	CCLE	NP	NP
11	HEPG2	LIVER	c.1318_1319insG	p.R440fs	CCLE	NP	NP
12	HS944T	SKIN	c.1318_1319insG	p.R440fs	CCLE	NP	NP
13	HS944T	SKIN	c.1694C>T	p.S565F	CCLE	NP	NP
14	KATOIII	STOMACH	c.1318_1319insG	p.R440fs	CCLE	NP	NP
15	KLE	ENDOMETRIUM	c.4894G>C	p.D1632H	CCLE	NP	NP
16	KYSE180	OESOPHAGUS	c.954_954delA	p.K318fs	CCLE	NP	NP
17	LP1	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.919A>G	p.K307E	CCLE	PASSENGER/OTHER	Probably Damaging
18	LU99	LUNG	c.4001C>T	p.A1334V	CCLE	NP	NP
19	MFE319	ENDOMETRIUM	c.3553A>G	p.M1185V	CCLE	NP	NP
20	MOLT13	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.3697G>A	p.V1233M	CCLE	NP	NP
21	MUTZ3	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
22	NALM6	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.3467G>A	p.R1156Q	CCLE	NP	NP
23	NCIH1930	LUNG	c.1318_1319insG	p.R440fs	CCLE	NP	NP
24	NCIH1963	LUNG	c.1318_1319insG	p.R440fs	CCLE	NP	NP
25	NCIH2106	LUNG	c.981T>G	p.I327M	CCLE	NP	NP
26	NCIH2110	LUNG	c.4174G>C	p.E1392Q	CCLE	NP	NP
27	NIHOVCAR3	OVARY	c.341G>A	p.R114K	CCLE	NP	NP
28	NUGC3	STOMACH	c.4223C>A	p.P1408H	CCLE	NP	NP
29	ONCODG1	OVARY	c.341G>A	p.R114K	CCLE	NP	NP
30	OSRC2	KIDNEY	c.1318_1319insG	p.R440fs	CCLE	NP	NP
31	PECAPJ49	UPPER AERODIGESTIVE TRACT	c.981T>G	p.I327M	CCLE	NP	NP
32	QGP1	PANCREAS	c.1318_1319insG	p.R440fs	CCLE	NP	NP
33	REH	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.328G>A	p.G110R	CCLE	NP	NP
34	RPMI8226	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
35	SNU1040	LARGE INTESTINE	c.1382G>A	p.R461H	CCLE	NP	NP
36	SNU1079	BILIARY TRACT	c.1318_1319insG	p.R440fs	CCLE	NP	NP
37	SNU520	STOMACH	c.1318_1319insG	p.R440fs	CCLE	NP	NP
38	SNU886	LIVER	c.410C>G	p.T137R	CCLE	NP	NP
39	SW403	LARGE INTESTINE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
40	SW48	LARGE INTESTINE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
41	SW620	LARGE INTESTINE	c.1807C>A	p.L603M	CCLE	NP	NP
42	TE159T	SOFT TISSUE	c.1318_1319insG	p.R440fs	CCLE	NP	NP
43	TGBC11TKB	STOMACH	c.1318_1319insG	p.R440fs	CCLE	NP	NP
44	UMUC1	URINARY TRACT	c.1318_1319insG	p.R440fs	CCLE	NP	NP
45	VMRCLCP	LUNG	c.710A>T	p.E237V	CCLE	NP	NP
46	YD38	UPPER AERODIGESTIVE TRACT	c.1318_1319insG	p.R440fs	CCLE	NP	NP
47	00-15694	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
48	01-19969	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
49	02-22023	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
50	02-24725	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
51	02-30647	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
52	03-26817	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
53	03-30438	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
54	03-30549	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
55	05-11328	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
56	05-12224	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
57	05-15797	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2075C>T	p.A692V	COSMIC	NP	NP
58	05-24006	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
59	05-32947	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
60	06-15922	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
61	06-24718	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
62	06-33777	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
63	07-30109	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
64	1327777	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
65	1327778	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
66	1327779	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
67	1327781	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
68	1327782	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
69	1327783	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
70	1327784	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
71	1327785	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
72	1327786	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
73	1327787	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
74	1327788	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
75	1327789	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1920T>A	p.N640K	COSMIC	NP	NP
76	1327789	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
77	1327790	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
78	1327791	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
79	1327792	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
80	1328628	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
81	1328629	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
82	1328631	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
83	1328634	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
84	1328636	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
85	1328638	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
86	1328687	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
87	1328688	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
88	1328689	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
89	1328690	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
90	1328691	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
91	1328692	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
92	1328693	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
93	1328694	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
94	1328695	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
95	1328696	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
96	1328697	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
97	1328698	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
98	1328699	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
99	1328700	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
100	1328701	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
101	1328702	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
102	1328703	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
103	1328704	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
104	1328770	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
105	1328883	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
106	1328884	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
107	1328885	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
108	1328886	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
109	1328887	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
110	1328888	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
111	1328889	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
112	1328890	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
113	1328891	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
114	1328892	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
115	1328893	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
116	1328894	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
117	139	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2187_2188insT	p.D730fs*1	COSMIC	NP	NP
118	1431674	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.745G>A	p.E249K	COSMIC	PASSENGER/OTHER	Possibly Damaging
119	1431677	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2020T>G	p.L674V	COSMIC	NP	Probably Damaging
120	1431687	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1119_1120insC	p.T374fs*3	COSMIC	NP	NP
121	1431688	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.703_703G>AA	p.G235fs*11	COSMIC	NP	NP
122	1431689	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1983_1983delA	p.V662fs*13	COSMIC	NP	NP
123	1431689	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2068C>T	p.R690C	COSMIC	NP	NP
124	1431690	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2025C>A	p.N675K	COSMIC	NP	NP
125	1431701	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1212_1216delGAAGA	p.K405fs*2	COSMIC	NP	NP
126	1451273	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
127	1465460	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
128	1465461	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
129	1465462	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2078A>C	p.N693T	COSMIC	NP	NP
130	1465463	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2080C>T	p.H694Y	COSMIC	NP	NP
131	1465464	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2143_2143delA	p.I715fs*25	COSMIC	NP	NP
132	1465465	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2180_2182TGT>GG	p.L727fs*13	COSMIC	NP	NP
133	1465906	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2054_2054delA	p.K685fs*12	COSMIC	NP	NP
134	1465908	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.982C>T	p.Q328*	COSMIC	NP	NP
135	1465909	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1992T>G	p.D664E	COSMIC	NP	NP
136	1465910	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.863G>A	p.R288Q	COSMIC	PASSENGER/OTHER	Possibly Damaging
137	1465912	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2187_2188insT	p.D730fs*1	COSMIC	NP	NP
138	1465913	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.619C>T	p.R207*	COSMIC	NP	NP
139	1465916	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1728C>G	p.C576W	COSMIC	NP	NP
140	1465917	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1992T>A	p.D664E	COSMIC	NP	NP
141	1465918	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.786_787insC	p.N263fs*8	COSMIC	NP	NP
142	1465919	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1691_1691delG	p.G564fs*111	COSMIC	NP	NP
143	1465919	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.73C>T	p.R25*	COSMIC	NP	NP
144	1465920	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2068C>T	p.R690C	COSMIC	NP	NP
145	1465921	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2050C>T	p.R684C	COSMIC	NP	NP
146	1465922	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1200_1203delAGAA	p.E401fs*22	COSMIC	NP	NP
147	1465923	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.188_189insA	p.R64fs*18	COSMIC	NP	NP
148	1465924	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.574G>A	p.D192N	COSMIC	PASSENGER/OTHER	Benign
149	1465925	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2079T>A	p.N693K	COSMIC	NP	NP
150	1465926	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1033G>A	p.A345T	COSMIC	NP	Benign
151	1465927	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.754C>G	p.L252V	COSMIC	PASSENGER/OTHER	Benign
152	1465928	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2138T>C	p.I713T	COSMIC	NP	NP
153	1465929	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1992_1997delTAAATA	p.K665_Y666del	COSMIC	NP	NP
154	1465929	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2187_2188insT	p.D730fs*1	COSMIC	NP	NP
155	1465930	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.727A>C	p.K243Q	COSMIC	PASSENGER/OTHER	Probably Damaging
156	1465931	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.763G>A	p.A255T	COSMIC	PASSENGER/OTHER	Probably Damaging
157	1465932	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2050C>T	p.R684C	COSMIC	NP	NP
158	1465932	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.444_445insGAA	p.E148_L149insE	COSMIC	NP	NP
159	1465933	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1966_1966delG	p.A656fs*19	COSMIC	NP	NP
160	1465934	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1967C>T	p.A656V	COSMIC	NP	NP
161	1465934	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.745G>A	p.E249K	COSMIC	PASSENGER/OTHER	Possibly Damaging
162	1465935	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.755_756insC	p.G254fs*6	COSMIC	NP	NP
163	1465936	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2191T>G	p.Y731D	COSMIC	NP	NP
164	1465937	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1712G>A	p.C571Y	COSMIC	PASSENGER/OTHER	Probably Damaging
165	1465937	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.172C>T	p.Q58*	COSMIC	NP	NP
166	1465938	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.730T>G	p.Y244D	COSMIC	PASSENGER/OTHER	Probably Damaging
167	1465938	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.890A>G	p.H297R	COSMIC	PASSENGER/OTHER	Possibly Damaging
168	1465939	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1978G>C	p.G660R	COSMIC	NP	NP
169	1465939	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.216_217delTT	p.S73fs*8	COSMIC	NP	NP
170	1465940	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.434T>G	p.F145C	COSMIC	PASSENGER/OTHER	Probably Damaging
171	1465941	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1175_1176delAA	p.E392fs*7	COSMIC	NP	NP
172	1465942	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1774_1777delACTT	p.T592fs*82	COSMIC	NP	NP
173	1465943	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.965A>G	p.N322S	COSMIC	NP	NP
174	1465944	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1991A>T	p.D664V	COSMIC	NP	NP
175	1465945	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2078A>T	p.N693I	COSMIC	NP	NP
176	1465946	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.949G>T	p.E317*	COSMIC	NP	NP
177	1465947	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1513_1513delG	p.A505fs*9	COSMIC	NP	NP
178	1465948	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.184C>T	p.Q62*	COSMIC	NP	NP
179	1466551	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2199C>A	p.Y733*	COSMIC	NP	NP
180	1466552	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2199C>A	p.Y733*	COSMIC	NP	NP
181	1466553	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
182	1466554	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
183	1466555	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
184	1479175	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
185	1479176	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
186	1479177	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
187	1479178	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
188	1479179	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
189	1479180	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
190	1479181	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
191	1479182	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
192	1479183	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
193	1479184	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
194	1479185	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
195	1479186	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
196	1479187	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
197	1479188	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
198	1479189	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
199	1479190	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
200	1479191	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
201	1479192	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
202	1479193	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
203	1479194	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
204	1479195	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
205	1479196	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
206	1479197	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
207	1479198	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
208	1479199	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
209	1479200	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
210	15	OVARY	c.450_450delA	p.N152fs*15	COSMIC	NP	NP
211	1515069	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
212	1515070	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
213	1515071	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1907C>T	p.P636L	COSMIC	NP	NP
214	1524413	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.475G>A	p.G159R	COSMIC	PASSENGER/OTHER	Probably Damaging
215	1581423	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2035G>A	p.V679M	COSMIC	NP	NP
216	1581424	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2035G>A	p.V679M	COSMIC	NP	NP
217	1581425	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2035G>A	p.V679M	COSMIC	NP	NP
218	1581426	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.965A>G	p.N322S	COSMIC	NP	NP
219	1581427	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.965A>G	p.N322S	COSMIC	NP	NP
220	1581428	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.965A>G	p.N322S	COSMIC	NP	NP
221	1581429	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.863G>A	p.R288Q	COSMIC	PASSENGER/OTHER	Possibly Damaging
222	1581430	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.446T>A	p.L149Q	COSMIC	PASSENGER/OTHER	Probably Damaging
223	1581431	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2110G>C	p.V704L	COSMIC	NP	NP
224	1581432	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.449T>C	p.I150T	COSMIC	PASSENGER/OTHER	Possibly Damaging
225	1581433	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2029G>C	p.D677H	COSMIC	NP	NP
226	1581434	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1718C>T	p.T573I	COSMIC	NP	NP
227	1581435	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1718C>T	p.T573I	COSMIC	NP	NP
228	1581436	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
229	1581437	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
230	1581438	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.403G>A	p.G135R	COSMIC	PASSENGER/OTHER	Probably Damaging
231	1581439	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1697G>A	p.R566H	COSMIC	NP	NP
232	1581440	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.187C>T	p.R63*	COSMIC	NP	NP
233	1581441	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.394C>T	p.P132S	COSMIC	PASSENGER/OTHER	Possibly Damaging
234	1581442	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.179G>A	p.W60*	COSMIC	NP	NP
235	1581442	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2177A>T	p.E726V	COSMIC	NP	NP
236	1581443	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.434T>C	p.F145S	COSMIC	PASSENGER/OTHER	Possibly Damaging
237	1581444	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1682G>A	p.R561H	COSMIC	PASSENGER/OTHER	Benign
238	1581445	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1657C>T	p.Q553*	COSMIC	NP	NP
239	1581446	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2187_2188insT	p.D730fs*1	COSMIC	NP	NP
240	1581447	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2199C>A	p.Y733*	COSMIC	NP	NP
241	159	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.949_950delGA	p.E317fs*29	COSMIC	NP	NP
242	1614052	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
243	1614053	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
244	1614054	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
245	1614055	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
246	1614056	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
247	1614057	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
248	1614058	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
249	1614059	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
250	1614060	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
251	1614061	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
252	1614062	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
253	1614063	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
254	1614064	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
255	1614065	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
256	1614066	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
257	1614067	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
258	1614068	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
259	1614069	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
260	1614070	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
261	1625949	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.435C>A	p.F145L	COSMIC	PASSENGER/OTHER	Possibly Damaging
262	1625950	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.387T>A	p.H129Q	COSMIC	PASSENGER/OTHER	Benign
263	1625950	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.397T>C	p.Y133H	COSMIC	PASSENGER/OTHER	Benign
264	1625950	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.475G>A	p.G159R	COSMIC	PASSENGER/OTHER	Probably Damaging
265	1625951	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1742C>T	p.A581V	COSMIC	NP	NP
266	1626061	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1216_1219delAAAG	p.K406fs*17	COSMIC	NP	NP
267	1626063	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.797G>A	p.G266E	COSMIC	PASSENGER/OTHER	Probably Damaging
268	1626135	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2226_2227insAAAACC	p.V742_G743insKT	COSMIC	NP	NP
269	17	OVARY	c.1559A>C	p.N520T	COSMIC	NP	NP
270	1717055	PARATHYROID	c.1936T>A	p.Y646N	COSMIC	NP	NP
271	1717121	PARATHYROID	c.1936T>A	p.Y646N	COSMIC	NP	NP
272	1737743	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.324_324delC	p.I109fs*1	COSMIC	NP	NP
273	1737745	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1697G>A	p.R566H	COSMIC	NP	NP
274	1861679	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
275	1861680	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
276	1861681	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
277	1861683	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
278	1861684	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
279	1861685	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
280	1861687	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
281	1861688	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
282	1861689	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
283	1861690	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
284	1861691	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
285	1861697	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
286	1861698	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
287	1861699	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
288	1861700	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
289	1861701	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
290	187	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.862C>T	p.R288*	COSMIC	NP	NP
291	1874576	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2079T>A	p.N693K	COSMIC	NP	NP
292	1874580	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1991A>G	p.D664G	COSMIC	NP	NP
293	1925954	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.65_66delAG	p.E22fs*14	COSMIC	NP	NP
294	1925955	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.305A>G	p.N102S	COSMIC	PASSENGER/OTHER	Benign
295	1925956	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2020T>G	p.L674V	COSMIC	NP	Probably Damaging
296	1925957	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.305A>G	p.N102S	COSMIC	PASSENGER/OTHER	Benign
297	1925958	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1657C>T	p.Q553*	COSMIC	NP	NP
298	1925959	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2045C>T	p.A682V	COSMIC	NP	NP
299	1925960	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2228_2229insGCCCCG	p.G743_I744insPR	COSMIC	NP	NP
300	1925961	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2232_2233insATC	p.I744_E745insI	COSMIC	NP	NP
301	1925961	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.933_933T>GGCATA	p.Y311fs*1	COSMIC	NP	NP
302	1925962	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1642_1643insT	p.C548fs*2	COSMIC	NP	NP
303	1925963	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1487A>G	p.K496R	COSMIC	NP	NP
304	1925964	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1526G>C	p.R509T	COSMIC	NP	NP
305	1925965	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1588C>A	p.H530N	COSMIC	NP	NP
306	1925966	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1436C>A	p.S479Y	COSMIC	NP	NP
307	2334195	LUNG	c.118A>T	p.S40C	COSMIC	PASSENGER/OTHER	Benign
308	48	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.13G>T	p.G5W	COSMIC	PASSENGER/OTHER	Probably Damaging
309	52	LIVER	c.1135G>T	p.E379*	COSMIC	NP	NP
310	52	LIVER	c.863G>A	p.R288Q	COSMIC	PASSENGER/OTHER	Possibly Damaging
311	57	OVARY	c.1969G>C	p.D657H	COSMIC	NP	NP
312	587220	LARGE INTESTINE	c.898T>C	p.C300R	COSMIC	NP	NP
313	587342	LARGE INTESTINE	c.1072C>T	p.R358C	COSMIC	NP	NP
314	587376	LARGE INTESTINE	c.1283A>C	p.N428T	COSMIC	NP	NP
315	587376	LARGE INTESTINE	c.2173G>A	p.E725K	COSMIC	NP	NP
316	587376	LARGE INTESTINE	c.507A>C	p.E169D	COSMIC	PASSENGER/OTHER	Benign
317	79	OVARY	c.1876G>A	p.V626M	COSMIC	NP	NP
318	96-20883	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
319	99-27137	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
320	CD563285	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1477C>T	p.P493S	COSMIC	NP	NP
321	CD564308	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2045C>G	p.A682G	COSMIC	NP	NP
322	CD564333	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
323	CD564341	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
324	CD564591	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
325	CD564672	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
326	CHC051T	LIVER	c.2024A>G	p.N675S	COSMIC	NP	NP
327	CMML-01	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2152_2153delAA	p.K718fs*12	COSMIC	NP	NP
328	DB	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
329	DLBCL-PatientA	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
330	DLBCL-PatientC	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
331	DLBCL-PatientD	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
332	DLBCL-PatientG	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2045C>G	p.A682G	COSMIC	NP	NP
333	DLBCL-PatientL	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
334	DLBCL832	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
335	ELF-153	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1525A>G	p.R509G	COSMIC	NP	NP
336	ESO-1133	OESOPHAGUS	c.1012G>C	p.E338Q	COSMIC	NP	NP
337	ESO-177	OESOPHAGUS	c.512T>C	p.F171S	COSMIC	PASSENGER/OTHER	Probably Damaging
338	ESO-408	OESOPHAGUS	c.1477C>T	p.P493S	COSMIC	NP	NP
339	FL-PatientA	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
340	FL001	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
341	FL009	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
342	FL012	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
343	H1155	LUNG	c.1610G>A	p.S537N	COSMIC	NP	NP
344	HCC101T	LIVER	c.492G>T	p.G164G	COSMIC	NP	NP
345	HN_62825	UPPER AERODIGESTIVE TRACT	c.791T>G	p.I264R	COSMIC	PASSENGER/OTHER	Probably Damaging
346	HN_63081	UPPER AERODIGESTIVE TRACT	c.542A>G	p.Y181C	COSMIC	PASSENGER/OTHER	Possibly Damaging
347	HN_63115	UPPER AERODIGESTIVE TRACT	c.1613C>T	p.S538L	COSMIC	NP	NP
348	HS0804	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>C	p.Y646H	COSMIC	NP	NP
349	ID39	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2083T>C	p.S695P	COSMIC	NP	NP
350	KARPAS-422	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
351	KARPAS_422	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
352	Karpas422	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
353	L-428	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
354	LUAD_E01319	LUNG	c.2159C>T	p.A720V	COSMIC	NP	NP
355	Ly1	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
356	MEL-JWCI-WGS-25	SKIN	c.1937A>T	p.Y646F	COSMIC	NP	NP
357	Mx42	LARGE INTESTINE	c.1381_1382insTA	p.R461fs*3	COSMIC	NP	NP
358	OCI-LY1	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
359	OCI-Ly1	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
360	Pfeiffer	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2045C>G	p.A682G	COSMIC	NP	NP
361	SJTALL013	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2051G>A	p.R684H	COSMIC	NP	NP
362	SKI	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
363	SKM-1	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>G	p.Y646C	COSMIC	NP	NP
364	SU-DHL-4	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>C	p.Y646S	COSMIC	NP	NP
365	SU-DHL-6	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1936T>A	p.Y646N	COSMIC	NP	NP
366	TCGA-18-3409-01	LUNG	c.1698C>T	p.R566R	COSMIC	NP	NP
367	TCGA-21-1076-01	LUNG	c.1135G>C	p.E379Q	COSMIC	NP	NP
368	TCGA-33-6737-01	LUNG	c.1033G>A	p.A345T	COSMIC	NP	Benign
369	TCGA-37-3789-01	LUNG	c.1667C>G	p.S556*	COSMIC	NP	NP
370	TCGA-38-4631-01	LUNG	c.1880C>A	p.A627E	COSMIC	NP	NP
371	TCGA-39-5028-01	LUNG	c.1029C>G	p.L343L	COSMIC	NP	NP
372	TCGA-39-5031-01	LUNG	c.958C>T	p.L320L	COSMIC	NP	NP
373	TCGA-49-6743-01	LUNG	c.191G>T	p.R64M	COSMIC	PASSENGER/OTHER	Probably Damaging
374	TCGA-60-2725-01	LUNG	c.1657C>G	p.Q553E	COSMIC	NP	NP
375	TCGA-66-2782-01	LUNG	c.2136G>A	p.R712R	COSMIC	NP	NP
376	TCGA-67-3771-01	LUNG	c.1505G>A	p.R502Q	COSMIC	NP	NP
377	TCGA-78-7155-01	LUNG	c.101G>T	p.R34L	COSMIC	PASSENGER/OTHER	Possibly Damaging
378	TCGA-97-7554-01	LUNG	c.1036G>A	p.E346K	COSMIC	NP	NP
379	TCGA-A6-2676-01	LARGE INTESTINE	c.2002T>A	p.C668S	COSMIC	NP	NP
380	TCGA-A6-3809-01	LARGE INTESTINE	c.926A>G	p.N309S	COSMIC	NP	NP
381	TCGA-A6-5657-01	LARGE INTESTINE	c.621A>G	p.R207R	COSMIC	NP	NP
382	TCGA-A6-5660-01	LARGE INTESTINE	c.185A>G	p.Q62R	COSMIC	PASSENGER/OTHER	Benign
383	TCGA-A6-5661-01	LARGE INTESTINE	c.552T>C	p.D184D	COSMIC	NP	NP
384	TCGA-A6-5661-01	LARGE INTESTINE	c.727A>G	p.K243E	COSMIC	PASSENGER/OTHER	Possibly Damaging
385	TCGA-A6-5665-01	LARGE INTESTINE	c.185A>G	p.Q62R	COSMIC	PASSENGER/OTHER	Benign
386	TCGA-A6-5665-01	LARGE INTESTINE	c.575A>G	p.D192G	COSMIC	PASSENGER/OTHER	Benign
387	TCGA-A6-6141-01	LARGE INTESTINE	c.451A>C	p.K151Q	COSMIC	PASSENGER/OTHER	Benign
388	TCGA-A6-6653-01	LARGE INTESTINE	c.184C>T	p.Q62*	COSMIC	NP	NP
389	TCGA-A6-6781-01	LARGE INTESTINE	c.620G>T	p.R207L	COSMIC	PASSENGER/OTHER	Benign
390	TCGA-AA-3510-01	LARGE INTESTINE	c.1741G>A	p.A581T	COSMIC	NP	NP
391	TCGA-AA-3516-01	LARGE INTESTINE	c.1911G>A	p.V637V	COSMIC	NP	NP
392	TCGA-AA-3662-01	LARGE INTESTINE	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
393	TCGA-AA-3663-01	LARGE INTESTINE	c.2080C>T	p.H694Y	COSMIC	NP	NP
394	TCGA-AA-3672-01	LARGE INTESTINE	c.638G>A	p.R213H	COSMIC	PASSENGER/OTHER	Benign
395	TCGA-AA-3712-01	LARGE INTESTINE	c.2137A>G	p.I713V	COSMIC	NP	NP
396	TCGA-AA-3713-01	LARGE INTESTINE	c.1990G>T	p.D664Y	COSMIC	NP	NP
397	TCGA-AA-3713-01	LARGE INTESTINE	c.764C>T	p.A255V	COSMIC	PASSENGER/OTHER	Possibly Damaging
398	TCGA-AA-3864-01	LARGE INTESTINE	c.2058T>C	p.G686G	COSMIC	NP	NP
399	TCGA-AA-A00N-01	LARGE INTESTINE	c.2173G>A	p.E725K	COSMIC	NP	NP
400	TCGA-AA-A010-01	LARGE INTESTINE	c.507A>C	p.E169D	COSMIC	PASSENGER/OTHER	Benign
401	TCGA-AA-A01R-01	LARGE INTESTINE	c.1221T>C	p.D407D	COSMIC	NP	NP
402	TCGA-AB-2817-03	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2230_2231insTGCAT	p.I744fs*>10	COSMIC	NP	NP
403	TCGA-AB-2817-03	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2231_2232insTGCAT	p.E745fs*>9	COSMIC	NP	NP
404	TCGA-AB-2887-03	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2069G>A	p.R690H	COSMIC	NP	NP
405	TCGA-AD-6964-01	LARGE INTESTINE	c.1100G>A	p.S367N	COSMIC	NP	NP
406	TCGA-AF-6672-01	LARGE INTESTINE	c.620G>C	p.R207P	COSMIC	PASSENGER/OTHER	Benign
407	TCGA-AH-6544-01	LARGE INTESTINE	c.1034C>A	p.A345D	COSMIC	NP	NP
408	TCGA-AN-A0XW-01	BREAST	c.1931C>G	p.S644*	COSMIC	NP	NP
409	TCGA-AP-A051-01	ENDOMETRIUM	c.2004C>T	p.C668C	COSMIC	NP	NP
410	TCGA-AP-A056-01	ENDOMETRIUM	c.1505G>A	p.R502Q	COSMIC	NP	NP
411	TCGA-AP-A056-01	ENDOMETRIUM	c.1634A>C	p.Q545P	COSMIC	NP	NP
412	TCGA-AP-A059-01	ENDOMETRIUM	c.484G>T	p.E162*	COSMIC	NP	NP
413	TCGA-AP-A059-01	ENDOMETRIUM	c.697G>T	p.D233Y	COSMIC	PASSENGER/OTHER	Benign
414	TCGA-AP-A0LM-01	ENDOMETRIUM	c.2033T>G	p.F678C	COSMIC	NP	NP
415	TCGA-AP-A0LM-01	ENDOMETRIUM	c.233G>A	p.R78H	COSMIC	PASSENGER/OTHER	Possibly Damaging
416	TCGA-AX-A05Z-01	ENDOMETRIUM	c.2233G>A	p.E745K	COSMIC	NP	NP
417	TCGA-AY-6196-01	LARGE INTESTINE	c.185A>G	p.Q62R	COSMIC	PASSENGER/OTHER	Benign
418	TCGA-AY-6197-01	LARGE INTESTINE	c.1730C>T	p.P577L	COSMIC	NP	NP
419	TCGA-AZ-6599-01	LARGE INTESTINE	c.2193C>T	p.Y731Y	COSMIC	NP	NP
420	TCGA-AZ-6599-01	LARGE INTESTINE	c.745G>A	p.E249K	COSMIC	PASSENGER/OTHER	Possibly Damaging
421	TCGA-AZ-6599-01	LARGE INTESTINE	c.949G>A	p.E317K	COSMIC	NP	NP
422	TCGA-AZ-6608-01	LARGE INTESTINE	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
423	TCGA-B0-4706-01	KIDNEY	c.182A>G	p.K61R	COSMIC	PASSENGER/OTHER	Probably Damaging
424	TCGA-B5-A0JY-01	ENDOMETRIUM	c.736G>T	p.E246*	COSMIC	NP	NP
425	TCGA-B5-A11E-01	ENDOMETRIUM	c.1201G>T	p.E401*	COSMIC	NP	NP
426	TCGA-B5-A11E-01	ENDOMETRIUM	c.867T>C	p.C289C	COSMIC	NP	NP
427	TCGA-B5-A11G-01	ENDOMETRIUM	c.1060C>T	p.R354C	COSMIC	PASSENGER/OTHER	Possibly Damaging
428	TCGA-B8-5163-01	KIDNEY	c.17A>T	p.K6M	COSMIC	PASSENGER/OTHER	Probably Damaging
429	TCGA-BS-A0TC-01	ENDOMETRIUM	c.721A>C	p.K241Q	COSMIC	PASSENGER/OTHER	Probably Damaging
430	TCGA-BS-A0UV-01	ENDOMETRIUM	c.2085G>A	p.S695S	COSMIC	NP	NP
431	TCGA-CA-6717-01	LARGE INTESTINE	c.119G>T	p.S40I	COSMIC	PASSENGER/OTHER	Benign
432	TCGA-CA-6717-01	LARGE INTESTINE	c.745G>A	p.E249K	COSMIC	PASSENGER/OTHER	Possibly Damaging
433	TCGA-CA-6718-01	LARGE INTESTINE	c.2051G>A	p.R684H	COSMIC	NP	NP
434	TCGA-CK-5915-01	LARGE INTESTINE	c.1968T>C	p.A656A	COSMIC	NP	NP
435	TCGA-CM-5344-01	LARGE INTESTINE	c.863G>A	p.R288Q	COSMIC	PASSENGER/OTHER	Possibly Damaging
436	TCGA-CM-5348-01	LARGE INTESTINE	c.619C>A	p.R207R	COSMIC	NP	NP
437	TCGA-CM-5861-01	LARGE INTESTINE	c.804T>C	p.N268N	COSMIC	NP	NP
438	TCGA-CM-5863-01	LARGE INTESTINE	c.184C>A	p.Q62K	COSMIC	PASSENGER/OTHER	Benign
439	TCGA-CM-5864-01	LARGE INTESTINE	c.1872T>G	p.S624S	COSMIC	NP	NP
440	TCGA-CM-5864-01	LARGE INTESTINE	c.434T>C	p.F145S	COSMIC	PASSENGER/OTHER	Possibly Damaging
441	TCGA-CM-6171-01	LARGE INTESTINE	c.2079T>C	p.N693N	COSMIC	NP	NP
442	TCGA-CZ-5467-01	KIDNEY	c.1768T>A	p.C590S	COSMIC	NP	NP
443	TCGA-D1-A103-01	ENDOMETRIUM	c.2178G>T	p.E726D	COSMIC	NP	NP
444	TCGA-D1-A16Y-01	ENDOMETRIUM	c.2233G>A	p.E745K	COSMIC	NP	NP
445	TCGA-D1-A17Q-01	ENDOMETRIUM	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
446	TCGA-D5-5540-01	LARGE INTESTINE	c.727A>G	p.K243E	COSMIC	PASSENGER/OTHER	Possibly Damaging
447	TCGA-D5-5541-01	LARGE INTESTINE	c.2193C>T	p.Y731Y	COSMIC	NP	NP
448	TCGA-D5-6535-01	LARGE INTESTINE	c.2022G>A	p.L674L	COSMIC	NP	NP
449	TCGA-D5-6535-01	LARGE INTESTINE	c.731A>G	p.Y244C	COSMIC	PASSENGER/OTHER	Probably Damaging
450	TCGA-D5-6536-01	LARGE INTESTINE	c.2139A>G	p.I713M	COSMIC	NP	NP
451	TCGA-D5-6537-01	LARGE INTESTINE	c.1990G>A	p.D664N	COSMIC	NP	NP
452	TCGA-D5-6540-01	LARGE INTESTINE	c.1525A>T	p.R509*	COSMIC	NP	NP
453	TCGA-D5-6541-01	LARGE INTESTINE	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
454	TCGA-D5-6920-01	LARGE INTESTINE	c.730T>C	p.Y244H	COSMIC	PASSENGER/OTHER	Probably Damaging
455	TCGA-D5-6928-01	LARGE INTESTINE	c.75A>T	p.R25R	COSMIC	NP	NP
456	TCGA-DM-A1D6-01	LARGE INTESTINE	c.619C>A	p.R207R	COSMIC	NP	NP
457	TCGA-DM-A1DB-01	LARGE INTESTINE	c.619C>A	p.R207R	COSMIC	NP	NP
458	TCGA-DM-A1DB-01	LARGE INTESTINE	c.755T>C	p.L252P	COSMIC	PASSENGER/OTHER	Benign
459	TCGA-DM-A28F-01	LARGE INTESTINE	c.983A>G	p.Q328R	COSMIC	NP	NP
460	TCGA-DM-A28H-01	LARGE INTESTINE	c.2079T>C	p.N693N	COSMIC	NP	NP
461	TCGA-DM-A28K-01	LARGE INTESTINE	c.576T>C	p.D192D	COSMIC	NP	NP
462	TCGA-DM-A28K-01	LARGE INTESTINE	c.619C>A	p.R207R	COSMIC	NP	NP
463	TCGA-DY-A0XA-01	LARGE INTESTINE	c.864A>G	p.R288R	COSMIC	NP	NP
464	TCGA-EI-6507-01	LARGE INTESTINE	c.849G>A	p.T283T	COSMIC	NP	NP
465	TCGA-EW-A1IZ-01	BREAST	c.555C>T	p.D185D	COSMIC	NP	NP
466	TCGA-F4-6460-01	LARGE INTESTINE	c.747A>G	p.E249E	COSMIC	NP	NP
467	TCGA-F4-6808-01	LARGE INTESTINE	c.890A>G	p.H297R	COSMIC	PASSENGER/OTHER	Possibly Damaging
468	TCGA-G2-A3IB-01	URINARY TRACT	c.1689G>T	p.P563P	COSMIC	NP	NP
469	TCGA-G4-6303-01	LARGE INTESTINE	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
470	TCGA-G4-6306-01	LARGE INTESTINE	c.1990G>T	p.D664Y	COSMIC	NP	NP
471	TCGA-G4-6317-01	LARGE INTESTINE	c.983A>G	p.Q328R	COSMIC	NP	NP
472	TCGA-G4-6586-01	LARGE INTESTINE	c.620G>A	p.R207Q	COSMIC	PASSENGER/OTHER	Benign
473	TCGA-G4-6588-01	LARGE INTESTINE	c.1919A>G	p.N640S	COSMIC	NP	NP
474	TCGA-G4-6625-01	LARGE INTESTINE	c.951A>G	p.E317E	COSMIC	NP	NP
475	TCGA-G4-6626-01	LARGE INTESTINE	c.435C>T	p.F145F	COSMIC	NP	NP
476	TCGA-G4-6626-01	LARGE INTESTINE	c.475G>A	p.G159R	COSMIC	PASSENGER/OTHER	Probably Damaging
477	TCGA-G4-6628-01	LARGE INTESTINE	c.2137A>G	p.I713V	COSMIC	NP	NP
478	TCGA-H4-A2HQ-01	URINARY TRACT	c.434_435TC>AT	p.F145Y	COSMIC	PASSENGER/OTHER	Possibly Damaging
479	WSU-DLCL2	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1937A>T	p.Y646F	COSMIC	NP	NP
480	YUKIL	SKIN	c.1936T>A	p.Y646N	COSMIC	NP	NP
481	YULAPE	SKIN	c.1040G>A	p.R347Q	COSMIC	NP	NP
482	YUPAT	SKIN	c.1936T>A	p.Y646N	COSMIC	NP	NP
483	YUPAT	SKIN	c.686C>T	p.S229L	COSMIC	PASSENGER/OTHER	Possibly Damaging
484	cSCCP7	SKIN	c.1936T>A	p.Y646N	COSMIC	NP	NP
485	tAML-01	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1991A>C	p.D664A	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for EZH2!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test
Tertiary structure (+)

Users must enabled the Java in their browser to see structure.
Users can also download Java from here.

Modelled Structure Structures available in PDB

2C6V, 4MI0, 4MI5,

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PB008232	Pfam-B_8232	18	157	2.1e-25
PF11616	EZH2_WD-Binding	39	68	6.8e-19
PB017256	Pfam-B_17256	107	181	8.1e-51
PB011744	Pfam-B_11744	111	176	3.3e-05
PB017256	Pfam-B_17256	258	694	1.3e-25
PB002306	Pfam-B_2306	273	334	0.0006
PB007590	Pfam-B_7590	505	589	4.1e-08
PF00856	SET	623	726	1.3e-22

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0048183	515	736	8.39e-62
0050913	431	469	1.54e-03

Sequence Alignment (+)

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Users can also download Java from here.

1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo"

"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"

S. No. Position Amino acid Type

"; } else{echo"
Post translational modifications are not found!!

";} ?>

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
EZH2	EZH2	EZH2	ENSP00000320147	Q15910
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q15910	EZH2	ENSP00000320147	EZH2	Q15910
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
EZH2	ENSP00000320147	601573	Q15910	PA27939

Modelled Structure	Structures available in PDB
	2C6V, 4MI0, 4MI5,

dbEM

Protein: EZH2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)